Psychiatric Illness in First-Degree Relatives of Patients with Paranoid Psychosis, Schizophrenia and Medical Illness

1985 ◽  
Vol 147 (5) ◽  
pp. 524-531 ◽  
Author(s):  
Kenneth S. Kendler ◽  
Catherine C. Masterson ◽  
Kenneth L. Davis
Keyword(s):  
Personality Disorder ◽  
Psychiatric Illness ◽  
Delusional Disorder ◽  
Medical Illness ◽  
Schizotypal Personality ◽  
First Degree Relatives ◽  
The Family ◽  
Paranoid Personality Disorder ◽  
Schizophrenic Patients ◽  
Paranoid Psychosis

This study examines the respective morbid risk for psychiatric illness determined by the family history method in the first-degree relatives of medical controls and patients with delusional disorder (paranoid psychosis) and schizophrenia. The morbid risk for schizophrenia and schizoid-schizotypal personality disorder was significantly greater in the relatives of the schizophrenic patients than in those of the delusional disorder or medical control patients, but no difference in the risk for affective illness or alcoholism was found in the three groups of relatives. Paranoid personality disorder was significantly more common in the relatives of the delusional disorder patients than in those of the medical controls. These results support the familial independence of delusional disorder and schizophrenia.

Psychiatric Morbidity in the First-Degree Relatives of Schizophrenic Patients

1993 ◽  
Vol 162 (5) ◽  
pp. 672-678 ◽  
Author(s):  
Shashjit L. Varma ◽  
Indira Sharma
Keyword(s):  
Psychiatric Illness ◽  
Psychiatric Morbidity ◽  
Schizotypal Personality ◽  
First Degree Relatives ◽  
Paranoid Personality Disorder ◽  
Paranoid Personality ◽  
Schizophrenic Patients ◽  
Biological Relationship ◽  
Morbidity Risks ◽  
And Control

First-degree relatives (FDRs) of 1018 schizophrenic and 812 control probands were investigated. Psychiatric morbidity was present in 34.8% of FDRs of schizophrenic probands and in 9.2% of FDRs of controls. There was significantly more psychiatric illness in the siblings and parents than in the offspring of both schizophrenic and control subjects. The morbidity risks for schizoid-schizotypal personality disorders, cannabis-use disorder and paranoid personality disorder were significantly higher in the FDRs of schizophrenic patients than in those of controls, suggesting a biological relationship.

scholarly journals Auditory steady state response in the schizophrenia, first-degree relatives, and schizotypal personality disorder

2012 ◽  
Vol 136 (1-3) ◽  
pp. 143-149 ◽  
Author(s):  
Olga Rass ◽  
Jennifer K. Forsyth ◽  
Giri P. Krishnan ◽  
William P. Hetrick ◽  
Mallory J. Klaunig ◽  
...  
Keyword(s):  
Steady State ◽  
Personality Disorder ◽  
Schizotypal Personality Disorder ◽  
Steady State Response ◽  
Schizotypal Personality ◽  
State Response ◽  
First Degree Relatives ◽  
Auditory Steady State Response

Personality Disorders

2017 ◽  
Author(s):  
Waqar Rizvi
Keyword(s):  
Personality Disorder ◽  
Borderline Personality ◽  
Obsessive Compulsive ◽  
Dependent Personality Disorder ◽  
Schizotypal Personality ◽  
Histrionic Personality Disorder ◽  
Dependent Personality ◽  
Schizoid Personality Disorder ◽  
Paranoid Personality Disorder ◽  
Obsessive Compulsive Personality Disorder

In this chapter essential aspects of personality disorder will be reviewed including paranoid personality disorder, schizoid personality disorder, schizotypal personality disorder, borderline personality disorder, histrionic personality disorder, narcissistic personality disorder, Avoidant personality disorder, dependent personality disorder, obsessive-compulsive personality disorder and antisocial personality disorder

Specific types of personality disorder

2012 ◽  
pp. 861-881 ◽  
Author(s):  
José Luis Carrasco ◽  
Dusica Lecic-Tosevski
Keyword(s):  
Personality Disorder ◽  
Personality Disorders ◽  
Personality Change ◽  
Obsessive Compulsive ◽  
Schizotypal Personality ◽  
General Medical Condition ◽  
Personality Changes ◽  
Paranoid Personality Disorder ◽  
Paranoid Personality ◽  
Cluster B Personality Disorders

