Orofacial Dyskinesia in Down's Syndrome

1990 ◽  
Vol 157 (1) ◽  
pp. 131-132 ◽  
Author(s):  
Timothy G. Dinan ◽  
Theresa Golden
Keyword(s):  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Strong Relationship ◽  
Orofacial Dyskinesia ◽  
Neuroleptic Medication ◽  
Mental Handicap ◽  
Abnormal Movements

Of 54 patients aged 30–60 years with a diagnosis of Down's syndrome, 38 had evidence of orofacial dyskinesia, assessed using the AIMS. There was a strong relationship between the presence of such movements and the severity of mental handicap. No relationship was found between abnormal movements and age. None of the patients had previously taken neuroleptic medication.

Differential Rates of Psychiatric Disorders in Adults with Down's Syndrome Compared with Other Mentally Handicapped Adults

1992 ◽  
Vol 161 (5) ◽  
pp. 671-674 ◽  
Author(s):  
Richard A. Collacott ◽  
Sally-Ann Cooper ◽  
Catherine McGrother
Keyword(s):  
Personality Disorder ◽  
Mental Disorders ◽  
Conduct Disorder ◽  
Psychiatric Disorders ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Mentally Handicapped ◽  
Mental Handicap

The total number of adults with Down's syndrome living in Leicestershire, ascertained by widespread enquiry, was found to be 378. Of these, 371 were matched with adults with mental handicap due to other pathologies, on the basis of age, sex, and type of residence. Those with Down's syndrome were found to have a different spectrum of mental disorders from those without the syndrome. In particular, Down's syndrome patients were more likely to have been diagnosed as having depression and dementia; the controls were more likely to have been diagnosed as suffering from conduct disorder, personality disorder, or schizophrenia/paranoid state. The same proportion of each group had been given a diagnosis of autism.

Movement Disorder in Down's syndrome: A possible marker of the severity of mental handicap

1996 ◽  
Vol 11 (4) ◽  
pp. 395-403 ◽  
Author(s):  
Camilla M. Haw ◽  
Thomas R. E. Barnes ◽  
Kate Clark ◽  
Paul Crichton ◽  
Dora Kohen
Keyword(s):  
Movement Disorder ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Mental Handicap

Handedness in Mental Handicap: Investigation into Populations of Down's Syndrome, Epilepsy and Autism

1993 ◽  
Vol 163 (5) ◽  
pp. 674-676 ◽  
Author(s):  
J. Lewin ◽  
D. Kohen ◽  
G. Mathew
Keyword(s):  
Learning Disabilities ◽  
General Population ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Mental Handicap ◽  
Left Handedness ◽  
Medical Disorders ◽  
Significant Difference ◽  
Validated Instrument

The handedness in three randomly sampled groups of people with learning disabilities consisting of patients with Down's syndrome, epilepsy, and autism were studied using a validated instrument. All subjects were controlled for neurological and other medical disorders. A statistically significant increase in left-handedness and ambiguous handedness compared with the general population was found in all groups. There was no significant difference in the rate of left-handedness between the three groups.

Prevalence of the Fragile X Syndrome in an Institution for the Mentally Handicapped

1986 ◽  
Vol 148 (6) ◽  
pp. 655-657 ◽  
Author(s):  
David A. Primrose ◽  
Rabia El-Matmati ◽  
Elizabeth Boyd ◽  
Christine Gosden ◽  
Marjorie Newton
Keyword(s):  
Fragile X Syndrome ◽  
Fragile X ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Mentally Handicapped ◽  
Mental Handicap ◽  
Female Patients ◽  
X Cells

In an investigation to find the prevalence of the fragile X (Martin Bell) syndrome in a mental handicap hospital, chromosomal investigations were carried out in 196 males selected out of a total of 512, and also in 20 female patients who were related to some of the selected males. Fragile X cells were found in 41 of the males and two of the females; in 21 of the males it was associated with macro-orchidism. The overall prevalence in the hospital for males (8.0%) ranks this syndrome next in importance to Down's syndrome as a known cause for mental handicap.

The Motor Disorders of Mental Handicap

1991 ◽  
Vol 158 (1) ◽  
pp. 97-102 ◽  
Author(s):  
D. Rogers ◽  
C. Karki ◽  
C. Bartlett ◽  
P. Pocock
Keyword(s):  
Psychiatric Disorder ◽  
Significant Relationship ◽  
Psychiatric Illness ◽  
De Novo ◽  
Motor Disorder ◽  
Motor Disorders ◽  
Check List ◽  
Neuroleptic Medication ◽  
Mental Handicap ◽  
Abnormal Movements

Among 236 in-patients in one hospital for the mentally handicapped, there was a significant relationship between the amount of motor disorder (rated using a comprehensive check-list) and the severity of mental handicap, the presence of associated psychiatric disorder and the use of neuroleptic medication. The population was fairly evenly divided between those currently, previously and never having received neuroleptic medication. All categories of motor disorder, including abnormal movements, were present in all three subgroups. Neuroleptic medication appeared to modify the expression of motor disorder rather than producing it de novo. The range and frequency of motor disorders was comparable with that in patients with severe psychiatric illness. A common cerebral basis for the motor disorders of patients with mental handicap and severe psychiatric illness is suggested.

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