scholarly journals Inhibitory Effect of Idelalisib, a Selective Phosphatidylinositol 3-Kinase δ Inhibitor, on Adipogenesis in an In Vitro Model of Graves' Orbitopathy

2018 ◽  
Vol 59 (11) ◽  
pp. 4477 ◽  
Author(s):  
JaeSang Ko ◽  
Ji-Young Kim ◽  
Eun Jig Lee ◽  
Jin Sook Yoon
Keyword(s):  
In Vitro Model ◽  
Inhibitory Effect ◽  
Phosphatidylinositol 3 Kinase ◽  
Graves Orbitopathy ◽  
Vitro Model ◽  
Phosphatidylinositol 3

Effect of Tanshinone IIA in an In Vitro Model of Graves' Orbitopathy

2014 ◽  
Vol 55 (9) ◽  
pp. 5900 ◽  
Author(s):  
Soolienah Rhiu ◽  
Min Kyung Chae ◽  
Eun Jig Lee ◽  
Jong Bok Lee ◽  
Jin Sook Yoon
Keyword(s):  
In Vitro Model ◽  
Tanshinone Iia ◽  
Graves Orbitopathy ◽  
Vitro Model

scholarly journals Therapeutic Effect of Protocatechuic Aldehyde in an In Vitro Model of Graves' Orbitopathy

2016 ◽  
Vol 57 (10) ◽  
pp. 4055 ◽  
Author(s):  
Jung Woo Byun ◽  
Sena Hwang ◽  
Chan Woo Kang ◽  
Jin Hee Kim ◽  
Min Kyung Chae ◽  
...  
Keyword(s):  
Therapeutic Effect ◽  
In Vitro Model ◽  
Protocatechuic Aldehyde ◽  
Graves Orbitopathy ◽  
Vitro Model

scholarly journals Comparative Bactericidal Activities of Ciprofloxacin, Clinafloxacin, Grepafloxacin, Levofloxacin, Moxifloxacin, and Trovafloxacin against Streptococcus pneumoniae in a Dynamic In Vitro Model

2001 ◽  
Vol 45 (3) ◽  
pp. 673-678 ◽  
Author(s):  
Michael E. Klepser ◽  
Erika J. Ernst ◽  
C. Rosemarie Petzold ◽  
Paul Rhomberg ◽  
Gary V. Doern
Keyword(s):  
Streptococcus Pneumoniae ◽  
In Vitro Model ◽  
Rank Order ◽  
Active Agent ◽  
Inhibitory Effect ◽  
Pharmacokinetic Data ◽  
Time Curve ◽  
Bactericidal Activities ◽  
Vitro Model

ABSTRACT Several new quinolones that exhibit enhanced in vitro activity against Streptococcus pneumoniae have been developed. Using a dynamic in vitro model, we generated time-kill data for ciprofloxacin, clinafloxacin, grepafloxacin, levofloxacin, moxifloxacin, and trovafloxacin against three isolates of quinolone-susceptible S. pneumoniae. Three pharmacokinetic profiles were simulated for each of the study agents (0.1, 1, and 10 times the area under the concentration-time curve [AUC]). Target 24-h AUCs were based upon human pharmacokinetic data resulting from the maximal daily doses of each agent. Ciprofloxacin was the least active agent against all three isolates. With regimens that simulated the human 24-h AUC, ciprofloxacin resulted in an initial, modest decline in the numbers of CFU per milliliter; however, by 48 h the numbers of CFU per milliliter returned to or exceeded the starting inoculum. At the AUC, levofloxacin resulted in variable bacteriostatic and bactericidal activities against the isolates. The remaining agents yielded bactericidal (99.9% reduction) activity by 48 h with regimens that simulated the AUC. At 0.1 time the AUC ciprofloxacin and levofloxacin produced no inhibitory effect, grepafloxacin exhibited bacteriostatic activity, trovafloxacin had mixed static and cidal activities, and clinafloxacin and moxifloxacin caused significant reductions in the numbers of CFU per milliliter by 48 h. All six agents produced cidal activity at 10 times the AUC. In this dynamic in vitro model of infection, the quinolones demonstrated various degrees of activity against S. pneumoniae. The rank order of activity, with respect to bactericidal effect, was ciprofloxacin (least active) ≪ levofloxacin < grepafloxacin, trovafloxacin < clinafloxacin and moxifloxacin (most active). The rank order of the agents with respect to the selection of resistance was ciprofloxacin (most likely) > grepafloxacin, moxifloxacin, and trovafloxacin > levofloxacin > clinafloxacin.

