scholarly journals Increased procalcitonin serum levels as predictive parameter of multiple organ failure and outcome in acute pancreatitis patients

Critical Care ◽  
10.1186/cc467 ◽  
2000 ◽  
Vol 3 (S1) ◽  
Author(s):  
SMA Lobo ◽  
RF Meirelles ◽  
P Lupino ◽  
MD Pires ◽  
ML Kuga ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Serum Levels ◽  
Multiple Organ

scholarly journals A systematic review on the timing of artificial nutrition in acute pancreatitis

2008 ◽  
Vol 101 (6) ◽  
pp. 787-793 ◽  
Author(s):  
Maxim S. Petrov ◽  
Romana D. Pylypchuk ◽  
Antonina F. Uchugina
Keyword(s):  
Acute Pancreatitis ◽  
Enteral Nutrition ◽  
Parenteral Nutrition ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Infectious Complications ◽  
Multiple Organ ◽  
Artificial Nutrition ◽  
Controlled Trials ◽  
Randomised Controlled

Artificial nutrition is an inherent part of management in acute pancreatitis. However, there is no consensus regarding the optimal time of the commencement of feeding in these patients. Our aim was to compare the effect of enteral v. parenteral nutrition with regard to the time points when they were administered in the randomised controlled trials. The search was undertaken in the Cochrane Central Register of Controlled Trials, MEDLINE and Science Citation Index as well as in the proceedings of major gastroenterology meetings. The summary estimate of the effect associated with artificial nutrition was calculated using a random-effects model and presented as a risk ratio (RR) and 95 % CI. A total of eleven randomised controlled trials were included. When started within 48 h of admission, enteral nutrition, in comparison with parenteral nutrition, resulted in a statistically significant reduction in the risks of multiple organ failure (RR 0·44; 95 % CI 0·23, 0·84), pancreatic infectious complications (RR 0·46; 95 % CI 0·27, 0·77) and mortality (RR 0·46; 95 % CI 0·20, 0·99). After 48 h of admission, enteral nutrition, in comparison with parenteral nutrition, did not result in a statistically significant reduction in the risks of multiple organ failure (RR 0·73; 95 % CI 0·33, 1·63), pancreatic infectious complications (RR 0·31; 95 % CI 0·07, 1·34) and mortality (RR 0·67; 95 % CI 0·22, 2·10). Enteral nutrition is more effective than parenteral nutrition in reducing the risk of multiple organ failure, pancreatic infectious complications and mortality in patients with acute pancreatitis. The magnitude of these benefits may depend on the timing of the commencement of nutrition.

Discrepancy Between the Extent of Pancreatic Necrosis and Multiple Organ Failure Score in Severe Acute Pancreatitis

2009 ◽  
Vol 33 (11) ◽  
pp. 2427-2432 ◽  
Author(s):  
Damian J. Mole ◽  
Katie L. McClymont ◽  
Sarah Lau ◽  
Rosamund Mills ◽  
Christopher Stamp-Vincent ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Severe Acute Pancreatitis ◽  
Pancreatic Necrosis ◽  
Multiple Organ ◽  
Organ Failure Score

scholarly journals Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

2016 ◽  
Vol 22 (2) ◽  
pp. 202-209 ◽  
Author(s):  
Damian J Mole ◽  
Scott P Webster ◽  
Iain Uings ◽  
Xiaozhong Zheng ◽  
Margaret Binnie ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Multiple Organ ◽  
Rodent Models

INCREASED SERUM LEVELS OF SOLUBLE CD14 IN BURNED PATIENTS WITH MULTIPLE ORGAN FAILURE

Shock ◽  
1997 ◽  
Vol 7 (Supplement) ◽  
pp. 108
Author(s):  
Yong-Ming Yao ◽  
Yu Yan ◽  
Lian-Rong Lu ◽  
Zhi-Yong Sheng
Keyword(s):  
Multiple Organ Failure ◽  
Organ Failure ◽  
Serum Levels ◽  
Multiple Organ ◽  
Soluble Cd14

Relationship Between Plasma Cytokine Concentration and Multiple Organ Failure in Patients with Acute Pancreatitis

Pancreas ◽  
2000 ◽  
Vol 21 (2) ◽  
pp. 141-146 ◽  
Author(s):  
Masahiko Hirota ◽  
Fumiaki Nozawa ◽  
Akihiro Okabe ◽  
Muneyuki Shibata ◽  
Toru Beppu ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Multiple Organ ◽  
Cytokine Concentration ◽  
Plasma Cytokine

scholarly journals Toll-Like Receptor Ligand-Induced Liver Injury in D-Galactosamine-Sensitized Mice: Differences between TLR7/8 and TLR9 Ligands, Cytokine Patterns, and Cross-Tolerance Induction by TLR2 Ligand Pretreatment

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Reiko Seki
Keyword(s):  
Liver Injury ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Tolerance Induction ◽  
Serum Levels ◽  
Multiple Organ ◽  
Toll Like Receptor ◽  
Cross Tolerance ◽  
Cpg Dna ◽  
Tlr2 Ligand

Administration of Toll-like receptor ligands (TLRLs) is known to cause liver injury in D-galN-sensitized mice. In the present study, we aimed to complement preceding reports on the TLRL/D-galN system by analyzing comparisons among TLRLs, mouse strain dependence, effects on serum levels of cytokines, and effects of sequential administrations of different TLRLs. In a preliminary set of analyses, we first confirmed that liver failure can be induced by diverse TLRLs, including LTA and R848 in combination with D-galN. Analysis using TLR4-deficient mice excluded potential confounding effects of endogenous TLR4Ls that include those referred to as DAMPs in CpG DNA/D-galN hepatotoxicity. Subsequently, we showed that LTA pretreatment could prevent mortality in both CpG DNA/D-galN- and R848/D-galN-treated mice compared to without pretreatment. Incidentally, we observed that without the LTA pretreatment, CpG DNA/D-galN showed relatively higher liver-specific toxicity whereas R848/D-galN showed more symptoms of multiple organ failure. These findings suggest that, in D-galN-sensitized mice, different TLRLs not only show similarity in the ability to induce hepatic injury but also exhibit distinctive abilities in inducing systemic inflammation and multiple organ failure. These findings also suggest the potential usefulness of cross-tolerance induction using LTA in the prevention of organ failure in TLRL-mediated acute inflammation.

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