Prevalence of the Metabolic Syndrome in Schizophrenic Patients Receiving Second-Generation Antipsychotic Agents—A Cross-Sectional Study

2012 ◽  
Vol 25 (3) ◽  
pp. 368-373 ◽  
Author(s):  
Urmila A. Kagal ◽  
Shashikant S. Torgal ◽  
Nanasaheb M. Patil ◽  
Anil Malleshappa
Keyword(s):  
Metabolic Syndrome ◽  
Second Generation ◽  
Tertiary Care ◽  
Fasting Blood Glucose ◽  
Antipsychotic Agents ◽  
Care Hospital ◽  
Cross Sectional ◽  
The Metabolic Syndrome ◽  
Schizophrenic Patients ◽  
Second Generation Antipsychotic

Objective: The present study was taken up to assess the prevalence of the metabolic syndrome in schizophrenic patients receiving second-generation antipsychotic agents and to determine the most sensitive and specific clinical parameters used for screening of metabolic syndrome in these patients. Materials and Methods: The present study was taken up in a tertiary care hospital. Eighty patients diagnosed with schizophrenia and receiving a single second-generation antipsychotic for 3 months or more were enrolled in the study after obtaining written informed consent. Patients were screened for metabolic syndrome using American Heart Association and National, Heart, Lung and Blood Institute (AHA NHLBI)-modified National Cholesterol Education Program, Adult Treatment Panel III (NCEP ATP III) criteria. Results: Prevalence of metabolic syndrome was found to be 35%. The clinical parameter with highest sensitivity for screening of metabolic syndrome is low-serum high-density lipoprotein cholesterol with a sensitivity of 89.28%. Elevated fasting blood glucose and increased waist circumference were found to have highest and equal specificity of 90.38%. Conclusion: There is a high prevalence of the metabolic syndrome in patients with schizophrenic patients receiving second-generation antipsychotic agents. Increasing awareness of this fact among psychiatrists will help to prevent, detect, and treat this condition that is associated with considerable morbidity and mortality.

scholarly journals Association of metabolic syndrome in patients of vitiligo

2021 ◽  
Vol 7 (4) ◽  
pp. 337-340
Author(s):  
Yashdeep Jat ◽  
Krishnendra Varma ◽  
Ujjwal Kumar ◽  
Aishwarya Mahadik
Keyword(s):  
Metabolic Syndrome ◽  
Tertiary Care ◽  
Fasting Blood Glucose ◽  
Visceral Obesity ◽  
Serum Triglyceride ◽  
Clinical Feature ◽  
P Value ◽  
Serum Triglyceride Level ◽  
Care Hospital ◽  
The Metabolic Syndrome

The metabolic syndrome is the term used to describe a constellations of metabolic derangements that includes insulin resistance, hypertension, Dyslipidemia, central or visceral obesity, type 2 DM & accelerated cardiovascular disease. An oxidative imbalance is responsible for the development of both metabolic syndrome & vitiligo. In the present study we have evaluated the association of metabolic syndrome with Vitiligo.In this observational cross-sectional study we selected 40 subjects attending skin OPD with age matched 40 controls and assessed the waist circumference, blood pressure, serum triglyceride level, cholesterol and high-density cholesterol along with Fasting blood glucose level at tertiary care Hospital. A detailed history including age, gender, diabetes mellitus, hypertension, smoking and onset of vitiligo was taken. The MetS criteria were defined by National Cholesterol Education Program Adult Treatment Panel III 2005 (ATP III) guidelines.We identified metabolic syndrome in 15 subjects with vitiligo and 6 subjects without vitiligo. The P value came 0.022 which is statistically significant. Active vitiligo, segmental vitiligo and increased duration of vitiligo were determined to be independent predictors of metabolic syndrome.The risk of developing metabolic syndrome is increased in patients of vitiligo. Screening and the close follow up of the patients of vitiligo with clinical feature such as in unstable, segmental vitiligo with increased duration is necessary for the early diagnosis of the metabolic syndrome to reduce the morbidity & mortality of the patients

scholarly journals Cortisol, DHEAS, their ratio and the metabolic syndrome: evidence from the Vietnam Experience Study

2010 ◽  
Vol 162 (5) ◽  
pp. 919-923 ◽  
Author(s):  
Anna C Phillips ◽  
Douglas Carroll ◽  
Catharine R Gale ◽  
Janet M Lord ◽  
Wiebke Arlt ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Military Service ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Cross Sectional ◽  
Us Army ◽  
Telephone Interviews ◽  
The Metabolic Syndrome ◽  
Increased Risk ◽  
Vietnam Era

