Lithium Toxicity and Mefenamic Acid

1987 ◽  
Vol 151 (6) ◽  
pp. 847-848 ◽  
Author(s):  
R. K. Shelley
Keyword(s):  
Elderly Patient ◽  
Cardiac Failure ◽  
Mefenamic Acid ◽  
Lithium Carbonate ◽  
Lithium Toxicity ◽  
Vulnerability Factors ◽  
Glomerular Function ◽  
Manic Depressive Psychosis ◽  
Manic Depressive ◽  
History Of

An elderly patient with bipolar manic-depressive psychosis, stabilised satisfactorily on lithium carbonate, developed acute symptoms of lithium toxicity shortly after commencing mefenamic acid. Vulnerability factors for the interaction may have included age, history of cardiac failure, and impaired glomerular function. It is hypothesised that the interaction may have been mediated by inhibition of prostaglandin activity.

Ernst Kretschmer

2018 ◽  
pp. 133-140
Author(s):  
Mario Rossi Monti
Keyword(s):  
History Of Psychiatry ◽  
Manic Depressive Psychosis ◽  
Manic Depressive ◽  
Constitutional Type ◽  
Ernst Kretschmer ◽  
History Of ◽  
Point Of Reference

Ernst Kretschmer was an assistant to Professor Robert Gaupp in Tübingen. His contributions to the field of psychopathology can be reduced to two main themes: the first consists in the analysis of a particular form of delusion called “sensitive delusion of reference,” developed in his book Der Sensitive Beziehungswahn (The Sensitive Delusion of Reference) in 1918; the second concerns the construction of a constitutional typology which attempts to identify, on the basis of the temperamental and physical-constitutional characteristics of the subjects, all possible degrees and steps leading to the two major psychoses: manic-depressive psychosis and schizophrenia. While the somatic-based constitutional type now belongs to the history of psychiatry, the attention to the comprehensibility of the paths leading to the area of major psychoses remains an unavoidable point of reference for those who refuse to give up the attempt to introduce the dimension of subjectivity and understanding into the area of psychosis.

Mixed Affective States and the Natural History of Manic-Depressive Psychosis

1979 ◽  
Vol 134 (2) ◽  
pp. 153-160 ◽  
Author(s):  
C. M. H. Nunn
Keyword(s):  
Natural History ◽  
Random Sample ◽  
Alternative Model ◽  
Depressive Illness ◽  
Affective States ◽  
Manic Depressive Illness ◽  
Affective Psychosis ◽  
Manic Depressive Psychosis ◽  
Manic Depressive ◽  
History Of

SummarySince neither the unipolar nor the bipolar theories of manic-depressive psychosis explain all its features, an alternative model was tested. The hypotheses are that mixed affective psychoses represent a superimposition on hypomania of a second type of depression which can sometimes develop from the depressive phase of manic-depressive psychosis, and that schizophrenia occurring in the course of a manic-depressive illness is an alternative to mixed affective psychosis.From an examination of the clinical histories of a random sample of people with bipolar manic-depressive psychosis, evidence was found to support both ideas.

The First Lithium Clinic in Hong Kong: A Chinese Profile

1992 ◽  
Vol 26 (3) ◽  
pp. 450-453 ◽  
Author(s):  
Sing Lee
Keyword(s):  
Hong Kong ◽  
Serum Level ◽  
Unipolar Depression ◽  
Chinese Patients ◽  
Laboratory Monitoring ◽  
Manic Depressive Psychosis ◽  
Manic Depressive ◽  
High Prevalence ◽  
History Of

A study of 50 Chinese patients referred to the first lithium clinic in Hong Kong revealed a high prevalence of recurrent mania and rarely unipolar depression. A history of delusions and hallucinations, and re-diagnosis from schizophrenia to manic depressive psychosis, were common. Lithium was prescribed after 3.9 episodes of illness, and at a dosage of 1,191 mg despite a moderate serum level of 0.63 mmol/l. Laboratory monitoring was haphazard, and polypharmacy was common. This might pose unnecessary risks to some patients.

