PHARMACOLOGY IN SCHIZOPHRENIA

Background: Schizophrenia is a chronic debilitating major psychiatric illness which is characterized by a decreased ability to understand reality, strange speech and abnormal behavior. Aims: To find out pharmacological patterns in schizophrenic patients. Materials & Methods: The present observational cross-sectional study involved prescription of 150 schizophrenic patients and was conducted in the outpatient department (OPD) of tertiary care hospital, Jammu over a period of two months. Data like name, number, combination of drugs etc of psychotropic medications were collected Results: Average number of drugs per prescription was 2.26. Among prescribed antipsychotics, 87.9% were atypical antipsychotic drugs. Single antipsychotic was used in 57.3% patients whereas combination of antipsychotics were used in 42.7% patients. Olanzapine was the most commonly used antipsychotic drug and was prescribed in 72.7% patients. Benzodiazepines were the most commonly used comedications and were prescribed in 62% patients. Conclusion: From present study, it has been concluded that atypical antipsychotic drugs were the most frequently prescribed among schizophrenic patients. The most common medication to be used was olanzapine whereas the most common comedications used along with antipsychotics were benzodiazepines. Keywords: Antipsychotics, Olanzapine, Schizophrenia.

Performance of Fractional-Slot Winding PM Machines due to Un-even Coil Turns and Asymmetric Design of Stator Teeth

PM machines in which slot number and pole number combination differs by one have to be configured with asymmetric winding pattern in order to maximize it back-emf performance. However, this asymmetric winding configuration inherently results an unwanted Unabalanced Magnetic Force (UMF). Investigations of electromagnetic performance of fractional-slot asymmetric winding PM machines using 2-D Finite-Element Analysis are presented. The investigations are mainly driven by the effort of minimizing the UMF. By employing techniques such as non-uniform number of coil turns in every tooth and asymmetric design of stator tooth, the UMF are expected can be minimized. The investigations show that the radial component of UMF has greater effect than the tangential component on the UMF itself. In all proposed techniques, a slight reduction of machine torque performance is inevitable.