ObjectivesThe aim of these analyses was to examine the association of cortisol, DHEAS and the cortisol:DHEAS ratio with the metabolic syndrome (MetS) and its components.DesignThe analyses were cross-sectional.MethodsParticipants were 4255 Vietnam era US army veterans. From military service files, telephone interviews and a medical examination, occupational, socio-demographic and health data were collected. MetS was ascertained from data on body mass index; fasting blood glucose or a diagnosis of diabetes; blood pressure or a diagnosis of hypertension; high-density lipoprotein cholesterol; and triglyceride levels. Contemporary morning fasted cortisol and DHEAS concentrations were determined. The outcomes were MetS and its components. Analysis was by logistic regression, first adjusting for age and then additionally for an array of candidate confounders.ResultsCortisol, although not in the fully adjusted analysis, and DHEAS were both related to MetS. Whereas high cortisol concentrations were associated with an increased risk of MetS, high DHEAS concentrations appeared protective. By far, the strongest associations with MetS were observed for the cortisol:DHEAS ratio; the higher the ratio, the greater the risk of having MetS. The ratio was also significantly related to four of the five MetS components.ConclusionsThe cortisol:DHEAS ratio is positively associated with MetS. Prospective analyses are needed to help untangle direction of causality, but this study suggests that the cortisol:DHEAS ratio is worthy of further study in this and other health contexts.

scholarly journals Clinical and biochemical profile of obese and overweight children at a Tertiary Care Hospital.

2020 ◽  
Vol 27 (06) ◽  
pp. 1119-1123
Author(s):  
Asif Ali Khuhro ◽  
Fazal Ur Rehman ◽  
Waqas Ali ◽  
Najmi Usman ◽  
Sanam Bano Rajper
Keyword(s):  
Metabolic Syndrome ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Biochemical Profile ◽  
Overweight Children ◽  
Cross Sectional ◽  
Female Ratio ◽  
Study Participants

Objectives: Childhood and adolescent obesity is increasing especially in developing countries like Pakistan. It seem to affect most socio-economic classes as well as all ethnicities and geographies. We planned this study to analyze the clinical and biochemical profile of obese as well as overweight children at a tertiary care hospital for the existence of metabolic syndrome. Study Design: Cross sectional study. Setting: Department of Pediatrics Medicine, Children Hospital Chandka Medical College / Shaheed Mohtarma Benazir Bhutto Medical University, Larkana. Period: 1st July 2018 to 31st December 2018. Material & Methods: Children, aged 5 to 16 years, both gender, having BMI > 85th percentile regarding age and gender were enrolled. Demographic characteristics along with history, lifestyle parameters and physical examination were noted for all the study participants. Metabolic syndrome (Met S) was evaluated while overall results were presented in terms of proportions, mean and standard deviations. Results: A total of 78 cases were enrolled during the study period. There were 46 (58.9%) male and 32 (41.1%) female, with a male to female ratio of 1.4:1. Mean age amongst study participants was 10.8 years. We had 56 (71.8%) children as overweight whereas 22 (28.2%) obese. Acanthosis nigricans was the most common entity seen in 55 (70.1%) children during clinical examination. Metabolic syndrome was found to be present in 31 (39.7%) participants. Conclusion: Met S is not only limited to obese children as it can also affect children who are overweight.

scholarly journals PHARMACOLOGY IN SCHIZOPHRENIA

2019 ◽  
Vol 3 (10) ◽  
Author(s):  
Rameshwar S Manhas ◽  
Gaurav S Manhas ◽  
Rukhsana Akhter ◽  
Jagdish R Thappa ◽  
Angli Manhas
Keyword(s):  
Atypical Antipsychotic ◽  
Antipsychotic Drugs ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Abnormal Behavior ◽  
Care Hospital ◽  
Cross Sectional ◽  
Atypical Antipsychotic Drugs ◽  
Schizophrenic Patients ◽  
Number Combination