This chapter begins by discussing the epidemiology, aetiology, clinical picture, course, differential diagnosis, and treatment of various Cluster A personality disorders (Paranoid personality disorder, paranoid personality disorder, schizotypal personality disorder), Cluster B personality disorders (antisocial personality disorder, borderline personality disorder (BPD), histrionic personality disorder, narcissistic personality disorder) and Cluster C personality disorders (avoidant personality disorder, dependent personality disorder (JLC), and obsessive–compulsive (anankastic) personality disorder). Other personality disorders (not included in DSM-IV) are also covered, including passive–aggressive (negativistic) personality disorder, self-defeating (masochistic) personality disorder, sadistic personality disorder, depressive personality disorder, and personality changes, including enduring personality changes after traumatic experiences and personality change due to a general medical condition (JLC).

Metacognition-oriented therapy for psychosis: The case of a woman with delusional disorder and paranoid personality disorder.

2012 ◽  
Vol 22 (4) ◽  
pp. 314-329 ◽  
Author(s):  
Giampaolo Salvatore ◽  
Benedetta Russo ◽  
Marina Russo ◽  
Raffaele Popolo ◽  
Giancarlo Dimaggio
Keyword(s):  
Personality Disorder ◽  
Delusional Disorder ◽  
Paranoid Personality Disorder ◽  
Paranoid Personality

Family History Study of Anorexia Nervosa and Bulimia

1983 ◽  
Vol 142 (2) ◽  
pp. 133-137 ◽  
Author(s):  
James I. Hudson ◽  
Harrison G. Pope ◽  
Jeffrey M. Jonas ◽  
Deborah Yurgelun-Todd
Keyword(s):  
Bipolar Disorder ◽  
Anorexia Nervosa ◽  
Eating Disorder ◽  
Borderline Personality Disorder ◽  
Family History ◽  
Personality Disorder ◽  
Affective Disorder ◽  
Psychiatric Illness ◽  
Borderline Personality ◽  
The Family

SummaryThe 420 first-degree relatives of 14 patients with anorexia nervosa, 55 patients with bulimia, and 20 patients with both disorders were evaluated for the presence of psychiatric illness, using DSM-III criteria, by the family history method. The morbid risk for affective disorder in the families of the eating disorder probands was similar to that found in the families of patients with bipolar disorder; but was significantly greater than that found in the families of patients with schizophrenia or borderline personality disorder. These results add to the growing evidence that anorexia nervosa and bulimia are closely related to affective disorder.

Parent-Child Concordance with Respect to Sex and Diagnosis in Schizophrenia and Manic-Depressive Psychosis

1973 ◽  
Vol 123 (577) ◽  
pp. 653-658 ◽  
Author(s):  
Anne Powell ◽  
Nancy M. Thomson ◽  
David J. Hall ◽  
Linda S. Wilson
Keyword(s):  
Social Learning ◽  
Psychiatric Illness ◽  
Family Members ◽  
Psychiatric Research ◽  
Manic Depressive Psychosis ◽  
First Degree Relatives ◽  
Manic Depressive ◽  
The Family ◽  
Physical Attributes ◽  
Diagnostic Concordance

In the search for an explanation of the aetiology of psychiatric illness, the study of the family as a unit for psychiatric research is becoming increasingly necessary. That family members resemble one another in many respects seems an intuitively correct idea. Children resemble their parents in both physical attributes and temperament; the former is mainly attributed to heredity and the latter to an interaction of heredity and social learning. Previous psychiatric studies of the family have indicated two areas for further investigation: firstly, sex concordance, and secondly diagnostic concordance among psychiatrically ill first degree relatives. The literature relating to these areas is abundant, and the main conclusions are summarized below.

scholarly journals Review of pharmacologic treatment in cluster A personality disorders

