scholarly journals Short Duration Combined Mild Hypothermia Improves Resuscitation Outcomes in a Porcine Model of Prolonged Cardiac Arrest

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Tao Yu ◽  
Zhengfei Yang ◽  
Heng Li ◽  
Youde Ding ◽  
Zitong Huang ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Short Duration ◽  
Porcine Model ◽  
Mild Hypothermia ◽  
Survival Outcomes ◽  
Surface Cooling ◽  
Neurological Outcomes ◽  
Group A ◽  
Combined Cooling ◽  
Neuron Apoptosis

Objective.In this study, our aim was to investigate the effects of combined hypothermia with short duration maintenance on the resuscitation outcomes in a porcine model of ventricular fibrillation (VF).Methods.Fourteen porcine models were electrically induced with VF and untreated for 11 mins. All animals were successfully resuscitated manually and then randomized into two groups: combined mild hypothermia (CH group) and normothermia group (NT group). A combined hypothermia of ice cold saline infusion and surface cooling was implemented in the animals of the CH group and maintained for 4 hours. The survival outcomes and neurological function were evaluated every 24 hours until a maximum of 96 hours. Neuron apoptosis in hippocampus was analyzed.Results.There were no significant differences in baseline physiologies and primary resuscitation outcomes between both groups. Obvious improvements of cardiac output were observed in the CH group at 120, 180, and 240 mins following resuscitation. The animals demonstrated better survival at 96 hours in the CH group when compared to the NT group. In comparison with the NT group, favorable neurological functions were observed in the CH group.Conclusion.Short duration combined cooling initiated after resuscitation improves survival and neurological outcomes in a porcine model of prolonged VF.

No assisted ventilation cardiopulmonary resuscitation and 24-hour neurological outcomes in a porcine model of cardiac arrest

2010 ◽  
Vol 38 (1) ◽  
pp. 254-260 ◽  
Author(s):  
Demetris Yannopoulos ◽  
Timothy Matsuura ◽  
Scott McKnite ◽  
Noah Goodman ◽  
Ahamed Idris ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Cardiopulmonary Resuscitation ◽  
Porcine Model ◽  
Assisted Ventilation ◽  
Neurological Outcomes

scholarly journals Surface Cooling for Rapid Induction of Mild Hypothermia After Cardiac Arrest: Design Determines Efficacy

2010 ◽  
Vol 17 (4) ◽  
pp. 360-367 ◽  
Author(s):  
Thomas Uray ◽  
Moritz Haugk ◽  
Fritz Sterz ◽  
Jasmin Arrich ◽  
Nina Richling ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Mild Hypothermia ◽  
Surface Cooling ◽  
Rapid Induction

Effects of Mild Hypothermia on Cerebral Large and Small Microvessels Blood Flow in a Porcine Model of Cardiac Arrest

2017 ◽  
Vol 27 (2) ◽  
pp. 297-303 ◽  
Author(s):  
Junyuan Wu ◽  
Wei Yuan ◽  
Jiebin Li ◽  
Yongzhen Zhao ◽  
Jie Li ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cardiac Arrest ◽  
Porcine Model ◽  
Mild Hypothermia

Abstract P136: Tracheal Temperature for Monitoring Core Temperature during Mild Hypothermia in Pigs

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Danica Krizanac ◽  
Moritz Haugk ◽  
Wolfgang Weihs ◽  
Michael Holzer ◽  
Keywan Bayegan ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Pulmonary Artery ◽  
Temperature Measurement ◽  
Core Temperature ◽  
Tracheal Tube ◽  
Mild Hypothermia ◽  
Temperature Monitoring ◽  
Surface Cooling ◽  
Significant Difference ◽  
Mean Differences