Background: Schizophrenia is a chronic debilitating major psychiatric illness which is characterized by a decreased ability to understand reality, strange speech and abnormal behavior. Aims: To find out pharmacological patterns in schizophrenic patients. Materials & Methods: The present observational cross-sectional study involved prescription of 150 schizophrenic patients and was conducted in the outpatient department (OPD) of tertiary care hospital, Jammu over a period of two months. Data like name, number, combination of drugs etc of psychotropic medications were collected Results: Average number of drugs per prescription was 2.26. Among prescribed antipsychotics, 87.9% were atypical antipsychotic drugs. Single antipsychotic was used in 57.3% patients whereas combination of antipsychotics were used in 42.7% patients. Olanzapine was the most commonly used antipsychotic drug and was prescribed in 72.7% patients. Benzodiazepines were the most commonly used comedications and were prescribed in 62% patients. Conclusion: From present study, it has been concluded that atypical antipsychotic drugs were the most frequently prescribed among schizophrenic patients. The most common medication to be used was olanzapine whereas the most common comedications used along with antipsychotics were benzodiazepines. Keywords: Antipsychotics, Olanzapine, Schizophrenia.

scholarly journals EPICARDIALADIPOSE TISSUE THICKNESS IN PATIENTS WITH METABOLIC SYNDROME AND ITS ASSOCIATION WITH CARDIOVASCULAR RISK FACTORS.

2020 ◽  
pp. 26-28
Author(s):  
Jayanta Saha ◽  
Kuntal Bhattacharyya ◽  
Shravan Kumar ◽  
Debarshi Jana
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Cardiovascular Risk ◽  
Observational Study ◽  
Sample Size ◽  
Cardiovascular Risk Factors ◽  
Tertiary Care ◽  
International Diabetes Federation ◽  
Care Hospital ◽  
Cross Sectional

INTRODUCTION Metabolic syndrome is a constellation of several cardiovascular risk factors, and is defined by the National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III criteria (2001) or the International Diabetes Federation (IDF) criteria (2005). 1, 2The prevalence of metabolic syndrome varies between 24.6 - 41% in different parts of Indian subcontinent and based on different criteria for metabolic syndrome. OBJECTIVES To assess epicardial adipose tissue (EAT) thickness by echocardiography in patients with metabolic syndrome, and find out if there is any association between EAT thickness and different cardiovascular risk factors. MATERIALS AND METHODS This cross-sectional observational study was conducted in a tertiary care hospital in India among patients attending the Medicine and Cardiology out-patient department (OPD) during the study period of six months from May 2018 to October 2018. Patients satisfying the diagnostic criteria of metabolic syndrome as per the IDF criteria (2005) were included in the study, as there are separate cut off points for waist circumference for South Asian population. Design: Cross-sectional observational study. Setting: Single centre study in a tertiary care teaching hospital. Participants: Initially 450 patients with metabolic syndrome as per International Diabetes Federation (IDF) criteria (2005) were screened. Patients having age above 65 years, deranged liver/renal function, ischemic heart disease, heart failure, malignancy, pregnancy, ascitis, poor echo window, history of endocrine disorders like Cushing Syndrome, glucocorticoid use, having any acute illness and those not giving consent were excluded. Final sample size was 397. For defining the normal EAT thickness in this geographic region, 50 age and gender matched healthy volunteers without any conventional cardiovascular risk factors (except age in some cases) acted as controls. Study period was six months. RESULT The mean value of EAT thickness in the control group was 2.97 (± 0.86) mm, hence the upper reference limit of EAT thickness in this study was taken as more than mean + 2SD, i.e. 4.69mm. Mean EAT thickness in patients suffering from metabolic syndrome was 5.48 ± 0.83 mm, which was significantly increased compared to controls. Taking 4.69mm as cut off, it was seen that 311 (78.34%) patients had increased EAT thickness >4.69mm. CONCLUSION Further studies with larger sample size and longitudinal design are required to establish the ability of EAT thickness to predict cardiovascular risk.

scholarly journals A study of metabolic syndrome in patients of HIV on ART in India

2021 ◽  
Author(s):  
V K Sashindran ◽  
Anchit Raj Singh
Keyword(s):  
Metabolic Syndrome ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Noncommunicable Diseases ◽  
Care Hospital ◽  
Cross Sectional ◽  
High Prevalence ◽  
Hiv Morbidity ◽  
The Impact

AbstractMetabolic syndrome is a risk factor for cardiovascular disease. With improvement in therapy for HIV, morbidity related to metabolic syndrome becomes a focus of interest. Change in nutritional status and introduction of newer regimens of ART are changing the impact of metabolic syndrome on patients of HIV. Few studies in recent times from developing countries have addressed this question. This is a cross sectional study to study the prevalence of Metabolic Syndrome in patients of HIV on ART from clinics in a tertiary care hospital in India. Data from 1208 patients of HIV on ART was analyzed and metabolic syndrome was seen in 257(21.3%) patients.The high prevalence of metabolic syndrome in patients of HIV in India found in this study gives an insight on the morbidity of noncommunicable diseases in patients with HIV in India in recent times.

