Prevalence of the Fragile X Syndrome in an Institution for the Mentally Handicapped

1986 ◽  
Vol 148 (6) ◽  
pp. 655-657 ◽  
Author(s):  
David A. Primrose ◽  
Rabia El-Matmati ◽  
Elizabeth Boyd ◽  
Christine Gosden ◽  
Marjorie Newton
Keyword(s):  
Fragile X Syndrome ◽  
Fragile X ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Mentally Handicapped ◽  
Mental Handicap ◽  
Female Patients ◽  
X Cells

In an investigation to find the prevalence of the fragile X (Martin Bell) syndrome in a mental handicap hospital, chromosomal investigations were carried out in 196 males selected out of a total of 512, and also in 20 female patients who were related to some of the selected males. Fragile X cells were found in 41 of the males and two of the females; in 21 of the males it was associated with macro-orchidism. The overall prevalence in the hospital for males (8.0%) ranks this syndrome next in importance to Down's syndrome as a known cause for mental handicap.

Down's syndrome and fragile-X syndrome in a single patient

2008 ◽  
Vol 34 (1) ◽  
pp. 81-86
Author(s):  
R. A. COLLACOTT ◽  
D. P. DUCKETT ◽  
D. MATHEWS ◽  
J. S. WARRINGTON ◽  
I. D. YOUNG
Keyword(s):  
Fragile X Syndrome ◽  
Fragile X ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Single Patient

Differential Rates of Psychiatric Disorders in Adults with Down's Syndrome Compared with Other Mentally Handicapped Adults

1992 ◽  
Vol 161 (5) ◽  
pp. 671-674 ◽  
Author(s):  
Richard A. Collacott ◽  
Sally-Ann Cooper ◽  
Catherine McGrother
Keyword(s):  
Personality Disorder ◽  
Mental Disorders ◽  
Conduct Disorder ◽  
Psychiatric Disorders ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Mentally Handicapped ◽  
Mental Handicap

The total number of adults with Down's syndrome living in Leicestershire, ascertained by widespread enquiry, was found to be 378. Of these, 371 were matched with adults with mental handicap due to other pathologies, on the basis of age, sex, and type of residence. Those with Down's syndrome were found to have a different spectrum of mental disorders from those without the syndrome. In particular, Down's syndrome patients were more likely to have been diagnosed as having depression and dementia; the controls were more likely to have been diagnosed as suffering from conduct disorder, personality disorder, or schizophrenia/paranoid state. The same proportion of each group had been given a diagnosis of autism.

Changing Sociological and Clinical Patterns in Mental Handicap

1984 ◽  
Vol 144 (1) ◽  
pp. 1-8
Author(s):  
D. A. Primrose
Keyword(s):  
Fragile X Syndrome ◽  
Historical Development ◽  
Birth Rate ◽  
Local Authority ◽  
Fragile X ◽  
Specialist Care ◽  
Mentally Handicapped ◽  
Mental Handicap ◽  
Adults And Children ◽  
And Training

SummaryThe historical development of official provision for the care and training of the mentally handicapped—both adults and children—is outlined, to show the changes between Local Authority and Government. Changes in emphasis between compulsory and voluntary admissions to institutions are discussed with particular reference to changes in the law and the administration of the services. Demographic changes due to longer survival, falling birth rate, and prevention, diagnosis and treatment of individual causes of mental handicap are discussed. Particular reference is made to Down's syndrome and to the fragile X syndrome.The need for psychiatrists in mental handicap is mentioned along with the benefit of early intervention. The numbers of the mentally handicapped needing specialist care and training are not diminishing, but the manner of provision is changing, and partly reverting to ways tried long ago.

Movement Disorder in Down's syndrome: A possible marker of the severity of mental handicap

1996 ◽  
Vol 11 (4) ◽  
pp. 395-403 ◽  
Author(s):  
Camilla M. Haw ◽  
Thomas R. E. Barnes ◽  
Kate Clark ◽  
Paul Crichton ◽  
Dora Kohen
Keyword(s):  
Movement Disorder ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Mental Handicap
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