Psychiatric New-Patient Clinic Non-Attenders

1975 ◽  
Vol 127 (2) ◽  
pp. 160-162 ◽  
Author(s):  
R. Whyte
Keyword(s):  
Psychiatric Treatment ◽  
Depressed Type ◽  
Manic Depressive Psychosis ◽  
Self Selection ◽  
Manic Depressive ◽  
The Family ◽  
History Of

SummaryNon-attenders at a psychiatric new-patient clinic were seen and interviewed six weeks after the missed appointment, as were a group of controls who did attend.The non-attenders were more likely to have had frequent changes of occupation or belong to families where this was the case with the family breadwinner; a history of court conviction; and a history of previous psychiatric treatment. They were less likely to have improved since referral to the clinic; and to have a diagnosis of manic depressive psychosis, depressed type.The findings are discussed. There appears to be some self-selection, the most treatable patients keeping their appointments.

The effect of digoxin on the response to lithium therapy in mania

1982 ◽  
Vol 12 (1) ◽  
pp. 57-60 ◽  
Author(s):  
Catherine A. Chambers ◽  
Anne H. W. Smith ◽  
Graham J. Naylor
Keyword(s):  
Therapeutic Effect ◽  
Rating Scale ◽  
Lithium Carbonate ◽  
Lithium Therapy ◽  
The Other ◽  
Matching Placebo ◽  
Manic Depressive Psychosis ◽  
Manic Depressive ◽  
The Brain

SynopsisPatients suffering from manic-depressive psychosis, manic type (ICD 296·0), were treated with lithium carbonate and randomly allocated to two groups, one received digoxin and the other matching placebo for 7 days. Severity of mania was rated by psychiatrists on the Manic Rating Scale and Analogue Line on days 0 and 7 and by nurses daily on the Hargreaves Rating Scale, Psychotic Rating. Fourteen patients received digoxin and lithium carbonate and 14 patients received placebo and lithium carbonate. Improvement in the placebo lithium group was significantly greater than that in the digoxin lithium group. This trial suggests, therefore, that the effect of inhibition of membrane cation carrier is to reduce the response to lithium. This result is in keeping with our hypothesis that an increase in Na–K ATPase is essential to the therapeutic effect of lithium carbonate. It does not, however, exclude the possibility that the observations resulted from the inhibition by digoxin of lithium entry into the brain.

Bipolar Manic-Depressive Psychosis in Early Adolescence: A Case Report

1974 ◽  
Vol 125 (587) ◽  
pp. 416-417 ◽  
Author(s):  
Ian S. Berg ◽  
Roy P. Hullin ◽  
Michael N. E. Allsopp ◽  
Patrick O'Brien ◽  
Robert MacDonald
Keyword(s):  
Case Report ◽  
Early Adolescence ◽  
Plasma Levels ◽  
Attempted Suicide ◽  
Antidepressant Medication ◽  
Lithium Carbonate ◽  
School Phobia ◽  
Manic Depressive Psychosis ◽  
Manic Depressive ◽  
High Doses

A girl is briefly described who had typical bipolar manic-depressive psychosis starting unusually early at 14 years of age. Symptoms at the time of onset included severe anorexia, school phobia and attempted suicide, about the time of onset. She required unusually high doses of lithium carbonate to obtain adequate plasma levels, and there was a tendency for the administration of antidepressant medication to cause her to switch rapidly from depression to hypomania. The last two findings were shared by her father who also had bipolar manic-depressive psychosis.

scholarly journals Lithium carbonate toxicity in an elderly patient: a case report

2021 ◽  
Vol 10 (6) ◽  
pp. 766
Author(s):  
Ankit Bhardwaj ◽  
Vandana Roy ◽  
Manik S. Ghadlinge’s ◽  
Anubhav Dua
Keyword(s):  
Intensive Care Unit ◽  
Elderly Patient ◽  
Case Report ◽  
Gold Standard ◽  
Therapeutic Index ◽  
Lithium Carbonate ◽  
Lithium Toxicity ◽  
Narrow Therapeutic Index ◽  
Standard Drug ◽  
Level Monitoring

A case report of a 73-year-old man admitted in the intensive care unit with acute renal failure and lithium toxicity is reported. Lithium is a gold standard drug for bipolar disorder. It has a narrow therapeutic index and requires blood level monitoring frequently. Hemodialysis is the last resort in management of lithium toxicity but in between high rebound levels during the dialysis result in persistent CNS toxicity.

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