scholarly journals Prevalence of different components of the metabolic syndrome in type 2 diabetics attending tertiary care hospital in Himalayan region

2017 ◽  
Vol 5 (12) ◽  
pp. 5232
Author(s):  
Vikram Singh ◽  
Mridu Singh ◽  
Anil Joshi ◽  
Chitra Joshi
Keyword(s):  
Metabolic Syndrome ◽  
Tertiary Care ◽  
International Diabetes Federation ◽  
Diabetic Patients ◽  
Care Hospital ◽  
The Metabolic Syndrome ◽  
Type 2 Diabetics ◽  
Hilly Region ◽  
Prevalence Of Obesity

Background: There are enormous studies on various aspect of Diabetes and Metabolic syndrome, majority of studies are on urban population, few in rural area but very few for the population living in far flung hilly region of Himalaya. The aim was to find the prevalence of different components of metabolic syndrome in Type 2 diabetics living in the hills of Himalaya and to find correlation with obesity.Methods: All the Type 2 Diabetic patients age 35 years and above attending the inpatients and out patient’s department of V. C. S. G. G. M. C and RI Srinagar, Uttarakhand from October 2012 to March 2013 were enrolled and were evaluated for metabolic syndrome by IDF (International Diabetes Federation) criteria.Results: 128 diabetics were enrolled (76 males and 52 females), the prevalence of obesity in patients of type 2 diabetics was 45.3%. There was poor correlation between obesity and type 2 diabetes (correlation coefficient 0.08) The prevalence of metabolic syndrome was 40.6 % and high percentage (62%) had all five components of the syndrome.Conclusions: The prevalence of obesity and Metabolic syndrome is relatively lower in Type 2 Diabetics of Shivalik range of Himalaya (Uttarakhand).

scholarly journals Age and Gender Differences of Metabolic Factors among the Essential Hypertension Patients at a Tertiary Care Hospital in Dhaka

2016 ◽  
Vol 12 (2) ◽  
pp. 34-38
Author(s):  
Md. Akhtaruzzaman ◽  
Md. Nazibur Rahman Khandaker ◽  
Fatema Akhter Banu ◽  
Gobinda Chandra Saha ◽  
Md. Abdullah Yusuf ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Essential Hypertension ◽  
Waist Circumference ◽  
Tertiary Care ◽  
Care Hospital ◽  
Metabolic Factors ◽  
College Hospital ◽  
Hypertensive Patients ◽  
The Metabolic Syndrome ◽  
Increased Risk

Background: Metabolic syndrome is a risk factor for cardiovascular disease. Objectives: The purpose of the present study was to see the association of metabolic syndrome with essential hypertension. Methodology: This cross sectional study was carried out in the OPD of the Department of Cardiology at Shaheed Suhrawardy Medical college Hospital, Dhaka from January 2008 to December 2010. All the All the Metabolic syndrome was defined as abnormal fasting serum level of glucose (? 110 mg/dl or 6.1 mmol/L) with abdominal obesity (waist circumference > 102 cm in men and > 88cm in women), triglycerides (? 150mg/dl), High density lipoprotein cholesterol (< 40 mg/dl in men and < 50 mg/dl in women) and hypertension. Results: . A total of 322 patients were enrolled Among hypertensive patients 31.8% had hyperglycemia, 37.9% had high waist circumference, 69.8% had low HDL cholesterol and 54.3% high triglycerides. As per definition of NCEP-ATP-III, metabolic syndrome had been detected in 17% of male, 37% of female and 27% of total population. Conclusion: Metabolic factors are a common association in hypertensive cases. These patients are at increased risk of coronary and cerebro-vascular disease and require more vigorous prevention. Furthermore in all hypertensive patients metabolic screening is recommended.Journal of Science Foundation 2014;12(2): 34-38DOI: http://dx.doi.org/10.3329/jsf.v12i2.27736

scholarly journals EVALUATION OF METABOLIC SYNDROME IN HEALTHY YEMENI POPULATIONS

