scholarly journals Out-of-hospital surface cooling with a cooling-blanket to induce mild hypothermia in humans after cardiac arrest: a feasibility trial

Critical Care ◽  
2007 ◽  
Vol 11 (Suppl 2) ◽  
pp. P327
Author(s):  
T Uray ◽  
R Malzer ◽  
A Auer ◽  
A Zajicek ◽  
F Sterz ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Mild Hypothermia ◽  
Feasibility Trial ◽  
Surface Cooling

scholarly journals Surface cooling for induction of mild hypothermia in conscious healthy volunteers - a feasibility trial

Critical Care ◽  
2011 ◽  
Vol 15 (5) ◽  
pp. R248 ◽  
Author(s):  
Christoph Testori ◽  
Fritz Sterz ◽  
Wilhelm Behringer ◽  
Alexander Spiel ◽  
Christa Firbas ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Mild Hypothermia ◽  
Feasibility Trial ◽  
Surface Cooling

scholarly journals Surface Cooling for Rapid Induction of Mild Hypothermia After Cardiac Arrest: Design Determines Efficacy

2010 ◽  
Vol 17 (4) ◽  
pp. 360-367 ◽  
Author(s):  
Thomas Uray ◽  
Moritz Haugk ◽  
Fritz Sterz ◽  
Jasmin Arrich ◽  
Nina Richling ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Mild Hypothermia ◽  
Surface Cooling ◽  
Rapid Induction

Abstract P136: Tracheal Temperature for Monitoring Core Temperature during Mild Hypothermia in Pigs

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Danica Krizanac ◽  
Moritz Haugk ◽  
Wolfgang Weihs ◽  
Michael Holzer ◽  
Keywan Bayegan ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Pulmonary Artery ◽  
Temperature Measurement ◽  
Core Temperature ◽  
Tracheal Tube ◽  
Mild Hypothermia ◽  
Temperature Monitoring ◽  
Surface Cooling ◽  
Significant Difference ◽  
Mean Differences

Purpose of the stud y: Early out-of-hospital induction of mild hypothermia after cardiac arrest needs an easy to use and accurate core temperature monitoring, which might be achievable with tracheal temperature measurement. The aim of the study was to evaluate which tracheal temperature site (Ttra) reflects best pulmonary artery temperature (Tpa) during the induction of mild hypothermia. Methods: Eight pigs (29 –38 kg) were anesthetized and intubated with a specially designed endotracheal tube with three temperature probes: Ttra1 was attached to the wall of the tube, 1 cm proximal to the cuff-balloon, without contact to the mucosa; Ttra2 and Ttra3 were placed on the cuff-balloon with tight contact to the mucosa, whereas Ttra3 was covered by a plastic tube to protect the mucosa. Core temperature was measured with a pulmonary artery catheter (Tpa). Pigs were cooled with a new surface cooling device (Emcoolspad®, Vienna, Austria). Data are presented as mean (±SD), and mean differences (95% CI). Results: Emcoolspad® decreased Tpa from 38.5°C to 33°C in 31±10 min, which translates into a cooling rate of 11.9±3.8°C/h. Overall mean differences of tracheal temperatures to pulmonary artery temperature (Tpa) are shown in table 1 . Ttra 1 showed the least difference to Tpa, followed by Ttra 2 and Ttra 3. There was a significant difference in temperature differences (Ttra-Tpa) related to temperature measurement site on the tracheal tube (p<0.007). Conclusions: The temperature probe proximal of the cuff (Ttra 1) reflects best pulmonary artery temperature. It seems to be an accurate surrogate for core temperature during the induction of mild hypothermia. The industry is asked to provide a tracheal tube with a temperature sensor for simple temperature monitoring during fast cooling to facilitate the implementation of mild hypothermia after cardiac arrest in the out-of-hospital setting.

scholarly journals Short Duration Combined Mild Hypothermia Improves Resuscitation Outcomes in a Porcine Model of Prolonged Cardiac Arrest

