scholarly journals Anxiety as a risk factor of Alzheimer's disease and vascular dementia – ERRATUM

2018 ◽  
Vol 214 (3) ◽  
pp. 174-174
Author(s):  
Eva Becker ◽  
Claudia Lorena Orellana Rios ◽  
Claas Lahmann ◽  
Gerta Rücker ◽  
Joachim Bauer ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Vascular Dementia

scholarly journals Anxiety as a risk factor of Alzheimer's disease and vascular dementia

2018 ◽  
Vol 213 (5) ◽  
pp. 654-660 ◽  
Author(s):  
Eva Becker ◽  
Claudia Lorena Orellana Rios ◽  
Claas Lahmann ◽  
Gerta Rücker ◽  
Joachim Bauer ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Vascular Dementia ◽  
Functional Relation ◽  
Hazard Ratio ◽  
Brain Health ◽  
Future Studies ◽  
Prognostic Effect

BackgroundThe aetiology of dementia is not yet fully understood. Stress can have a damaging effect on brain health. The prognostic effect of anxiety is still unclear regarding Alzheimer's disease as well as vascular dementia.AimsTo explore the association between anxiety and future dementia.MethodMedline, PsycINFO, CINAHL, Web of Science and ALOIS were searched for publications up to 12 January 2018. Longitudinal studies with a follow-up of at least 2 years were included, if the trait or state anxiety had been assessed at baseline. Studies with cognitive impairment at baseline were not included. We used a random effects model to calculate the pooled time to Alzheimer's disease and incidence of vascular dementia.ResultsAnxiety predicts risk of Alzheimer's disease (n = 26 193 out of seven studies, hazard ratio1.53, 95% CI 1.16–2.01, P < 0.01) and vascular dementia (n = 4916 out of two studies, odds ratio1.88, 95% CI 1.05–3.36, P < 0.01). The pooled hazard ratio regarding risk of Alzheimer's disease was still significant when excluding studies with critical risk of bias (n = 14 110 out of six studies, hazard ratio 1.35, 95% CI 1.08–1.70, P < 0.01).ConclusionsAnxiety is a risk factor for both types of dementia. The temporal and functional relation between anxiety and dementia needs investigation in future studies. The protective value of treating anxiety should be explored further.Declaration of interestNone.

Diabetes Mellitus Is a Risk Factor for Vascular Dementia, but Not for Alzheimer's Disease: A Population-Based Study of the Oldest Old

2002 ◽  
Vol 14 (3) ◽  
pp. 239-248 ◽  
Author(s):  
Linda B. Hassing ◽  
Boo Johansson ◽  
Sven E. Nilsson ◽  
Stig Berg ◽  
Nancy L. Pedersen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Alzheimer’S Disease ◽  
Type 2 Diabetes ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Vascular Dementia ◽  
Population Based ◽  
Diabetes Diagnosis ◽  
Increased Risk

Background: The purpose of this study was to examine if Type 2 diabetes mellitus is a risk factor for dementia in very old age, specifically for Alzheimer's disease (AD) and vascular dementia (VaD). Methods: We evaluated the risk of dementia in relation to Type 2 diabetes using a population-based sample of 702 individuals aged 80 years and older (mean age 83 years). A total of 187 persons received a dementia diagnosis. Thirty-one individuals had a diabetes diagnosis prior to onset of the dementia. Results: Cox proportional hazard analyses, adjusted for age, gender, education, smoking habits, and circulatory diseases, indicated an elevated risk to develop VaD (relative risk = 2.54, 95% confidence interval 1.35–4.78) in individuals with diabetes mellitus. No association was found between diabetes and AD. Conclusion: Type 2 diabetes is selectively related to the different subtypes of dementia. There is no increased risk of AD but more than a twofold risk of VaD in persons with diabetes.

