Disulfiram exerts antiadipogenic, anti-inflammatory, and antifibrotic therapeutic effects in an in vitro model of Graves’ orbitopathy

Thyroid ◽  
2021 ◽  
Author(s):  
Xing Wang ◽  
Shenglan Yang ◽  
Huijing Ye ◽  
Jingqiao Chen ◽  
Lu Shi ◽  
...  
Keyword(s):  
In Vitro Model ◽  
Therapeutic Effects ◽  
Graves Orbitopathy ◽  
Anti Inflammatory ◽  
Vitro Model

An in vitro model for investigation of vitamin A effects on wound healing

2021 ◽  
pp. 1-6
Author(s):  
Hoda Keshmiri Neghab ◽  
Mohammad Hasan Soheilifar ◽  
Gholamreza Esmaeeli Djavid
Keyword(s):  
Wound Healing ◽  
Endothelial Cell ◽  
Vitamin A ◽  
In Vitro Model ◽  
Cellular Proliferation ◽  
Endothelial Cell Migration ◽  
Normal Fibroblast ◽  
Anti Inflammatory ◽  
Vitro Model

Abstract. Wound healing consists of a series of highly orderly overlapping processes characterized by hemostasis, inflammation, proliferation, and remodeling. Prolongation or interruption in each phase can lead to delayed wound healing or a non-healing chronic wound. Vitamin A is a crucial nutrient that is most beneficial for the health of the skin. The present study was undertaken to determine the effect of vitamin A on regeneration, angiogenesis, and inflammation characteristics in an in vitro model system during wound healing. For this purpose, mouse skin normal fibroblast (L929), human umbilical vein endothelial cell (HUVEC), and monocyte/macrophage-like cell line (RAW 264.7) were considered to evaluate proliferation, angiogenesis, and anti-inflammatory responses, respectively. Vitamin A (0.1–5 μM) increased cellular proliferation of L929 and HUVEC (p < 0.05). Similarly, it stimulated angiogenesis by promoting endothelial cell migration up to approximately 4 fold and interestingly tube formation up to 8.5 fold (p < 0.01). Furthermore, vitamin A treatment was shown to decrease the level of nitric oxide production in a dose-dependent effect (p < 0.05), exhibiting the anti-inflammatory property of vitamin A in accelerating wound healing. These results may reveal the therapeutic potential of vitamin A in diabetic wound healing by stimulating regeneration, angiogenesis, and anti-inflammation responses.

Effect of Tanshinone IIA in an In Vitro Model of Graves' Orbitopathy

2014 ◽  
Vol 55 (9) ◽  
pp. 5900 ◽  
Author(s):  
Soolienah Rhiu ◽  
Min Kyung Chae ◽  
Eun Jig Lee ◽  
Jong Bok Lee ◽  
Jin Sook Yoon
Keyword(s):  
In Vitro Model ◽  
Tanshinone Iia ◽  
Graves Orbitopathy ◽  
Vitro Model

scholarly journals Therapeutic Effect of Protocatechuic Aldehyde in an In Vitro Model of Graves' Orbitopathy

2016 ◽  
Vol 57 (10) ◽  
pp. 4055 ◽  
Author(s):  
Jung Woo Byun ◽  
Sena Hwang ◽  
Chan Woo Kang ◽  
Jin Hee Kim ◽  
Min Kyung Chae ◽  
...  
Keyword(s):  
Therapeutic Effect ◽  
In Vitro Model ◽  
Protocatechuic Aldehyde ◽  
Graves Orbitopathy ◽  
Vitro Model

Anti-inflammatory effects of dietary phenolic compounds in an in vitro model of inflamed human intestinal epithelium

2010 ◽  
Vol 188 (3) ◽  
pp. 659-667 ◽  
Author(s):  
Thérèse Sergent ◽  
Neil Piront ◽  
Julie Meurice ◽  
Olivier Toussaint ◽  
Yves-Jacques Schneider
Keyword(s):  
Phenolic Compounds ◽  
Intestinal Epithelium ◽  
In Vitro Model ◽  
Anti Inflammatory ◽  
Vitro Model ◽  
Human Intestinal Epithelium

scholarly journals Role of miR-146a in the Regulation of Inflammation in an In Vitro Model of Graves' Orbitopathy

2016 ◽  
Vol 57 (10) ◽  
pp. 4027 ◽  
Author(s):  
Sun Young Jang ◽  
Min Kyung Chae ◽  
Joon H. Lee ◽  
Eun Jig Lee ◽  
Jin Sook Yoon
Keyword(s):  
In Vitro Model ◽  
Graves Orbitopathy ◽  
Vitro Model
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