scholarly journals Role of miR-146a in the Regulation of Inflammation in an In Vitro Model of Graves' Orbitopathy

2016 ◽  
Vol 57 (10) ◽  
pp. 4027 ◽  
Author(s):  
Sun Young Jang ◽  
Min Kyung Chae ◽  
Joon H. Lee ◽  
Eun Jig Lee ◽  
Jin Sook Yoon
Keyword(s):  
In Vitro Model ◽  
Graves Orbitopathy ◽  
Vitro Model

scholarly journals Protein tyrosine phosphatase 1B as a therapeutic target for Graves’ orbitopathy in an in vitro model

PLoS ONE ◽  
2020 ◽  
Vol 15 (8) ◽  
pp. e0237015 ◽  
Author(s):  
Hyeong Ju Byeon ◽  
Ji-Young Kim ◽  
JaeSang Ko ◽  
Eun Jig Lee ◽  
Kikkawa Don ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Therapeutic Target ◽  
In Vitro Model ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Graves Orbitopathy ◽  
Vitro Model

scholarly journals α-Glucosidase Inhibitory and Antiradical Properties of Acacia macrostachya

2020 ◽  
Vol 2 (5) ◽  
Author(s):  
Hamidou Têeda Ganamé ◽  
Yssouf Karanga ◽  
Ousmane Ilboudo ◽  
Wende-Konté Hazael Conania Nikiema ◽  
Richard Wamtinga Sawadogo ◽  
...  
Keyword(s):  
In Vitro Model ◽  
Antiradical Activity ◽  
Methanolic Extract ◽  
Inhibitory Effect ◽  
Traditional Use ◽  
Methanol Extracts ◽  
Antiradical Properties ◽  
Ic50 Values ◽  
Vitro Model

In this work, the anti-diabetic activity of three extracts of Acacia macrostachya was investigated by following the inhibitory effect of these extracts on -glucosidase using the in vitro model. The antiradical activity of these extracts was also determined. Methanol extracts of root and stem barks showed a very significant inhibitory effect against the enzyme activity of -glucosidase with IC50 2.487 ± 0.441 µg/mL and 1.650 ± 0.229 µg/mL respectively. For antiradical activity, the same extracts presented the highest scavenging of the radical DPPH● with IC50 values of 9.307 ± 0.262 µg/mL and 5.242 ± 0.068 µg/mL respectively. With the cationic radical ABTS●+, IC50 varied from 45.049 ± 0.730 µg/mL for methanolic root barks extract to 14.136 ± 0.161 µg/mL for methanolic extract from stem barks. Thus, the methanol extracts of the root and stem barks of Acacia macrostachya possess compounds with very interesting anti-diabetic and antiradical properties and could justify its traditional use.

scholarly journals Independent Adipogenic and Contractile Properties of Fibroblasts in Graves’ Orbitopathy: An In Vitro Model for the Evaluation of Treatments

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e95586 ◽  
Author(s):  
He Li ◽  
Caroline Fitchett ◽  
Katarzyna Kozdon ◽  
Hari Jayaram ◽  
Geoffrey E. Rose ◽  
...  
Keyword(s):  
In Vitro Model ◽  
Contractile Properties ◽  
Graves Orbitopathy ◽  
Vitro Model
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