Parent-Child Concordance with Respect to Sex and Diagnosis in Schizophrenia and Manic-Depressive Psychosis

1973 ◽  
Vol 123 (577) ◽  
pp. 653-658 ◽  
Author(s):  
Anne Powell ◽  
Nancy M. Thomson ◽  
David J. Hall ◽  
Linda S. Wilson
Keyword(s):  
Social Learning ◽  
Psychiatric Illness ◽  
Family Members ◽  
Psychiatric Research ◽  
Manic Depressive Psychosis ◽  
First Degree Relatives ◽  
Manic Depressive ◽  
The Family ◽  
Physical Attributes ◽  
Diagnostic Concordance

In the search for an explanation of the aetiology of psychiatric illness, the study of the family as a unit for psychiatric research is becoming increasingly necessary. That family members resemble one another in many respects seems an intuitively correct idea. Children resemble their parents in both physical attributes and temperament; the former is mainly attributed to heredity and the latter to an interaction of heredity and social learning. Previous psychiatric studies of the family have indicated two areas for further investigation: firstly, sex concordance, and secondly diagnostic concordance among psychiatrically ill first degree relatives. The literature relating to these areas is abundant, and the main conclusions are summarized below.

Family Psychiatric Morbidity, Parental Deprivation and Socio-Economic Status in Cases of Mania

1975 ◽  
Vol 126 (2) ◽  
pp. 191-192 ◽  
Author(s):  
H. D. Chopra
Keyword(s):  
Affective Disorder ◽  
Psychiatric Illness ◽  
Economic Status ◽  
Psychiatric Morbidity ◽  
Parental Death ◽  
Manic Depressive Psychosis ◽  
Socio Economic Status ◽  
First Degree Relatives ◽  
Manic Depressive ◽  
Manic Patients

Manic-depressive psychosis is considered to comprise two different clinical entities, bipolar and monopolar. This dichotomy is based mainly on Western clinical material. The present study aimed at eliciting any differences that might exist between monopolar and bipolar manic patients in respect of three factors: (i) occurrence of psychiatric illness in first degree relatives; (ii) parental death before the patient's 15th birthday; and (iii) socio-economic status of the patient. Venkoba Rao (1973) studied the differences between monopolar and bipolar endogenous depressives on three factors: occurrence of affective disorder (including suicide) in first degree relatives; parental loss before the patient's 12th birthday, and the extent of ‘jointness' of the patient's family.

Manic patients with schizophrenic or paranoid symptoms

1980 ◽  
Vol 10 (1) ◽  
pp. 73-83 ◽  
Author(s):  
I. F. Brockington ◽  
S. Wainwright ◽  
R. E. Kendell
Keyword(s):  
Effective Treatment ◽  
Outcome Measures ◽  
Poor Prognosis ◽  
Hospital Admissions ◽  
Full Recovery ◽  
Manic Depressive Psychosis ◽  
First Degree Relatives ◽  
Manic Depressive ◽  
Paranoid Symptoms ◽  
Manic Patients

SYNOPSISA study of 32 patients meeting criteria for ‘schizomanic’ psychosis is described. These psychoses account for about 1 % of hospital admissions. Very few first-degree relatives had either schizophrenia or mania. Lithium seemed an effective treatment. Twenty-four patients made a full recovery, and the series as a whole was closer to manic depressive psychosis than schizophrenia on all outcome measures. Some diagnostic clues are suggested to help the clinician to recognize the patients with a poor prognosis.These findings are in line with other studies, and suggest that most of these patients should be regarded as manic. This conclusion should lead to some revision of present ideas on the incidence and diagnosis of mania.

Assortative mating among in-patients with primary affective disorder

1982 ◽  
Vol 12 (4) ◽  
pp. 753-764 ◽  
Author(s):  
Kathleen Ries Merikangas ◽  
Duane G. Spiker
Keyword(s):  
Assortative Mating ◽  
Affective Disorders ◽  
Psychiatric Illness ◽  
Marital Interaction ◽  
Affective Illness ◽  
First Degree Relatives ◽  
Diagnostic Concordance ◽  
Primary Affective Disorders ◽  
Bipolar Patients ◽  
High Degree

