scholarly journals Lymphadenectomy promotes tumor growth and cancer cell dissemination in the spontaneous RET mouse model of human uveal melanoma

Oncotarget ◽  
2015 ◽  
Vol 6 (42) ◽  
pp. 44806-44818 ◽  
Author(s):  
Yeo Kim Pin ◽  
Karen Khoo ◽  
Muly Tham ◽  
Tan Karwai ◽  
Thiam Chung Hwee ◽  
...  
Keyword(s):  
Mouse Model ◽  
Tumor Growth ◽  
Cancer Cell ◽  
Uveal Melanoma ◽  
Cell Dissemination

Whole-Body Bioluminescent Imaging of Human Uveal Melanoma in a New Mouse Model of Local Tumor Growth and Metastasis

2005 ◽  
Vol 46 (5) ◽  
pp. 1581 ◽  
Author(s):  
Irene C. Notting ◽  
Jeroen T. Buijs ◽  
Ivo Que ◽  
Ratna E. Mintardjo ◽  
Geertje van der Horst ◽  
...  
Keyword(s):  
Mouse Model ◽  
Tumor Growth ◽  
Uveal Melanoma ◽  
Whole Body ◽  
Bioluminescent Imaging ◽  
Local Tumor ◽  
Tumor Growth And Metastasis ◽  
Local Tumor Growth

Nerve Growth Factor overexpression in Clara cells suppresses metastasis and tumor growth in a mouse model of experimental lung metastasis

Pneumologie ◽  
2012 ◽  
Vol 66 (06) ◽  
Author(s):  
K Seidler ◽  
A Sydykov ◽  
S Müller-Brüsselbach ◽  
R Müller ◽  
N Weißmann ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Mouse Model ◽  
Tumor Growth ◽  
Lung Metastasis ◽  
Clara Cells ◽  
Nerve Growth

scholarly journals Mesothelin blockage by Amatuximab suppresses cell invasiveness, enhances gemcitabine sensitivity and regulates cancer cell stemness in mesothelin-positive pancreatic cancer cells

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Fumihiko Matsuzawa ◽  
Hirofumi Kamachi ◽  
Tatsuzo Mizukami ◽  
Takahiro Einama ◽  
Futoshi Kawamata ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Mouse Model ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Morphological Changes ◽  
Pancreatic Cancer Cells ◽  
Cell Invasiveness ◽  
And Migration ◽  
Migration Capacity

Abstract Background Mesothelin is a 40-kDa glycoprotein that is highly overexpressed in various types of cancers, however molecular mechanism of mesothelin has not been well-known. Amatuximab is a chimeric monoclonal IgG1/k antibody targeting mesothelin. We recently demonstrated that the combine therapy of Amatuximab and gemcitabine was effective for peritonitis of pancreatic cancer in mouse model. Methods We discover the role and potential mechanism of mesothelin blockage by Amatuximab in human pancreatic cells both expressing high or low level of mesothelin in vitro experiment and peritonitis mouse model of pancreatic cancer. Results Mesothelin blockage by Amatuximab lead to suppression of invasiveness and migration capacity in AsPC-1 and Capan-2 (high mesothelin expression) and reduce levels of pMET expression. The combination of Amatuximab and gemcitabine suppressed proliferation of AsPC-1 and Capan-2 more strongly than gemcitabine alone. These phenomena were not observed in Panc-1 and MIA Paca-2 (Mesothelin low expression). We previously demonstrated that Amatuximab reduced the peritoneal mass in mouse AsPC-1 peritonitis model and induced sherbet-like cancer cell aggregates, which were vanished by gemcitabine. In this study, we showed that the cancer stem cell related molecule such as ALDH1, CD44, c-MET, as well as proliferation related molecules, were suppressed in sherbet-like aggregates, but once sherbet-like aggregates attached to peritoneum, they expressed these molecules strongly without the morphological changes. Conclusions Our work suggested that Amatuximab inhibits the adhesion of cancer cells to peritoneum and suppresses the stemness and viability of those, that lead to enhance the sensitivity for gemcitabine.

EFFECT OF INTERMITTENT FASTING ON PROSTATE CANCER TUMOR GROWTH IN A MOUSE MODEL

2009 ◽  
Vol 181 (4S) ◽  
pp. 53-53
Author(s):  
Jean A Thomas ◽  
Susan Poulton ◽  
Tameika Phillips ◽  
Jessica C. Lloyd ◽  
Jodi Antonelli ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Mouse Model ◽  
Tumor Growth ◽  
Intermittent Fasting ◽  
Cancer Tumor
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