scholarly journals Natural killer cells: role in local tumor growth and metastasis

2012 ◽  
pp. 73 ◽  
Author(s):  
Nathalie Jacobs ◽  
Langers ◽  
Renoux ◽  
Thiry ◽  
Delvenne
Keyword(s):  
Natural Killer Cells ◽  
Tumor Growth ◽  
Natural Killer ◽  
Local Tumor ◽  
Killer Cells ◽  
Tumor Growth And Metastasis ◽  
Local Tumor Growth

scholarly journals Lung‐resident natural killer cells control pulmonary tumor growth in mice

2018 ◽  
Vol 109 (9) ◽  
pp. 2670-2676 ◽  
Author(s):  
Yutaka Yamamoto ◽  
Kiho Miyazato ◽  
Kei Takahashi ◽  
Naoki Yoshimura ◽  
Hideaki Tahara ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Tumor Growth ◽  
Natural Killer ◽  
Killer Cells ◽  
Pulmonary Tumor

Protective Role of Natural Killer Cells in Tumor Growth and Viral Infection in Mice

Pathobiology ◽  
1984 ◽  
Vol 52 (1-2) ◽  
pp. 40-43
Author(s):  
Sonoko Habu ◽  
Kazuo Shimanura ◽  
Ken-ichi Akamatsu ◽  
Ko Okumura ◽  
Norikazu Tamaoki
Keyword(s):  
Natural Killer Cells ◽  
Tumor Growth ◽  
Viral Infection ◽  
Natural Killer ◽  
Protective Role ◽  
Killer Cells

scholarly journals Angiostatic and chemotactic activities of the CXC chemokine CXCL4L1 (platelet factor-4 variant) are mediated by CXCR3

Blood ◽  
2011 ◽  
Vol 117 (2) ◽  
pp. 480-488 ◽  
Author(s):  
Sofie Struyf ◽  
Laura Salogni ◽  
Marie D. Burdick ◽  
Jo Vandercappellen ◽  
Mieke Gouwy ◽  
...  
Keyword(s):  
T Cells ◽  
Natural Killer Cells ◽  
Tumor Growth ◽  
Natural Killer ◽  
Platelet Factor 4 ◽  
Vascular Effects ◽  
Activated T Cells ◽  
Platelet Factor ◽  
Killer Cells ◽  
Cxc Chemokine

Abstract We investigated possible cellular receptors for the human CXC chemokine platelet factor-4 variant/CXCL4L1, a potent inhibitor of angiogenesis. We found that CXCL4L1 has lower affinity for heparin and chondroitin sulfate-E than platelet factor-4 (CXCL4) and showed that CXCL10 and CXCL4L1 could displace each other on microvascular endothelial cells. Labeled CXCL4L1 also bound to CXCR3A- and CXCR3B-transfectants and was displaced by CXCL4L1, CXCL4, and CXCL10. The CXCL4L1 anti-angiogenic activity was blocked by anti-CXCR3 antibodies (Abs) in the Matrigel and cornea micropocket assays. CXCL4L1 application in CXCR3−/− or in wild-type mice treated with neutralizing anti-CXCR3 Abs, resulted in reduced inhibitory activity of CXCL4L1 on tumor growth and vascularization of Lewis lung carcinoma. Furthermore, CXCL4L1 and CXCL4 chemoattracted activated T cells, human natural killer cells, and human immature dendritic cells (DCs). Migration of DCs toward CXCL4 and CXCL4L1 was desensitized by preincubation with CXCL10 and CXCL11, inhibited by pertussis toxin, and neutralized by anti-CXCR3 Abs. Chemotaxis of T cells, natural killer cells, and DCs is likely to contribute to the antitumoral action. However, the in vivo data indicate that the angiostatic property of CXCL4L1 is equally important in retarding tumor growth. Thus, both CXCR3A and CXCR3B are implicated in the chemotactic and vascular effects of CXCL4L1.

Whole-Body Bioluminescent Imaging of Human Uveal Melanoma in a New Mouse Model of Local Tumor Growth and Metastasis

2005 ◽  
Vol 46 (5) ◽  
pp. 1581 ◽  
Author(s):  
Irene C. Notting ◽  
Jeroen T. Buijs ◽  
Ivo Que ◽  
Ratna E. Mintardjo ◽  
Geertje van der Horst ◽  
...  
Keyword(s):  
Mouse Model ◽  
Tumor Growth ◽  
Uveal Melanoma ◽  
Whole Body ◽  
Bioluminescent Imaging ◽  
Local Tumor ◽  
Tumor Growth And Metastasis ◽  
Local Tumor Growth
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