SynopsisAssortative mating among 56 married in-patients with primary affective disorders and their spouses was studied by determining the prevalence of psychiatric illness among the spouses by means of direct interviews and standardized diagnostic criteria. A high degree of assortative mating among both male and female patients was observed for total psychiatric illness, broad spectrum affective illness and major depression. A significantly higher prevalence of psychiatric and affective illness was found among the first-degree relatives of the ill spouses when compared with the first-degree relatives of the well spouses. There was a high degree of diagnostic concordance between the patients and spouses for both affective illness and alcoholism, with a higher degree of assortative mating among bipolar patients than among unipolar patients. The finding in this study of an increased prevalence of psychiatric disorder in the first-degree relatives of the ill spouses would support the hypothesis that there is a tendency for individuals with a predisposition to psychiatric illness to marry, rather than the existence of a marital interaction which causes an increased concordance for psychiatric illness.

Is puerperal psychosis the same as bipolar manic-depressive disorder? A family study

1989 ◽  
Vol 19 (3) ◽  
pp. 637-647 ◽  
Author(s):  
C. Dean ◽  
R. J. Williams ◽  
I. F. Brockington
Keyword(s):  
Depressive Disorder ◽  
Psychiatric Illness ◽  
Age Of Onset ◽  
Hospital Treatment ◽  
Mixed Group ◽  
Puerperal Psychosis ◽  
First Degree Relatives ◽  
Manic Depressive ◽  
Genetically Determined ◽  
Depressive Group

SynopsisThe first degree relatives of three groups of women were interviewed; 51 women who had had an illness within two weeks of childbirth and no non-puerperal episodes (the puerperal group), 33 who had puerperal and non-puerperal episodes (the mixed group), and 19 women with bipolar manic-depressive disorder who had non-puerperal episodes only (the manic-depressive group).Over 60% of the affected relatives in all three groups had affective illnesses; in the main these were not puerperal. There were significantly more first degree relatives who had had general practitioner or hospital treatment for psychiatric illness in the puerperal group and in the mixed group than in the manic-depressive group. The puerperal patients had a better prognosis in terms of their illness (number of relapses and time on medication), work functioning and social functioning than the manic-depressive group and the mixed group. The mixed group had an earlier age of onset than the manic-depressive group and the puerperal group. The hypothesis that puerperal psychosis is the same as bipolar manic-depressive disorder was not upheld. The mixed group and the puerperal group were similar with respect to the risk in first degree relatives but differed in terms of prognosis.There were no significant differences between the groups with respect to puerperal episodes in first-degree relatives, although the rate of puerperal psychosis in the first-degree relatives of the puerperal patients was significantly greater than in the general population. The hypothesis that there is a specific genetically determined puerperal psychosis was not supported. Women who had had an illness with an onset within two weeks of childbirth (mixed and puerperal) subsequently had an illness following 36% of their childbirths. In women who had had puerperal and non-puerperal episodes (mixed) the risk was higher; over 50 % of deliveries in these women were followed by psychiatric illness.

Psychiatric Illness in First-Degree Relatives of Patients with Paranoid Psychosis, Schizophrenia and Medical Illness

1985 ◽  
Vol 147 (5) ◽  
pp. 524-531 ◽  
Author(s):  
Kenneth S. Kendler ◽  
Catherine C. Masterson ◽  
Kenneth L. Davis
Keyword(s):  
Personality Disorder ◽  
Psychiatric Illness ◽  
Delusional Disorder ◽  
Medical Illness ◽  
Schizotypal Personality ◽  
First Degree Relatives ◽  
The Family ◽  
Paranoid Personality Disorder ◽  
Schizophrenic Patients ◽  
Paranoid Psychosis

This study examines the respective morbid risk for psychiatric illness determined by the family history method in the first-degree relatives of medical controls and patients with delusional disorder (paranoid psychosis) and schizophrenia. The morbid risk for schizophrenia and schizoid-schizotypal personality disorder was significantly greater in the relatives of the schizophrenic patients than in those of the delusional disorder or medical control patients, but no difference in the risk for affective illness or alcoholism was found in the three groups of relatives. Paranoid personality disorder was significantly more common in the relatives of the delusional disorder patients than in those of the medical controls. These results support the familial independence of delusional disorder and schizophrenia.