Purpose of the stud y: Early out-of-hospital induction of mild hypothermia after cardiac arrest needs an easy to use and accurate core temperature monitoring, which might be achievable with tracheal temperature measurement. The aim of the study was to evaluate which tracheal temperature site (Ttra) reflects best pulmonary artery temperature (Tpa) during the induction of mild hypothermia. Methods: Eight pigs (29 –38 kg) were anesthetized and intubated with a specially designed endotracheal tube with three temperature probes: Ttra1 was attached to the wall of the tube, 1 cm proximal to the cuff-balloon, without contact to the mucosa; Ttra2 and Ttra3 were placed on the cuff-balloon with tight contact to the mucosa, whereas Ttra3 was covered by a plastic tube to protect the mucosa. Core temperature was measured with a pulmonary artery catheter (Tpa). Pigs were cooled with a new surface cooling device (Emcoolspad®, Vienna, Austria). Data are presented as mean (±SD), and mean differences (95% CI). Results: Emcoolspad® decreased Tpa from 38.5°C to 33°C in 31±10 min, which translates into a cooling rate of 11.9±3.8°C/h. Overall mean differences of tracheal temperatures to pulmonary artery temperature (Tpa) are shown in table 1 . Ttra 1 showed the least difference to Tpa, followed by Ttra 2 and Ttra 3. There was a significant difference in temperature differences (Ttra-Tpa) related to temperature measurement site on the tracheal tube (p<0.007). Conclusions: The temperature probe proximal of the cuff (Ttra 1) reflects best pulmonary artery temperature. It seems to be an accurate surrogate for core temperature during the induction of mild hypothermia. The industry is asked to provide a tracheal tube with a temperature sensor for simple temperature monitoring during fast cooling to facilitate the implementation of mild hypothermia after cardiac arrest in the out-of-hospital setting.

Abstract 305: Remote Ischemic Postconditioning Alone and Combined with Therapeutic Hypothermia Improve Neurological Outcomes After Cardiopulmonary Resuscitation in a Porcine Model

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Jiefeng Xu ◽  
Sen Ye ◽  
Zilong Li ◽  
Moli Wang ◽  
Zhengquan Wang ◽  
...  
Keyword(s):  
Therapeutic Hypothermia ◽  
Porcine Model ◽  
Limb Ischemia ◽  
Neurological Function ◽  
Cerebral Injury ◽  
Combination Group ◽  
Control Group ◽  
Protective Effects ◽  
Surface Cooling ◽  
Neurological Outcomes

Introduction: The degree of post-resuscitation cerebral injury is an important determinant on the outcomes for CA victims.We previously demonstrated remote ischemic pre- and post-conditioning equally attenuated post-CPR cerebral dysfunction in a rat model. Here we investigated the effects of remote ischemic post-conditioning (RIpostC) alone and combined with therapeutic hypothermia (TH) on the neurological outcomes after CPR. Hypothesis: RIpostC would improve post-CPR neurological function and cerebral injury, which would be enhanced by its combination with TH. Methods: Twenty-one male domestic pigs weighing 37 ± 2 kg were subjected to 10 mins of untreated VF followed by 5 mins of CPR. The animals were randomized to RIpostC, RIpostC+TH or control. Coincident with the start of CPR, RIpostC was induced by four cycles of 5 mins of limb ischemia followed by 5 mins of reperfusion. At 5 mins after resuscitation, TH was implemented by surface cooling to reach a temperature of 32-34 °C until 4 hrs post-resuscitation, followed by a rewarming rate of 1°C/h for 4 hrs. The resuscitated animals were observed for 72 hrs. Results: Six of the seven animals in each group were successfully resuscitated. Significantly better neurological function was observed in the RIpostC group than in the control group. Surprisingly the combined RIpostC and TH further improved post-CPR neurological function, which was significantly better than that in the RIpostC and control groups. There was less cerebral injury in the animals that received RIpostC alone and combined with TH; which was significantly better at 48 and 72 hrs post-resuscitation when compared to the control group. Furthermore, significantly less cerebral injury was measured at 72 hrs in the combination group than in the RIpostC group (Table). Conclusion: In a porcine model of CA, RIpostC significantly improved post-resuscitation neurological function and cerebral injury. Its combination with TH further enhanced its protective effects

scholarly journals Mild Cerebral Hypothermia during and after Cardiac Arrest Improves Neurologic Outcome in Dogs

