Apolipoprotein E ?4 allele is a risk factor for late-onset Alzheimer's disease and vascular dementia in Han Chinese

2001 ◽  
Vol 16 (4) ◽  
pp. 438-439 ◽  
Author(s):  
J. G. Zhang ◽  
J. G. Yang ◽  
Z. X. Lin ◽  
L. He ◽  
G. Y. Feng ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Apolipoprotein E ◽  
Vascular Dementia ◽  
Late Onset ◽  
Han Chinese

Confirmation of the  4 allele of the apolipoprotein E gene as a risk factor for late-onset Alzheimer's disease

Neurology ◽  
1994 ◽  
Vol 44 (2) ◽  
pp. 342-342 ◽  
Author(s):  
T. Brousseau ◽  
S. Legrain ◽  
C. Berr ◽  
V. Gourlet ◽  
O. Vidal ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Apolipoprotein E ◽  
Late Onset ◽  
E Gene ◽  
Apolipoprotein E Gene

Apolipoprotein E ε4/4 genotype limits response to dietary induction of hyperhomocysteinemia and resulting inflammatory signaling

2022 ◽  
pp. 0271678X2110690
Author(s):  
Charles E Seaks ◽  
Erica M Weekman ◽  
Tiffany L Sudduth ◽  
Kevin Xie ◽  
Brandi Wasek ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Apolipoprotein E ◽  
Late Onset ◽  
Apoe Ε4 ◽  
Perivascular Inflammation ◽  
Ε4 Allele ◽  
Barrier Breakdown ◽  
The Impact

Vascular contributions to cognitive impairment and dementia (VCID) are the second leading cause of dementia behind Alzheimer’s disease. Apolipoprotein E (ApoE) is a lipid transporting lipoprotein found within the brain and periphery. The APOE ε4 allele is the strongest genetic risk factor for late onset Alzheimer’s disease and is a risk factor for VCID. Our lab has previously utilized a dietary model of hyperhomocysteinemia (HHcy) to induce VCID pathology and cognitive deficits in mice. This diet induces perivascular inflammation through cumulative oxidative damage leading to glial mediated inflammation and blood brain barrier breakdown. Here, we examine the impact of ApoE ε4 compared to ε3 alleles on the progression of VCID pathology and inflammation in our dietary model of HHcy. We report a significant resistance to HHcy induction in ε4 mice, accompanied by a number of related differences related to homocysteine (Hcy) metabolism and methylation cycle, or 1-C, metabolites. There were also significant differences in inflammatory profiles between ε3 and ε4 mice, as well as significant reduction in Serpina3n, a serine protease inhibitor associated with ApoE ε4, expression in ε4 HHcy mice relative to ε4 controls. Finally, we find evidence of pervasive sex differences within both genotypes in response to HHcy induction.

Apolipoprotein E, ɛ4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region

1994 ◽  
Vol 3 (4) ◽  
pp. 569-574 ◽  
Author(s):  
Marie-Christine Chartier-Hariln ◽  
Matthew Parfitt ◽  
Sylvle Legrain ◽  
Jordi Pérez-Tur ◽  
Thierry Brousseau ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Apolipoprotein E ◽  
Chromosomal Region ◽  
Late Onset ◽  
Major Risk Factor ◽  
E4 Allele ◽  
Disease Analysis

P4-340: Is apolipoprotein E epsilon4 allele a higher risk factor for Alzheimer's disease than for vascular dementia? A neuropathological study

2011 ◽  
Vol 7 ◽  
pp. e31-e31
Author(s):  
Claudia Suemoto ◽  
Lea Grinberg ◽  
David Schlesinger ◽  
Jose Farfel ◽  
Renata Leite ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Apolipoprotein E ◽  
Vascular Dementia

Association of TOMM40 Polymorphisms with Late-Onset Alzheimer’s Disease in a Northern Han Chinese Population

2013 ◽  
Vol 15 (2) ◽  
pp. 279-287 ◽  
Author(s):  
Xiao-Ying Ma ◽  
Jin-Tai Yu ◽  
Wei Wang ◽  
Hui-Fu Wang ◽  
Qiu-Yan Liu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Chinese Population ◽  
Late Onset ◽  
Han Chinese ◽  
Han Chinese Population

scholarly journals Emerging evidence for associations between periodontitis and the development of Alzheimer’s disease

2014 ◽  
Vol 5 (1) ◽  
pp. 38-42 ◽  
Author(s):  
Sophie Poole ◽  
Sim K Singhrao ◽  
St John Crean
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Immune Responses ◽  
Periodontal Disease ◽  
Potential Risk ◽  
Inflammatory Disease ◽  
Pathogenic Bacteria ◽  
Late Onset ◽  
Systemic Circulation

Periodontal disease (PD) is an inflammatory disease affecting tooth-supporting tissues in which interaction of specific bacteria and the host’s immune responses play a pivotal role. The pathogenic bacteria associated with PD are a source of systemic inflammation as they have the ability to enter systemic circulation during everyday tasks such as brushing teeth and chewing food. Alzheimer’s disease (AD) is a form of dementia whereby inflammation is thought to play a key role in its pathogenesis and the risk of developing the disease increasing with age. The exact aetiology of the late-onset AD is unknown but peripheral infections are being considered as a potential risk factor.

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