scholarly journals Surface cooling for induction of mild hypothermia in conscious healthy volunteers - a feasibility trial

Critical Care ◽  
2011 ◽  
Vol 15 (5) ◽  
pp. R248 ◽  
Author(s):  
Christoph Testori ◽  
Fritz Sterz ◽  
Wilhelm Behringer ◽  
Alexander Spiel ◽  
Christa Firbas ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Mild Hypothermia ◽  
Feasibility Trial ◽  
Surface Cooling

Surface cooling for induction of mild hypothermia in conscious healthy volunteers

Resuscitation ◽  
2010 ◽  
Vol 81 (2) ◽  
pp. S65
Author(s):  
C. Testori ◽  
F. Sterz ◽  
W. Behringer ◽  
M. Holzer ◽  
B. Jilma
Keyword(s):  
Healthy Volunteers ◽  
Mild Hypothermia ◽  
Surface Cooling

scholarly journals Out-of-hospital surface cooling with a cooling-blanket to induce mild hypothermia in humans after cardiac arrest: a feasibility trial

Critical Care ◽  
2007 ◽  
Vol 11 (Suppl 2) ◽  
pp. P327
Author(s):  
T Uray ◽  
R Malzer ◽  
A Auer ◽  
A Zajicek ◽  
F Sterz ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Mild Hypothermia ◽  
Feasibility Trial ◽  
Surface Cooling

The Influence of Mild Hypothermia on the Pharmacokinetics and Time Course of Action of Neostigmine in Anesthetized Volunteers

2002 ◽  
Vol 97 (1) ◽  
pp. 90-95 ◽  
Author(s):  
Tom Heier ◽  
David Clough ◽  
Peter M. C. Wright ◽  
Manohar L. Sharma ◽  
Daniel I. Sessler ◽  
...  
Keyword(s):  
Time Course ◽  
Mechanical Response ◽  
Mild Hypothermia ◽  
Neuromuscular Block ◽  
Onset Time ◽  
Volume Of Distribution ◽  
Maximum Effect ◽  
Surface Cooling ◽  
Duration Of Action ◽  
Course Of Action

Background The pharmacokinetics, maximum effect, and time course of action of neostigmine were studied in seven human volunteers. Methods Each volunteer was studied twice, during both normothermia and hypothermia. Anesthesia was induced with 30 microg/kg alfentanil and 3 mg/kg propofol, and was maintained with 60-70% nitrous oxide and 0.7-0.9% isoflurane. The mechanical response of the adductor pollicis to train-of-four stimulation of the ulnar nerve was recorded, and central body temperature maintained stable at either less than 34.5 degrees C or greater than 36.5 degrees C by surface cooling or warming. Before neostigmine administration, a stable 5% twitch height was obtained by an infusion of vecuronium, and the infusion rate remained unchanged thereafter. Neostigmine, 70 microg/kg, was then infused over 2 min, and blood samples for estimation of neostigmine concentrations were collected at intervals for 240 min. Results With hypothermia, the central volume of distribution of neostigmine decreased by 38%, and onset time of maximum effect increased (4.6 vs. 5.6 min). Hypothermia did not change the clearance (696 ml/min), maximum effect, or duration of action of neostigmine. Conclusions The efficacy of neostigmine as an antagonist of vecuronium-induced neuromuscular block is not altered by mild hypothermia.

Induction and maintenance of mild hypothermia by surface cooling in non-intubated subjects

2003 ◽  
Vol 12 (5) ◽  
pp. 237-243 ◽  
Author(s):  
Richard M Zweifler ◽  
Marc E Voorhees ◽  
M.Asim Mahmood ◽  
Debra D Alday
Keyword(s):  
Mild Hypothermia ◽  
Surface Cooling

scholarly journals Surface Cooling for Rapid Induction of Mild Hypothermia After Cardiac Arrest: Design Determines Efficacy

2010 ◽  
Vol 17 (4) ◽  
pp. 360-367 ◽  
Author(s):  
Thomas Uray ◽  
Moritz Haugk ◽  
Fritz Sterz ◽  
Jasmin Arrich ◽  
Nina Richling ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Mild Hypothermia ◽  
Surface Cooling ◽  
Rapid Induction

scholarly journals Decompressive craniectomy combined with mild hypothermia in patients with large hemispheric infarction: a randomized controlled trial

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Linlin Fan ◽  
Yingying Su ◽  
Yan Zhang ◽  
Hong Ye ◽  
Weibi Chen ◽  
...  
Keyword(s):  
Decompressive Craniectomy ◽  
Neurological Outcome ◽  
Mild Hypothermia ◽  
Controlled Trial ◽  
Good Neurological Outcome ◽  
Surface Cooling ◽  
Local Cooling ◽  
Head Surface ◽  
Significant Difference ◽  
Hemispheric Infarction