Psychiatric New-Patient Clinic Non-Attenders

1975 ◽  
Vol 127 (2) ◽  
pp. 160-162 ◽  
Author(s):  
R. Whyte
Keyword(s):  
Psychiatric Treatment ◽  
Depressed Type ◽  
Manic Depressive Psychosis ◽  
Self Selection ◽  
Manic Depressive ◽  
The Family ◽  
History Of

SummaryNon-attenders at a psychiatric new-patient clinic were seen and interviewed six weeks after the missed appointment, as were a group of controls who did attend.The non-attenders were more likely to have had frequent changes of occupation or belong to families where this was the case with the family breadwinner; a history of court conviction; and a history of previous psychiatric treatment. They were less likely to have improved since referral to the clinic; and to have a diagnosis of manic depressive psychosis, depressed type.The findings are discussed. There appears to be some self-selection, the most treatable patients keeping their appointments.

Psychiatric Illness in a Large Family with Familial Hyperparathyroidism

1970 ◽  
Vol 117 (541) ◽  
pp. 693-698 ◽  
Author(s):  
Thomas A. Flanagan ◽  
Donald W. Goodwin ◽  
Philip Alderson
Keyword(s):  
Primary Hyperparathyroidism ◽  
Serum Calcium ◽  
Psychiatric Illness ◽  
Incidental Finding ◽  
Family Members ◽  
Elevated Serum ◽  
Large Family ◽  
The Family ◽  
Familial Hyperparathyroidism

In 1964 Cutler et al. (1) reported on a family in which 11 members apparently had primary hyperparathyroidism. Seven cases were diagnosed at surgery; four other members had elevated serum calcium and other evidence of the disease. It was noted as an incidental finding that two of the affected members also suffered from severe psychiatric illness. The present study is a six-year follow-up investigation of the family from a psychiatric viewpoint, using non-hyperparathyroidism family members as controls to explore the possible relation of hyperparathyroidism to psychiatric illness.

scholarly journals Frequency of thyroid carcinoma and thyroid autoimmunity in first-degree relatives of patients with papillary thyroid carcinoma: A single center experience

2011 ◽  
Vol 55 (5) ◽  
pp. 326-330 ◽  
Author(s):  
Elaine Maria dos Santos Gomes ◽  
Fernanda Vaisman ◽  
Ana Paula Vidal ◽  
Rossana Corbo ◽  
Manuel Domingos Gonçalves da Cruz ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Thyroid Carcinoma ◽  
Thyroid Dysfunction ◽  
Thyroid Autoimmunity ◽  
Family Members ◽  
Needle Aspiration ◽  
First Degree Relatives ◽  
Single Center Experience ◽  
Ultrasound Evaluation ◽  
The Family

OBJECTIVE: To evaluate the frequency of thyroid cancer and thyroid dysfunction in first-degree relatives of thyroid cancer patients, and to determine if there is a difference between familial and sporadic thyroid cancer. SUBJECTS AND METHODS: Fifteen first-degree relatives of seven families with at least two family members with thyroid cancer (TC) were compared with 128 first-degree relatives of 45 families with only one family member affected. Laboratory and ultrasound evaluation, fine-needle aspiration biopsy and thyroid surgery were used as normally done in clinical practice. RESULTS: Thyroid dysfunction was similar between the two groups. The frequency of TC and autoimmunity in the group that had two relatives with known thyroid cancer was higher, compared with the families that had sporadic thyroid cancer among their family members (40% vs. 2%, p = 0.0001). CONCLUSION: Frequency of TC increases when more than one member of the family is affected. These findings suggest that these relatives should be screened more frequently than individuals in families in which only one case of TC is observed.

Short-Cycle Manic-Depressive Psychosis in a Mentally Handicapped Child without Family History

1987 ◽  
Vol 151 (4) ◽  
pp. 554-555 ◽  
Author(s):  
C. M. Linter
Keyword(s):  
Family History ◽  
Psychiatric Illness ◽  
Depressive Illness ◽  
Handicapped Child ◽  
Manic Depressive Illness ◽  
Mentally Handicapped ◽  
Short Cycle ◽  
Manic Depressive Psychosis ◽  
Mental Handicap ◽  
Manic Depressive

Diagnosis of classic psychiatric illness in mentally handicapped individuals remains difficult. Manic-depressive illness has previously been reported in both pre-pubertal and pubertal children with a mental handicap and with a family history. This paper reports a case of manic-depressive psychosis in childhood, with no family history, short-cycle mood swings and good response to lithium therapy.

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