scholarly journals Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

2016 ◽  
Vol 22 (2) ◽  
pp. 202-209 ◽  
Author(s):  
Damian J Mole ◽  
Scott P Webster ◽  
Iain Uings ◽  
Xiaozhong Zheng ◽  
Margaret Binnie ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Multiple Organ ◽  
Rodent Models

scholarly journals A systematic review on the timing of artificial nutrition in acute pancreatitis

2008 ◽  
Vol 101 (6) ◽  
pp. 787-793 ◽  
Author(s):  
Maxim S. Petrov ◽  
Romana D. Pylypchuk ◽  
Antonina F. Uchugina
Keyword(s):  
Acute Pancreatitis ◽  
Enteral Nutrition ◽  
Parenteral Nutrition ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Infectious Complications ◽  
Multiple Organ ◽  
Artificial Nutrition ◽  
Controlled Trials ◽  
Randomised Controlled

Artificial nutrition is an inherent part of management in acute pancreatitis. However, there is no consensus regarding the optimal time of the commencement of feeding in these patients. Our aim was to compare the effect of enteral v. parenteral nutrition with regard to the time points when they were administered in the randomised controlled trials. The search was undertaken in the Cochrane Central Register of Controlled Trials, MEDLINE and Science Citation Index as well as in the proceedings of major gastroenterology meetings. The summary estimate of the effect associated with artificial nutrition was calculated using a random-effects model and presented as a risk ratio (RR) and 95 % CI. A total of eleven randomised controlled trials were included. When started within 48 h of admission, enteral nutrition, in comparison with parenteral nutrition, resulted in a statistically significant reduction in the risks of multiple organ failure (RR 0·44; 95 % CI 0·23, 0·84), pancreatic infectious complications (RR 0·46; 95 % CI 0·27, 0·77) and mortality (RR 0·46; 95 % CI 0·20, 0·99). After 48 h of admission, enteral nutrition, in comparison with parenteral nutrition, did not result in a statistically significant reduction in the risks of multiple organ failure (RR 0·73; 95 % CI 0·33, 1·63), pancreatic infectious complications (RR 0·31; 95 % CI 0·07, 1·34) and mortality (RR 0·67; 95 % CI 0·22, 2·10). Enteral nutrition is more effective than parenteral nutrition in reducing the risk of multiple organ failure, pancreatic infectious complications and mortality in patients with acute pancreatitis. The magnitude of these benefits may depend on the timing of the commencement of nutrition.

Discrepancy Between the Extent of Pancreatic Necrosis and Multiple Organ Failure Score in Severe Acute Pancreatitis

2009 ◽  
Vol 33 (11) ◽  
pp. 2427-2432 ◽  
Author(s):  
Damian J. Mole ◽  
Katie L. McClymont ◽  
Sarah Lau ◽  
Rosamund Mills ◽  
Christopher Stamp-Vincent ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Severe Acute Pancreatitis ◽  
Pancreatic Necrosis ◽  
Multiple Organ ◽  
Organ Failure Score

Relationship Between Plasma Cytokine Concentration and Multiple Organ Failure in Patients with Acute Pancreatitis

Pancreas ◽  
2000 ◽  
Vol 21 (2) ◽  
pp. 141-146 ◽  
Author(s):  
Masahiko Hirota ◽  
Fumiaki Nozawa ◽  
Akihiro Okabe ◽  
Muneyuki Shibata ◽  
Toru Beppu ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Multiple Organ ◽  
Cytokine Concentration ◽  
Plasma Cytokine

792 – Exome Sequencing to Identify Risk Factors for Multiple Organ Failure in Acute Pancreatitis

2019 ◽  
Vol 156 (6) ◽  
pp. S-167
Author(s):  
Fons F. van den Berg ◽  
Yama Issa ◽  
Marc Besselink ◽  
Frank Baas ◽  
Raoul C. Hennekam ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Pancreatitis ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Exome Sequencing ◽  
Multiple Organ
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