scholarly journals Slow-dividing satellite cells retain long-term self-renewal ability in adult muscle

2012 ◽  
Vol 125 (5) ◽  
pp. 1309-1317 ◽  
Author(s):  
Y. Ono ◽  
S. Masuda ◽  
H.-s. Nam ◽  
R. Benezra ◽  
Y. Miyagoe-Suzuki ◽  
...  
Keyword(s):  
Satellite Cells ◽  
Self Renewal ◽  
Adult Muscle

Slow-dividing satellite cells retain long-term self-renewal ability in adult muscle

Development ◽  
2012 ◽  
Vol 139 (7) ◽  
pp. e707-e707
Author(s):  
Y. Ono ◽  
S. Masuda ◽  
H.-s. Nam ◽  
R. Benezra ◽  
Y. Miyagoe-Suzuki ◽  
...  
Keyword(s):  
Satellite Cells ◽  
Self Renewal ◽  
Adult Muscle

scholarly journals Myf5-Positive Satellite Cells Contribute to Pax7-Dependent Long-Term Maintenance of Adult Muscle Stem Cells

2013 ◽  
Vol 13 (6) ◽  
pp. 769
Author(s):  
Stefan Günther ◽  
Johnny Kim ◽  
Sawa Kostin ◽  
Christoph Lepper ◽  
Chen-Ming Fan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Satellite Cells ◽  
Muscle Stem Cells ◽  
Adult Muscle ◽  
Term Maintenance

scholarly journals Myf5-Positive Satellite Cells Contribute to Pax7-Dependent Long-Term Maintenance of Adult Muscle Stem Cells

2013 ◽  
Vol 13 (5) ◽  
pp. 590-601 ◽  
Author(s):  
Stefan Günther ◽  
Johnny Kim ◽  
Sawa Kostin ◽  
Christoph Lepper ◽  
Chen-Ming Fan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Satellite Cells ◽  
Muscle Stem Cells ◽  
Adult Muscle ◽  
Term Maintenance

PAX3+skeletal muscle satellite cells retain long-term self-renewal and proliferation

2016 ◽  
Vol 54 (5) ◽  
pp. 943-951 ◽  
Author(s):  
Qiumei Yang ◽  
Jie Yu ◽  
Bing Yu ◽  
Zhiqing Huang ◽  
Keying Zhang ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Satellite Cells ◽  
Self Renewal ◽  
Muscle Satellite Cells ◽  
Skeletal Muscle Satellite Cells

scholarly journals STAT3 Regulates Self-Renewal of Adult Muscle Satellite Cells during Injury-Induced Muscle Regeneration

Cell Reports ◽  
2016 ◽  
Vol 16 (8) ◽  
pp. 2102-2115 ◽  
Author(s):  
Han Zhu ◽  
Fang Xiao ◽  
Gang Wang ◽  
Xiuqing Wei ◽  
Lei Jiang ◽  
...  
Keyword(s):  
Satellite Cells ◽  
Muscle Regeneration ◽  
Self Renewal ◽  
Muscle Satellite Cells ◽  
Adult Muscle

scholarly journals Lentivector-Mediated Transfer of Bmi-1 and Telomerase in Muscle Satellite Cells Yields a Duchenne Myoblast Cell Line with Long-Term Genotypic and Phenotypic Stability

2003 ◽  
Vol 14 (16) ◽  
pp. 1525-1533 ◽  
Author(s):  
Christophe Cudré-Mauroux ◽  
Teresa Occhiodoro ◽  
Stéphane König ◽  
Patrick Salmon ◽  
Laurent Bernheim ◽  
...  
Keyword(s):  
Cell Line ◽  
Satellite Cells ◽  
Phenotypic Stability ◽  
Muscle Satellite Cells ◽  
Myoblast Cell Line ◽  
Myoblast Cell

193 Single Cell RNA-sequencing Reveals a Role of Lipid Metabolism in Muscle Satellite Cells

2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 104-105
Author(s):  
Shihuan Kuang ◽  
Feng Yue ◽  
Stephanie Oprescu
Keyword(s):  
Gene Expression ◽  
Lipid Metabolism ◽  
Cell Fate ◽  
Satellite Cell ◽  
Satellite Cells ◽  
Lipid Droplets ◽  
Self Renewal ◽  
Droplet Dynamics ◽  
Single Cell Rna Sequencing

Abstract Single Cell RNA-sequencing (scRNA-seq) is a powerful technique to deconvolute gene expression of various subset of cells intermingled within a complex tissue, such as the skeletal muscle. We first used scRNA-seq to understand dynamics of cell populations and their gene expression during muscle regeneration in murine limb muscles. This leads to the identification of a subset of satellite cells (the resident stem cells of skeletal muscles) with immune gene signatures in regenerating muscles. Next, we used scRNA-seq to examine gene expression dynamics of satellite cells at various status: quiescence, activation, proliferation, differentiation and self-renewal. This analysis uncovers stage-dependent changes in expression of genes related to lipid metabolism. Further analyses lead to the discovery of previously unappreciated dynamics of lipid droplets in satellite cells; and demonstrate that the abundance of the lipid droplets in newly divided satellite daughter cells is linked to cell fate segregation into differentiation versus self-renewal. Perturbation of lipid droplet dynamics through blocking lipolysis disrupts cell fate homeostasis and impairs muscle regeneration. Finally, we show that lipid metabolism regulates the function of satellite cells through two mechanisms. On one hand, lipid metabolism functions as an energy source through fatty acid oxidation (FAO), and blockage of FAO reduces energy production that is critical for satellite cell function. On the other hand, lipid metabolism generates bioactive molecules that influence signaling transduction and gene expression. In this scenario, lipid metabolism and FAO regulate the intracellular levels of acetyl-coA and selective acetylation of PAX7, a pivotal transcriptional factor underlying function of satellite cells. These results together reveal for the first time a critical role of lipid metabolism and lipid droplet dynamics in muscle satellite cell fate determination and regenerative function; and underscore a potential role of dietary fatty acids in satellite cell-dependent muscle development, growth and regeneration.

Optimization of Culture Conditions to Support Long-Term Self-Renewal of Buffalo (Bubalus bubalis) Embryonic Stem Cell-Like Cells

2011 ◽  
Vol 13 (6) ◽  
pp. 539-549 ◽  
Author(s):  
Ruchi Sharma ◽  
Aman George ◽  
Nitin Manchindra Kamble ◽  
Karn Pratap Singh ◽  
Manmohan Singh Chauhan ◽  
...  
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Bubalus Bubalis ◽  
Culture Conditions ◽  
Self Renewal ◽  
Optimization Of Culture Conditions
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