Bipolar Manic-Depressive Psychosis in Early Adolescence: A Case Report

1974 ◽  
Vol 125 (587) ◽  
pp. 416-417 ◽  
Author(s):  
Ian S. Berg ◽  
Roy P. Hullin ◽  
Michael N. E. Allsopp ◽  
Patrick O'Brien ◽  
Robert MacDonald
Keyword(s):  
Case Report ◽  
Early Adolescence ◽  
Plasma Levels ◽  
Attempted Suicide ◽  
Antidepressant Medication ◽  
Lithium Carbonate ◽  
School Phobia ◽  
Manic Depressive Psychosis ◽  
Manic Depressive ◽  
High Doses

A girl is briefly described who had typical bipolar manic-depressive psychosis starting unusually early at 14 years of age. Symptoms at the time of onset included severe anorexia, school phobia and attempted suicide, about the time of onset. She required unusually high doses of lithium carbonate to obtain adequate plasma levels, and there was a tendency for the administration of antidepressant medication to cause her to switch rapidly from depression to hypomania. The last two findings were shared by her father who also had bipolar manic-depressive psychosis.

Psychoses in Adult Mental Defectives: I. Manic Depressive Psychosis

1972 ◽  
Vol 120 (555) ◽  
pp. 205-212 ◽  
Author(s):  
A. H. Reid
Keyword(s):  
Mental Illness ◽  
Attempted Suicide ◽  
Mental Defective ◽  
High Grade ◽  
Dementia Praecox ◽  
Melancholic Depression ◽  
Manic Depressive Psychosis ◽  
Manic Depressive ◽  
Clear Cases ◽  
Mental Defectives

Hurd in 1888 described cases of mania, melancholia, folie circulaire and attempted suicide in mental defectives. Ireland in 1898 described three ‘imbecile lunatics’ who were ‘clear cases of melancholia’, and quoted an earlier physician, Wells, who in 1845 had seen ‘attacks of mania in cretins, as well as a peculiar suicidal form of this affliction, which prompts the wretched maniac to attempt self-destruction by throwing himself into the fire’. Clouston (1883) considered that ‘congenital imbeciles may have attacks of maniacal excitement or of melancholic depression—in fact are subject to them’. Kraepelin (1896, 1902) took the view that ‘imbecility may form the basis for the development of other psychoses such as manic-depressive insanity, the psychoses of involution and dementia praecox’. Gordon (1918) stated that mental defectives suffering from depression rarely express ideas of guilt or thoughts of suicide; manics lacked ‘quickness of comprehension of wit or humour or sarcasm’. He noted that depression was more common than mania and that recurrences tended to run true to type. Prideaux (1921) accepted that manic-depressive psychosis could occur in high-grade mental defectives, and drew attention to the increased incidence of conversion hysteria in patients of low intelligence. Medow (1925) observed that mental defectives could manifest all the types of mental illness seen in people of normal intelligence but in the defective mental illness had a silly, fantastic, nonsensical colouring. Neustadt (1928) put forward the view that the typical psychoses of the mental defective were acute episodic states of excitement.

Medical audit in an elderly depressed cohort

1992 ◽  
Vol 9 (1) ◽  
pp. 62-66 ◽  
Author(s):  
Peter Donnelly
Keyword(s):  
Risk Group ◽  
Antidepressant Medication ◽  
The Elderly ◽  
Depressive Illness ◽  
Medical Audit ◽  
Retrospective Case ◽  
Manic Depressive Psychosis ◽  
Manic Depressive ◽  
Specialist Treatment ◽  
Elderly Cohort

AbstractMedical audit was carried out to evaluate drug therapy in a cohort of depressed patients admitted to a functional ward for the elderly. A retrospective case note study was carried out in 61 consecutive admissions with a diagnosis of depression. Seventeen of the 41 patients (41%) with a diagnosis of Manic Depressive Psychosis were not taking antidepressant medication on admission. Of the 11 patients who received Electroconvulsive Therapy seven (64%) did so under Section 3 of the Mental Health Act. Four of the 41 patients (10%) with a diagnosis of Manic Depressive Psychosis were not on prophylactic antidepressants or lithium on discharge. Seventeen of the patients (28%) were taking benzodiazepine hypnotics on admission, and 14 of these were discharged on the same type and dosage. There were no patients on more than one type of antidepressant or antipsychotic at any one time. These findings reflect deficiencies in the general practice and specialist treatment of depressive illness in an elderly cohort. The need for on-going audit in this at risk group is emphasized.

Lithium Toxicity and Mefenamic Acid

1987 ◽  
Vol 151 (6) ◽  
pp. 847-848 ◽  
Author(s):  
R. K. Shelley
Keyword(s):  
Elderly Patient ◽  
Cardiac Failure ◽  
Mefenamic Acid ◽  
Lithium Carbonate ◽  
Lithium Toxicity ◽  
Vulnerability Factors ◽  
Glomerular Function ◽  
Manic Depressive Psychosis ◽  
Manic Depressive ◽  
History Of

An elderly patient with bipolar manic-depressive psychosis, stabilised satisfactorily on lithium carbonate, developed acute symptoms of lithium toxicity shortly after commencing mefenamic acid. Vulnerability factors for the interaction may have included age, history of cardiac failure, and impaired glomerular function. It is hypothesised that the interaction may have been mediated by inhibition of prostaglandin activity.

The effect of digoxin on the response to lithium therapy in mania

1982 ◽  
Vol 12 (1) ◽  
pp. 57-60 ◽  
Author(s):  
Catherine A. Chambers ◽  
Anne H. W. Smith ◽  
Graham J. Naylor
Keyword(s):  
Therapeutic Effect ◽  
Rating Scale ◽  
Lithium Carbonate ◽  
Lithium Therapy ◽  
The Other ◽  
Matching Placebo ◽  
Manic Depressive Psychosis ◽  
Manic Depressive ◽  
The Brain

SynopsisPatients suffering from manic-depressive psychosis, manic type (ICD 296·0), were treated with lithium carbonate and randomly allocated to two groups, one received digoxin and the other matching placebo for 7 days. Severity of mania was rated by psychiatrists on the Manic Rating Scale and Analogue Line on days 0 and 7 and by nurses daily on the Hargreaves Rating Scale, Psychotic Rating. Fourteen patients received digoxin and lithium carbonate and 14 patients received placebo and lithium carbonate. Improvement in the placebo lithium group was significantly greater than that in the digoxin lithium group. This trial suggests, therefore, that the effect of inhibition of membrane cation carrier is to reduce the response to lithium. This result is in keeping with our hypothesis that an increase in Na–K ATPase is essential to the therapeutic effect of lithium carbonate. It does not, however, exclude the possibility that the observations resulted from the inhibition by digoxin of lithium entry into the brain.

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