Abstract Background The effect of hypothermia on large hemispheric infarction (LHI) remains controversial. Our study aimed to explore the therapeutic outcomes of decompressive craniectomy (DC) combined with hypothermia on LHI. Methods Patients were randomly divided into three groups: the DC group, the DC plus head surface cooling (DCSC) group and the DC plus endovascular hypothermia (DCEH) group. The DC group was maintained normothermia. The DCSC group received 24-h ice cap on the head for 7 days. While the DCEH group were given endovascular hypothermia (34 °C). Mortality and modified Rankin Scale (mRS) score at 6 months were evaluated. Results Thirty-four patients were included in the study. Mortality of the DC, DCSC and DCEH groups at discharge were 22.2% (2/9), 0% (0/14) and 9.1% (1/11), respectively. However, it increased to 44.4% (4/9), 21.4% (3/14) and 45.5% (5/11) at 6 months, respectively (p = 0.367). Pneumonia (8 cases) was the leading cause of death after discharge. Twelve cases (35.3%) achieved good neurological outcome (mRS 0–3) at 6 months. The proportions of good neurological outcome in the DC, DCSC and DCEH groups were 22.2% (2/9 cases), 42.9% (6/14 cases) and 36.4% (4/11), respectively. The DCSC group seemed to have higher proportion of good outcomes, but there was no significant difference between groups (p = 0.598). Among survivors, endovascular hypothermia had a higher proportion of good outcome (DC group, 2/5 cases, 40.0%; DCSC group, 6/11 cases, 54.5%; DCEH group, 4/6 cases, 66.7%; p = 0.696). The incidence of complications in the DCEH group was higher than those of the DC and DCSC groups (18.9%, 12.0%, and 12.1%, respectively; p = 0.025). Conclusions There is still no evidence to confirm that hypothermia further reduces long-term mortality and improves neurological outcomes in LHI patients with DC. However, there is a trend to benefit survivors from hypothermia. A local cooling method may be a better option for DC patients, which has little impact on systematic complications. Trial registration Decompressive Hemicraniectomy Combined Hypothermia in Malignant Middle Cerebral Artery Infarct, ChiCTR-TRC-12002698. Registered 11 Oct 2012- Retrospectively registered, URL: http://www.chictr.org.cn/showproj.aspx?proj=6854.

Abstract P136: Tracheal Temperature for Monitoring Core Temperature during Mild Hypothermia in Pigs

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Danica Krizanac ◽  
Moritz Haugk ◽  
Wolfgang Weihs ◽  
Michael Holzer ◽  
Keywan Bayegan ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Pulmonary Artery ◽  
Temperature Measurement ◽  
Core Temperature ◽  
Tracheal Tube ◽  
Mild Hypothermia ◽  
Temperature Monitoring ◽  
Surface Cooling ◽  
Significant Difference ◽  
Mean Differences

Purpose of the stud y: Early out-of-hospital induction of mild hypothermia after cardiac arrest needs an easy to use and accurate core temperature monitoring, which might be achievable with tracheal temperature measurement. The aim of the study was to evaluate which tracheal temperature site (Ttra) reflects best pulmonary artery temperature (Tpa) during the induction of mild hypothermia. Methods: Eight pigs (29 –38 kg) were anesthetized and intubated with a specially designed endotracheal tube with three temperature probes: Ttra1 was attached to the wall of the tube, 1 cm proximal to the cuff-balloon, without contact to the mucosa; Ttra2 and Ttra3 were placed on the cuff-balloon with tight contact to the mucosa, whereas Ttra3 was covered by a plastic tube to protect the mucosa. Core temperature was measured with a pulmonary artery catheter (Tpa). Pigs were cooled with a new surface cooling device (Emcoolspad®, Vienna, Austria). Data are presented as mean (±SD), and mean differences (95% CI). Results: Emcoolspad® decreased Tpa from 38.5°C to 33°C in 31±10 min, which translates into a cooling rate of 11.9±3.8°C/h. Overall mean differences of tracheal temperatures to pulmonary artery temperature (Tpa) are shown in table 1 . Ttra 1 showed the least difference to Tpa, followed by Ttra 2 and Ttra 3. There was a significant difference in temperature differences (Ttra-Tpa) related to temperature measurement site on the tracheal tube (p<0.007). Conclusions: The temperature probe proximal of the cuff (Ttra 1) reflects best pulmonary artery temperature. It seems to be an accurate surrogate for core temperature during the induction of mild hypothermia. The industry is asked to provide a tracheal tube with a temperature sensor for simple temperature monitoring during fast cooling to facilitate the implementation of mild hypothermia after cardiac arrest in the out-of-hospital setting.

scholarly journals Iceman Survived due to Cooling Device

2011 ◽  
Vol 2011 ◽  
pp. 1-2 ◽  
Author(s):  
M. Roser ◽  
F. Martens ◽  
C. Storm
Keyword(s):  
Mild Hypothermia ◽  
Feedback Mechanism ◽  
Surface Cooling ◽  
Cooling Device ◽  
Noninvasive Methods ◽  
Postresuscitation Care ◽  
Severe Hypothermia ◽  
Temperature Feedback ◽  
Life Threatening ◽  
Accidental Severe Hypothermia

Although mild hypothermia treatment is part of the standard postresuscitation care today, no standard method for treatment of accidental severe hypothermia has been yet established. Different strategies including invasive and noninvasive methods have been described in the literature. We present the case of a 75-year-old man with accidental severe hypothermia (23°C) and demonstrate that using a surface cooling device with automatic controlled temperature feedback mechanism (ArcticSun2000 Medivance, Louisville, Colorado, USA) is an effective and safe method for controlled rewarming in this life-threatening setting.

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