Effect of Tanshinone IIA in an In Vitro Model of Graves' Orbitopathy

2014 ◽  
Vol 55 (9) ◽  
pp. 5900 ◽  
Author(s):  
Soolienah Rhiu ◽  
Min Kyung Chae ◽  
Eun Jig Lee ◽  
Jong Bok Lee ◽  
Jin Sook Yoon
Keyword(s):  
In Vitro Model ◽  
Tanshinone Iia ◽  
Graves Orbitopathy ◽  
Vitro Model

scholarly journals Therapeutic Effect of Protocatechuic Aldehyde in an In Vitro Model of Graves' Orbitopathy

2016 ◽  
Vol 57 (10) ◽  
pp. 4055 ◽  
Author(s):  
Jung Woo Byun ◽  
Sena Hwang ◽  
Chan Woo Kang ◽  
Jin Hee Kim ◽  
Min Kyung Chae ◽  
...  
Keyword(s):  
Therapeutic Effect ◽  
In Vitro Model ◽  
Protocatechuic Aldehyde ◽  
Graves Orbitopathy ◽  
Vitro Model

scholarly journals Role of miR-146a in the Regulation of Inflammation in an In Vitro Model of Graves' Orbitopathy

2016 ◽  
Vol 57 (10) ◽  
pp. 4027 ◽  
Author(s):  
Sun Young Jang ◽  
Min Kyung Chae ◽  
Joon H. Lee ◽  
Eun Jig Lee ◽  
Jin Sook Yoon
Keyword(s):  
In Vitro Model ◽  
Graves Orbitopathy ◽  
Vitro Model

scholarly journals Protein tyrosine phosphatase 1B as a therapeutic target for Graves’ orbitopathy in an in vitro model

PLoS ONE ◽  
2020 ◽  
Vol 15 (8) ◽  
pp. e0237015 ◽  
Author(s):  
Hyeong Ju Byeon ◽  
Ji-Young Kim ◽  
JaeSang Ko ◽  
Eun Jig Lee ◽  
Kikkawa Don ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Therapeutic Target ◽  
In Vitro Model ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Graves Orbitopathy ◽  
Vitro Model

scholarly journals Independent Adipogenic and Contractile Properties of Fibroblasts in Graves’ Orbitopathy: An In Vitro Model for the Evaluation of Treatments

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e95586 ◽  
Author(s):  
He Li ◽  
Caroline Fitchett ◽  
Katarzyna Kozdon ◽  
Hari Jayaram ◽  
Geoffrey E. Rose ◽  
...  
Keyword(s):  
In Vitro Model ◽  
Contractile Properties ◽  
Graves Orbitopathy ◽  
Vitro Model

An in vitro model for investigation of vitamin A effects on wound healing

2021 ◽  
pp. 1-6
Author(s):  
Hoda Keshmiri Neghab ◽  
Mohammad Hasan Soheilifar ◽  
Gholamreza Esmaeeli Djavid
Keyword(s):  
Wound Healing ◽  
Endothelial Cell ◽  
Vitamin A ◽  
In Vitro Model ◽  
Cellular Proliferation ◽  
Endothelial Cell Migration ◽  
Normal Fibroblast ◽  
Anti Inflammatory ◽  
Vitro Model

Abstract. Wound healing consists of a series of highly orderly overlapping processes characterized by hemostasis, inflammation, proliferation, and remodeling. Prolongation or interruption in each phase can lead to delayed wound healing or a non-healing chronic wound. Vitamin A is a crucial nutrient that is most beneficial for the health of the skin. The present study was undertaken to determine the effect of vitamin A on regeneration, angiogenesis, and inflammation characteristics in an in vitro model system during wound healing. For this purpose, mouse skin normal fibroblast (L929), human umbilical vein endothelial cell (HUVEC), and monocyte/macrophage-like cell line (RAW 264.7) were considered to evaluate proliferation, angiogenesis, and anti-inflammatory responses, respectively. Vitamin A (0.1–5 μM) increased cellular proliferation of L929 and HUVEC (p < 0.05). Similarly, it stimulated angiogenesis by promoting endothelial cell migration up to approximately 4 fold and interestingly tube formation up to 8.5 fold (p < 0.01). Furthermore, vitamin A treatment was shown to decrease the level of nitric oxide production in a dose-dependent effect (p < 0.05), exhibiting the anti-inflammatory property of vitamin A in accelerating wound healing. These results may reveal the therapeutic potential of vitamin A in diabetic wound healing by stimulating regeneration, angiogenesis, and anti-inflammation responses.

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