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Tao Yu ◽  
Zhengfei Yang ◽  
Heng Li ◽  
Youde Ding ◽  
Zitong Huang ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Short Duration ◽  
Porcine Model ◽  
Mild Hypothermia ◽  
Survival Outcomes ◽  
Surface Cooling ◽  
Neurological Outcomes ◽  
Group A ◽  
Combined Cooling ◽  
Neuron Apoptosis

Objective.In this study, our aim was to investigate the effects of combined hypothermia with short duration maintenance on the resuscitation outcomes in a porcine model of ventricular fibrillation (VF).Methods.Fourteen porcine models were electrically induced with VF and untreated for 11 mins. All animals were successfully resuscitated manually and then randomized into two groups: combined mild hypothermia (CH group) and normothermia group (NT group). A combined hypothermia of ice cold saline infusion and surface cooling was implemented in the animals of the CH group and maintained for 4 hours. The survival outcomes and neurological function were evaluated every 24 hours until a maximum of 96 hours. Neuron apoptosis in hippocampus was analyzed.Results.There were no significant differences in baseline physiologies and primary resuscitation outcomes between both groups. Obvious improvements of cardiac output were observed in the CH group at 120, 180, and 240 mins following resuscitation. The animals demonstrated better survival at 96 hours in the CH group when compared to the NT group. In comparison with the NT group, favorable neurological functions were observed in the CH group.Conclusion.Short duration combined cooling initiated after resuscitation improves survival and neurological outcomes in a porcine model of prolonged VF.

Does the evidence support the use of mild hypothermia after cardiac arrest? Yes

BMJ ◽  
2011 ◽  
Vol 343 (sep22 2) ◽  
pp. d5830-d5830 ◽  
Author(s):  
J. P. Nolan ◽  
J. Soar
Keyword(s):  
Cardiac Arrest ◽  
Mild Hypothermia

scholarly journals Mild hypothermia after cardiac arrest in dogs does not affect postarrest multifocal cerebral hypoperfusion.

Stroke ◽  
1993 ◽  
Vol 24 (10) ◽  
pp. 1590-1597 ◽  
Author(s):  
K Oku ◽  
F Sterz ◽  
P Safar ◽  
D Johnson ◽  
W Obrist ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Mild Hypothermia ◽  
Cerebral Hypoperfusion

scholarly journals Our experiences with therapeutic hypothermia

2007 ◽  
Vol 60 (9-10) ◽  
pp. 431-435 ◽  
Author(s):  
Milovan Petrovic ◽  
Ilija Srdanovic ◽  
Gordana Panic ◽  
Tibor Canji ◽  
Tihomir Miljevic
Keyword(s):  
Cardiac Arrest ◽  
Therapeutic Hypothermia ◽  
Neurological Outcome ◽  
Mild Hypothermia ◽  
Acute Myocarditis ◽  
Neuroprotective Effect ◽  
Sudden Cardiac Arrest ◽  
Neurological Recovery ◽  
Global Cerebral Ischemia ◽  
Resuscitation Guidelines

Introduction. The single most important clinically relevant cause of global cerebral ischemia is cardiac arrest. The estimated rate of sudden cardiac arrest is between 40 and 130 cases per 100.000 people per year. Almost 80% of patients initially resuscitated from cardiac arrest remain comatose for more than one hour. One year after cardiac arrest only 10-30% of these patients survive with good neurological outcome. The ability to survive anoxic no-flow states is dramatically increased with protective and preservative hypothermia. The results of clinical studies show a marked neuroprotective effect of mild hypothermia in resuscitation. Material and Methods. In our clinic, 12 patients were treated with therapeutic hypothermia. A combination of intravascular and external method of cooling was used according to the ILCOR (International Liaison Committee on Resuscitation) guidelines. The target temperature was 33oC, while the duration of cooling was 24 hours. After that, passive rewarming was allowed. All patients also received other necessary therapy. Results. Six patients (50%) had a complete neurological recovery. Two patients (16.6%) had partial neurological recovery. Four patients (33.3%) remained comatose. Five patients (41.66%) survived, while 7 (58.33%) patients died. The main cause of cardiac arrest was acute myocardial infarction (91.6%). One patient had acute myocarditis. Conclusion. Mild resuscitative hypothermia after cardiac arrest improves neurological outcome and reduces mortality in comatose survivors. .

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