- Biosensors for the Assessment of Natural Toxins in Food

Natural Toxins and Drug Discovery

Chinese Journal of Natural Medicines ◽

10.3724/sp.j.1009.2009.00162 ◽

2009 ◽

Vol 7 (3) ◽

pp. 162-168

Author(s):

Ji-Sheng CHEN

Keyword(s):

Drug Discovery ◽

Natural Toxins

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Natural Macromolecules with Protective and Antitumor Activity

Anti-Cancer Agents in Medicinal Chemistry ◽

10.2174/1871520618666180425115029 ◽

2018 ◽

Vol 18 (5) ◽

pp. 675-683 ◽

Cited By ~ 2

Author(s):

Cioanca Oana ◽

Trifan Adriana ◽

Cornelia Mircea ◽

Scripcariu Dragos ◽

Hancianu Monica

Keyword(s):

Immune Response ◽

Antitumor Activity ◽

Tumor Cells ◽

Biological Activities ◽

Molecular Size ◽

Plant Lectins ◽

Natural Toxins ◽

Glycosidic Bonds ◽

Novel Drug

This review summarizes the literature data regarding plant lectins as novel drug sources in the prevention or treatment of cancer. Moreover, such compounds have been described as natural toxins that possess different biological activities (cytotoxic, antitumor, antimutagenic and anticarcinogenic properties). This activity depends greatly on their structure and affinity. Most of the mushroom heterosides are known as β-glucans with β-(1→3)-glycosidic bonds. It is thought that their conformation, bonds, molecular size can modulate the immune response by triggering different receptors. The mechanism on normal and tumor cells of various plant and mushroom polysaccharides and lectins is briefly presented in this paper.

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Drug Development Using Natural Toxins

Toxins ◽

10.3390/toxins13060414 ◽

2021 ◽

Vol 13 (6) ◽

pp. 414

Author(s):

Gihyun Lee

Keyword(s):

Drug Development ◽

Natural Toxins

Natural toxins are poisonous substances produced by bacteria, insects, animals, or plants [...]

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Natural and Designed Toxins for Precise Therapy: Modern Approaches in Experimental Oncology

International Journal of Molecular Sciences ◽

10.3390/ijms22094975 ◽

2021 ◽

Vol 22 (9) ◽

pp. 4975

Author(s):

Olga Shilova ◽

Elena Shramova ◽

Galina Proshkina ◽

Sergey Deyev

Keyword(s):

Cancer Cells ◽

Targeted Delivery ◽

Combined Therapy ◽

Drug Carriers ◽

Cytotoxic Action ◽

Growth And Survival ◽

Surface Receptors ◽

Nanosized Materials ◽

Natural Toxins ◽

Protein Toxins

Cancer cells frequently overexpress specific surface receptors providing tumor growth and survival which can be used for precise therapy. Targeting cancer cell receptors with protein toxins is an attractive approach widely used in contemporary experimental oncology and preclinical studies. Methods of targeted delivery of toxins to cancer cells, different drug carriers based on nanosized materials (liposomes, nanoparticles, polymers), the most promising designed light-activated toxins, as well as mechanisms of the cytotoxic action of the main natural toxins used in modern experimental oncology, are discussed in this review. The prospects of the combined therapy of tumors based on multimodal nanostructures are also discussed.

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