Antibody therapy to human L1CAM in a transgenic mouse model blocks local tumor growth but induces EMT

2014 ◽  
Vol 136 (5) ◽  
pp. E326-E339 ◽  
Author(s):  
Kai Doberstein ◽  
Patrick N. Harter ◽  
Uwe Haberkorn ◽  
Niko P. Bretz ◽  
Bernd Arnold ◽  
...  
Keyword(s):  
Mouse Model ◽  
Tumor Growth ◽  
Transgenic Mouse ◽  
Antibody Therapy ◽  
Transgenic Mouse Model ◽  
Local Tumor ◽  
Local Tumor Growth

Hedgehog Inhibition With Cyclopamine Represses Tumor Growth and Prolongs Survival in a Transgenic Mouse Model of Islet Cell Tumors

2011 ◽  
Vol 253 (3) ◽  
pp. 546-552 ◽  
Author(s):  
Volker Fendrich ◽  
Johannes Rehm ◽  
Jens Waldmann ◽  
Malte Buchholz ◽  
Gerhard Christofori ◽  
...  
Keyword(s):  
Mouse Model ◽  
Tumor Growth ◽  
Transgenic Mouse ◽  
Islet Cell ◽  
Transgenic Mouse Model ◽  
Islet Cell Tumors

scholarly journals Establishment of an Endoscopy-Guided Minimally Invasive Orthotopic Mouse Model of Colorectal Cancer

Cancers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 3007
Author(s):  
Chen Chen ◽  
Jens Neumann ◽  
Florian Kühn ◽  
Serene M. L. Lee ◽  
Moritz Drefs ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mouse Model ◽  
Minimally Invasive ◽  
Tumor Growth ◽  
Hepatic Metastases ◽  
Specific Cell ◽  
Local Tumor ◽  
Orthotopic Mouse Model ◽  
Endoscopic Score ◽  
Local Tumor Growth

Open orthotopic mouse models of colorectal cancer have disadvantages such as the requirement for advanced surgical skills or the trauma caused by laparotomy. To overcome these drawbacks, this study aimed to evaluate the establishment of a minimally invasive model using murine colonoscopy. CT26 and MC38 CRC cells of different concentrations were injected into BALB/C and C57BL/6J mice, respectively. Follow-up endoscopies were performed to assign an endoscopic score to tumor growth. Gross autopsy, histologic and immuno-histochemical evaluation, and immune scoring were performed. To describe the learning curve of the procedures, a performance score was given. Local tumor growth with colorectal wall infiltration, luminal ulceration, the presence of tumor-infiltrating lymphocytes, lympho-vascular invasion, and early spontaneous lymph node, peritoneal, and hepatic metastases were observed. The tumors showed cytoplasmic immuno-staining for CK20. Compared to the MC38/C57BL/6J model, tumorigenicity and immunogenicity of the CT26/BALB/C model were higher. Tumor volume correlated with the endoscopic score. This endoscopy-guided orthotopic mouse model is easy to learn and quick to establish. It features early metastasis and enables the study of interactions with the immune system. When specific cell concentrations and cell lines are applied, controlled local tumor growth and metastasis can be achieved within short observation periods.

Tissue inhibitor of metalloproteinases-1 (TIMP-1) inhibits tumor growth and angiogenesis in the TIMP-1 transgenic mouse model

2003 ◽  
Vol 105 (3) ◽  
pp. 340-346 ◽  
Author(s):  
Yasuhide Ikenaka ◽  
Hitoshi Yoshiji ◽  
Shigeki Kuriyama ◽  
Junichi Yoshii ◽  
Ryuichi Noguchi ◽  
...  
Keyword(s):  
Mouse Model ◽  
Tumor Growth ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
Tissue Inhibitor Of Metalloproteinases ◽  
Tissue Inhibitor

Whole-Body Bioluminescent Imaging of Human Uveal Melanoma in a New Mouse Model of Local Tumor Growth and Metastasis

2005 ◽  
Vol 46 (5) ◽  
pp. 1581 ◽  
Author(s):  
Irene C. Notting ◽  
Jeroen T. Buijs ◽  
Ivo Que ◽  
Ratna E. Mintardjo ◽  
Geertje van der Horst ◽  
...  
Keyword(s):  
Mouse Model ◽  
Tumor Growth ◽  
Uveal Melanoma ◽  
Whole Body ◽  
Bioluminescent Imaging ◽  
Local Tumor ◽  
Tumor Growth And Metastasis ◽  
Local Tumor Growth

CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or docetaxel in a transgenic mouse model

2010 ◽  
Vol 129 (1) ◽  
pp. 225-232 ◽  
Author(s):  
Saima Hassan ◽  
Marguerite Buchanan ◽  
Kaushar Jahan ◽  
Adriana Aguilar-Mahecha ◽  
Louis Gaboury ◽  
...  
Keyword(s):  
Mouse Model ◽  
Tumor Growth ◽  
Transgenic Mouse ◽  
Breast Tumor ◽  
Transgenic Mouse Model ◽  
Primary Breast Tumor ◽  
Anti Vegf ◽  
Peptide Antagonist

scholarly journals MFG-E8/Lactadherin Promotes Tumor Growth in an Angiogenesis-Dependent Transgenic Mouse Model of Multistage Carcinogenesis

2007 ◽  
Vol 67 (14) ◽  
pp. 6777-6785 ◽  
Author(s):  
Melanie Neutzner ◽  
Theresa Lopez ◽  
Xu Feng ◽  
Elke S. Bergmann-Leitner ◽  
Wolfgang W. Leitner ◽  
...  
Keyword(s):  
Mouse Model ◽  
Tumor Growth ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
Multistage Carcinogenesis
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