2020 ◽  
Author(s):  
Gamil Alrubaiee ◽  
Ali Alyahawi
Keyword(s):  
Metabolic Syndrome ◽  
Peer Review ◽  
Fasting Blood Glucose ◽  
Morbidity And Mortality ◽  
Cross Sectional ◽  
The Metabolic Syndrome ◽  
Total Prevalence ◽  
Cardiovascular Morbidity And Mortality ◽  
Significant Difference ◽  
E Mail

The metabolic syndrome is characterized by several cardiovascular risk factors and is associated with an increased incidence of diabetes, cardiovascular events and mortality. The prevalence of metabolic syndrome is increasing in epidemic proportions worldwide. The present study aimed to investigate the prevalence of MS and its components in healthy populations in Sana'a, Yemen. This study was a cross-sectional study conducted from February 2019 to April 2019. A total of 120 healthy populations (>=40 years old) were selected. The study protocol was approved by the institutional ethical committee and informed consent was obtained from all the enrolled study patients for their inclusion in the screening and participation in the research. In the present study, the diagnosis of metabolic syndrome based on the American Heart Association/National Heart, Lung, and Blood Institute(AHA/NHL BI) and to a joint statement from several large organizations. In the current study, the presence of more than or equal to any three of the above mentioned factors is required for the diagnosis of metabolic syndrome. The total prevalence of MS among the study subjects was 40.0% (P< 0.001) and 62.5%of them were within 40-49 years old. In the present study, there was not statically significant difference between the khat chewing and the metabolic syndrome. According the distribution of metabolic syndrome criteria among subjects with metabolic syndrome, the prevalence of fasting blood glucose (FBG) was the highest (85%). The prevalence of metabolic syndrome among healthy Yemeni populations was very high and it is associated with increased morbidity and mortality.  This emphasizes the need for more attention to investigate this condition to decreasing the prevalence of cardiovascular morbidity and mortality in these subjects. Peer Review History: UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 8.0/10 Reviewer(s) detail: Name: Dr. Hassan A.H. Al-Shamahy Affiliation: Sana'a University, Yemen E-mail: [email protected]   Name: Dr. Muhammad Shahzad Aslam Affiliation: Universiti Malaysia Perlis, Malaysia E-mail: [email protected] Comments of reviewer(s): Similar Articles: PREVALENCE OF HEPATITIS G VIRUS AMONG PATIENTS WITH CHRONIC LIVER DISEASE AND HEALTHY INDIVIDUALS, SANA'A CITY-YEMEN  

The association between milk consumption and the metabolic syndrome: a cross-sectional study of the residents of Suzhou, China and a meta-analysis

2020 ◽  
Vol 123 (9) ◽  
pp. 1013-1023 ◽  
Author(s):  
Khemayanto Hidayat ◽  
Lu-Gang Yu ◽  
Jin-Rong Yang ◽  
Xue-Ying Zhang ◽  
Hui Zhou ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Observational Studies ◽  
Fasting Blood Glucose ◽  
Final Analysis ◽  
Cross Sectional Study ◽  
Milk Consumption ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Metabolic Syndrome ◽  
Significant Difference

AbstractThe association between milk consumption and the metabolic syndrome remains inconclusive, and data from Chinese populations are scarce. We conducted a cross-sectional study to investigate the association between milk consumption and the metabolic syndrome and its components among the residents of Suzhou Industrial Park, Suzhou, China. A total of 5149 participants were included in the final analysis. A logistic regression model was applied to estimate the OR and 95 % CI for the prevalence of the metabolic syndrome and its components according to milk consumption. In addition, the results of our study were further meta-analysed with other published observational studies to quantify the association between the highest v. lowest categories of milk consumption and the metabolic syndrome and its components. There was no significant difference in the odds of having the metabolic syndrome between milk consumers and non-milk consumers (OR 0·86, 95 % CI 0·73, 1·01). However, milk consumers had lower odds of having elevated waist circumference (OR 0·78, 95 % CI 0·67, 0·92), elevated TAG (OR 0·83, 95 % CI 0·70, 0·99) and elevated blood pressure (OR 0·85, 95 % CI 0·73, 0·99). When the results were pooled together with other published studies, higher milk consumption was inversely associated with the risk of the metabolic syndrome (relative risk 0·80, 95 % CI 0·72, 0·88) and its components (except elevated fasting blood glucose); however, these results should be treated with caution as high heterogeneity was observed. In summary, the currently available evidence from observational studies suggests that higher milk consumption may be inversely associated with the metabolic syndrome.

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