1990 ◽  
Vol 10 (1) ◽  
pp. 57-70 ◽  
Author(s):  
Yuval Leonov ◽  
Fritz Sterz ◽  
Peter Safar ◽  
Ann Radovsky ◽  
Ken-Ichi Oku ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Treatment Group ◽  
Mild Hypothermia ◽  
Myocardial Damage ◽  
Neurologic Outcome ◽  
Control Group ◽  
Significant Group ◽  
Head Cooling ◽  
Group A ◽  
Group B

We previously found mild hypothermia (34–36°C), induced before cardiac arrest, to improve neurologic outcome. In this study we used a reproducible dog model to evaluate mild hypothermia by head cooling during arrest, continued with systemic cooling (34°C) during recirculation and for 1 h after arrest. In four groups of dogs, ventricular fibrillation (no flow) of 12.5 min at 37.5°C was reversed with cardiopulmonary bypass and defibrillation in ≤5 min, and followed by controlled ventilation to 20 h and intensive care to 96 h. In Study A we resuscitated with normotension and normal hematocrit; Control Group A-I (n = 12) was maintained normothermic, while Treatment Group A-II (n = 10) was treated with hypothermia. In Study B we resuscitated with hypertension and hemodilution. Control Group B-I (n = 12) was maintained no rmo thermic (6 of 12 were not hemodiluted), while Treatment Group B-II (n = 10) was treated with hypothermia. Best overall performance categories (OPCs) achieved between 24 and 96 h postarrest were in Group A-I: OPC 1 (normal) in 0 of 12 dogs, OPC 2 (moderate disability) in 2, OPC 3 (severe disability) in 7, and OPC 4 (coma) in 3 dogs. In Group A-II, OPC 1 was achieved in 5 of 10 dogs (p < 0.01), OPC 2 in 4 (p < 0.001), OPC 3 in 1, and OPC 4 in 0 dogs. In Group B-I, OPC 1 was achieved in 0 of 12 dogs, OPC 2 in 6, OPC 3 in 5, and OPC 4 in 1 dog. In Group B-II, OPC 1 was achieved in 6 of 10 dogs (p < 0.01), OPC 2 in 4 (p < 0.05), and OPC 3 or 4 in 0 dogs. Mean neurologic deficit and brain histopathologic damage scores showed similar significant group differences. Morphologic myocardial damage scores were the same in all four groups. We conclude that mild brain cooling during and after insult improves neurologic outcome after cardiac arrest.

Changes of Endothelin-1 and Nitric Oxide Systems in Brain Tissue During Mild Hypothermia in a Porcine Model of Cardiac Arrest

2019 ◽  
Vol 33 (1) ◽  
pp. 73-81 ◽  
Author(s):  
Junyuan Wu ◽  
Zhiwei Li ◽  
Wei Yuan ◽  
Yongzhen Zhao ◽  
Jie Li ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cardiac Arrest ◽  
Brain Tissue ◽  
Porcine Model ◽  
Mild Hypothermia ◽  
Oxide Systems ◽  
Endothelin 1

scholarly journals Out-of-hospital surface cooling with a cooling-blanket to induce mild hypothermia in humans after cardiac arrest: a feasibility trial

Critical Care ◽  
2007 ◽  
Vol 11 (Suppl 2) ◽  
pp. P327
Author(s):  
T Uray ◽  
R Malzer ◽  
A Auer ◽  
A Zajicek ◽  
F Sterz ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Mild Hypothermia ◽  
Feasibility Trial ◽  
Surface Cooling

scholarly journals Single Ventilation during Cardiopulmonary Resuscitation Results in Better Neurological Outcomes in a Porcine Model of Cardiac Arrest

2018 ◽  
Vol 59 (10) ◽  
pp. 1232
Author(s):  
Yong Won Kim ◽  
Hyung Il Kim ◽  
Sung Oh Hwang ◽  
Yoon Seop Kim ◽  
Gyo Jin An ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Cardiopulmonary Resuscitation ◽  
Porcine Model ◽  
Neurological Outcomes
Sign in / Sign up

Export Citation Format

Share Document