2016 ◽  
Vol 6 (2) ◽  
pp. 75-81 ◽  
Author(s):  
Jessa Koch ◽  
Taylor Modesitt ◽  
Melissa Palmer ◽  
Sarah Ward ◽  
Bobbie Martin ◽  
...  
Keyword(s):  
Personality Disorder ◽  
Personality Disorders ◽  
Schizotypal Personality Disorder ◽  
Pharmacologic Treatment ◽  
Schizotypal Personality ◽  
Schizoid Personality ◽  
Schizoid Personality Disorder ◽  
Paranoid Personality Disorder ◽  
Paranoid Personality ◽  
Cluster A

Abstract Introduction: A personality disorder is a pervasive and enduring pattern of behaviors that impacts an individual's social, occupational, and overall functioning. Specifically, the cluster A personality disorders include paranoid personality disorder, schizoid personality disorder, and schizotypal personality disorder. Patients with cluster A personality disorders tend to be isolative and avoid relationships. The quality of life may also be reduced in these individuals, which provokes the question of how to treat patients with these personality disorders. The purpose of this review is to evaluate the current literature for pharmacologic treatments for the cluster A personality disorders. Methods: A Medline/PubMed and Ovid search was conducted to identify literature on the psychopharmacology of paranoid personality disorder, schizoid personality disorder, and schizotypal personality disorder. There were no exclusions in terms of time frame from article publication or country of publication, in order to provide a comprehensive analysis; however, only articles that contained information on the cluster A disorders were included. Results: Minimal evidence regarding pharmacotherapy in paranoid and schizoid personality disorders was found. Literature was available for pharmacologic treatment of schizotypal personality disorder. Studies evaluating the use of olanzapine, risperidone, haloperidol, fluoxetine, and thiothixene did yield beneficial results; however, treatment with such agents should be considered on a case-by-case basis. Discussion: Most of the literature analyzed in this review presented theoretical ideas of what may constitute the neurobiologic factors of personality and what treatments may address these aspects. Further research is needed to evaluate specific pharmacologic treatment in the cluster A personality disorders. At this time, treatment with pharmacologic agents is based on theory rather than evidence.

Heritability of Schizophrenia

1994 ◽  
Vol 164 (4) ◽  
pp. 481-486 ◽  
Author(s):  
O. Gureje ◽  
R. Bamidele ◽  
Y. A. Aderibigbe
Keyword(s):  
Family History ◽  
Affective Psychoses ◽  
First Degree Relatives ◽  
The Family ◽  
Schizophrenic Patients ◽  
Manic Patients

Thirty-six consecutively admitted patients with schizophrenia and 20 with mania were studied for the morbid risk of psychosis in their first-degree relatives. Using the family history method of ascertainment, the morbid risk for schizophrenia in the relatives of schizophrenic probands was 4.12% compared with 1.42% in the relatives of manic probands. While this difference was not statistically significant, that between the morbid risk for affective psychoses in the relatives of manic patients (7.81%) was significantly higher than for the relatives of schizophrenic patients (0%).

The biological basis of schizotypal personality disorder

2000 ◽  
Vol 17 (3) ◽  
pp. 106-109
Author(s):  
Richelle M Kirrane ◽  
Larry J Siever
Keyword(s):  
Cognitive Impairment ◽  
Personality Disorder ◽  
Social Isolation ◽  
Brain Dysfunction ◽  
Schizotypal Personality Disorder ◽  
Biological Basis ◽  
Schizotypal Personality ◽  
Schizophrenia Spectrum ◽  
Schizophrenic Patients ◽  
Schizotypal Disorder

AbstractSchizotypal personality disorder is the DSM equivalent of the ICD category schizotypal disorder. It may be seen as part of the schizophrenia spectrum of disorders. Patients with schizotypal personality disorder (SPD) share many features with schizophrenic patients. These include symptoms of social isolation and cognitive impairment. They also share imaging and biochemical evidence of brain dysfunction, and genetic similarities. SPD patients, however, for some reason do not become chronically psychotic. The study of schizotypal patients is of great importance in attempting to clarify the genetic and biological basis of the schizophrenia spectrum. It is also important in helping to delineate the differences between schizophrenic and schizotypal patients, and to distinguish those factors that protect the schizotypal patient from becoming floridly psychotic. In this article we present recent findings regarding the biological basis of schizotypal personality disorder. We illustrate the contribution of these findings to our understanding of risk and protective factors in the schizophrenia spectrum.

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