scholarly journals Uric Acid and Cognitive Function in Older Individuals

Nutrients ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 975 ◽  
Author(s):  
Claudio Tana ◽  
Andrea Ticinesi ◽  
Beatrice Prati ◽  
Antonio Nouvenne ◽  
Tiziana Meschi
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Uric Acid ◽  
Risk Factor ◽  
Cognitive Function ◽  
Vascular Dementia ◽  
Serum Uric Acid ◽  
Prognostic Significance ◽  
Antioxidant Properties ◽  
Older Individuals

Hyperuricemia has been recognized as an independent cardiovascular risk factor in epidemiological studies. However, uric acid can also exert beneficial functions due to its antioxidant properties, which may be particularly relevant in the context of neurodegenerative diseases. In this paper, we critically revise the evidence on the relationship between serum uric acid levels and cognitive function in older individuals, focusing on the etiology of cognitive impairment (Alzheimer’s disease, Parkinson’s dementia, and vascular dementia) and on the interactive connections between uric acid, dementia, and diet. Despite high heterogeneity in the existing studies, due to different characteristics of studied populations and methods of cognitive dysfunction assessment, we conclude that serum uric acid may modulate cognitive function in a different way according to the etiology of dementia. Current studies indeed demonstrate that uric acid may exert neuroprotective actions in Alzheimer’s disease and Parkinson’s dementia, with hypouricemia representing a risk factor for a quicker disease progression and a possible marker of malnutrition. Conversely, high serum uric acid may negatively influence the disease course in vascular dementia. Further studies are needed to clarify the physio-pathological role of uric acid in different dementia types, and its clinical-prognostic significance.

P4-340: Is apolipoprotein E epsilon4 allele a higher risk factor for Alzheimer's disease than for vascular dementia? A neuropathological study

2011 ◽  
Vol 7 ◽  
pp. e31-e31
Author(s):  
Claudia Suemoto ◽  
Lea Grinberg ◽  
David Schlesinger ◽  
Jose Farfel ◽  
Renata Leite ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Apolipoprotein E ◽  
Vascular Dementia

scholarly journals Prevalence of dementia in an urban population in Kerala, India

2005 ◽  
Vol 186 (2) ◽  
pp. 136-140 ◽  
Author(s):  
S. Shaji ◽  
Srija Bose ◽  
Abraham Verghese
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Vascular Dementia ◽  
Health Problem ◽  
Urban Population ◽  
Important Health ◽  
History Of ◽  
Prevalence Of Dementia

BackgroundDementia is emerging as an important health problem of elderly people in India.AimsTo investigate the prevalence, psychosocial correlates and risk factors of various dementing disorders in an urban population in Kerala, southern India.MethodA door-to-door survey was conducted in the city of Kochi (Cochin) to identify residents aged ?65 years using cluster sampling. Of 1934 people screened with a vernacular adaptation of the Mini-Mental State Examination, all those scoring at or below the cut-off of 23 were evaluated further and those with confirmed cognitive and functional impairment were assigned diagnoses according to DSM–IV criteria. Identified cases were categorised by ICD–10 criteria. Ten percent of those screened as negative were evaluated at each stage.ResultsPrevalence of dementia was 33. 6 per 1000 (95% Cl 27.3–40.7). Alzheimer's disease was the most common type (54%) followed by vascular dementia (39%), and 7% of cases were due to causes such as infection, tumour and trauma. Family history of dementia was a risk factor for Alzheimer's disease and history of hypertension was a risk factor for vascular dementia.ConclusionsDementia is an important health problem of the elderly population. Identification of risk factors points towards the possibility of prevention.

ACE I/D polymorphism is a risk factor of Alzheimer's disease but not of vascular dementia

2005 ◽  
Vol 377 (1) ◽  
pp. 37-39 ◽  
Author(s):  
H. Kölsch ◽  
F. Jessen ◽  
N. Freymann ◽  
M. Kreis ◽  
F. Hentschel ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Vascular Dementia
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