Whole-Body Bioluminescent Imaging of Human Uveal Melanoma in a New Mouse Model of Local Tumor Growth and Metastasis

2005 ◽  
Vol 46 (5) ◽  
pp. 1581 ◽  
Author(s):  
Irene C. Notting ◽  
Jeroen T. Buijs ◽  
Ivo Que ◽  
Ratna E. Mintardjo ◽  
Geertje van der Horst ◽  
...  
Keyword(s):  
Mouse Model ◽  
Tumor Growth ◽  
Uveal Melanoma ◽  
Whole Body ◽  
Bioluminescent Imaging ◽  
Local Tumor ◽  
Tumor Growth And Metastasis ◽  
Local Tumor Growth

scholarly journals Establishment of an Endoscopy-Guided Minimally Invasive Orthotopic Mouse Model of Colorectal Cancer

Cancers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 3007
Author(s):  
Chen Chen ◽  
Jens Neumann ◽  
Florian Kühn ◽  
Serene M. L. Lee ◽  
Moritz Drefs ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mouse Model ◽  
Minimally Invasive ◽  
Tumor Growth ◽  
Hepatic Metastases ◽  
Specific Cell ◽  
Local Tumor ◽  
Orthotopic Mouse Model ◽  
Endoscopic Score ◽  
Local Tumor Growth

Open orthotopic mouse models of colorectal cancer have disadvantages such as the requirement for advanced surgical skills or the trauma caused by laparotomy. To overcome these drawbacks, this study aimed to evaluate the establishment of a minimally invasive model using murine colonoscopy. CT26 and MC38 CRC cells of different concentrations were injected into BALB/C and C57BL/6J mice, respectively. Follow-up endoscopies were performed to assign an endoscopic score to tumor growth. Gross autopsy, histologic and immuno-histochemical evaluation, and immune scoring were performed. To describe the learning curve of the procedures, a performance score was given. Local tumor growth with colorectal wall infiltration, luminal ulceration, the presence of tumor-infiltrating lymphocytes, lympho-vascular invasion, and early spontaneous lymph node, peritoneal, and hepatic metastases were observed. The tumors showed cytoplasmic immuno-staining for CK20. Compared to the MC38/C57BL/6J model, tumorigenicity and immunogenicity of the CT26/BALB/C model were higher. Tumor volume correlated with the endoscopic score. This endoscopy-guided orthotopic mouse model is easy to learn and quick to establish. It features early metastasis and enables the study of interactions with the immune system. When specific cell concentrations and cell lines are applied, controlled local tumor growth and metastasis can be achieved within short observation periods.

scholarly journals A Mechanism-Based Combination Therapy Reduces Local Tumor Growth and Metastasis in an Orthotopic Model of Prostate Cancer

2006 ◽  
Vol 66 (22) ◽  
pp. 10953-10958 ◽  
Author(s):  
Boleslav Kosharskyy ◽  
Nicolas Solban ◽  
Sung K. Chang ◽  
Imran Rizvi ◽  
Yuchiao Chang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Combination Therapy ◽  
Tumor Growth ◽  
Local Tumor ◽  
Orthotopic Model ◽  
Tumor Growth And Metastasis ◽  
Local Tumor Growth

Antibody therapy to human L1CAM in a transgenic mouse model blocks local tumor growth but induces EMT

2014 ◽  
Vol 136 (5) ◽  
pp. E326-E339 ◽  
Author(s):  
Kai Doberstein ◽  
Patrick N. Harter ◽  
Uwe Haberkorn ◽  
Niko P. Bretz ◽  
Bernd Arnold ◽  
...  
Keyword(s):  
Mouse Model ◽  
Tumor Growth ◽  
Transgenic Mouse ◽  
Antibody Therapy ◽  
Transgenic Mouse Model ◽  
Local Tumor ◽  
Local Tumor Growth

scholarly journals Lymphadenectomy promotes tumor growth and cancer cell dissemination in the spontaneous RET mouse model of human uveal melanoma

Oncotarget ◽  
2015 ◽  
Vol 6 (42) ◽  
pp. 44806-44818 ◽  
Author(s):  
Yeo Kim Pin ◽  
Karen Khoo ◽  
Muly Tham ◽  
Tan Karwai ◽  
Thiam Chung Hwee ◽  
...  
Keyword(s):  
Mouse Model ◽  
Tumor Growth ◽  
Cancer Cell ◽  
Uveal Melanoma ◽  
Cell Dissemination

TSU-68 (SU6668) inhibits local tumor growth and liver metastasis of human colon cancer xenografts via anti-angiogenesis

2005 ◽  
Author(s):  
Kyoko Yorozuya ◽  
Tetsuro Kubota ◽  
Masahiko Watanabe ◽  
Hirotoshi Hasegawa ◽  
Soji Ozawa ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Liver Metastasis ◽  
Tumor Growth ◽  
Human Colon ◽  
Local Tumor ◽  
Human Colon Cancer ◽  
Local Tumor Growth

Morphine analgesia suppresses tumor growth and metastasis in a mouse model of cancer pain produced by orthotopic tumor inoculation

2002 ◽  
Vol 441 (3) ◽  
pp. 185-191 ◽  
Author(s):  
Takashi Sasamura ◽  
Shigenobu Nakamura ◽  
Yuko Iida ◽  
Hideki Fujii ◽  
Jun Murata ◽  
...  
Keyword(s):  
Mouse Model ◽  
Tumor Growth ◽  
Cancer Pain ◽  
Morphine Analgesia ◽  
Tumor Inoculation ◽  
Orthotopic Tumor ◽  
Tumor Growth And Metastasis
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