Constructing Tissue Engineered Nucleus Pulposus with Adipose-Derived Stem Cells and an Injectable Thermosensitive Chitosan Scaffold

2014 ◽  
Vol 4 (12) ◽  
pp. 1073-1079 ◽  
Author(s):  
Tianyong Wen ◽  
Chao Zhang ◽  
Dike Ruan ◽  
Fang Li ◽  
Jian Ma
Keyword(s):  
Stem Cells ◽  
Nucleus Pulposus ◽  
Adipose Derived Stem Cells ◽  
Chitosan Scaffold

Injectable decellularized nucleus pulposus-based cell delivery system for differentiation of adipose-derived stem cells and nucleus pulposus regeneration

2018 ◽  
Vol 81 ◽  
pp. 115-128 ◽  
Author(s):  
Xiaopeng Zhou ◽  
Jingkai Wang ◽  
Xianpeng Huang ◽  
Weijing Fang ◽  
Yiqing Tao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Nucleus Pulposus ◽  
Delivery System ◽  
Cell Delivery ◽  
Adipose Derived Stem Cells

scholarly journals IFATS Collection: Human Adipose-Derived Stem Cells Seeded on a Silk Fibroin-Chitosan Scaffold Enhance Wound Repair in a Murine Soft Tissue Injury Model

Stem Cells ◽  
2009 ◽  
Vol 27 (1) ◽  
pp. 250-258 ◽  
Author(s):  
Andrew M. Altman ◽  
Yasheng Yan ◽  
Nadine Matthias ◽  
Xiaowen Bai ◽  
Carmen Rios ◽  
...  
Keyword(s):  
Stem Cells ◽  
Soft Tissue ◽  
Silk Fibroin ◽  
Wound Repair ◽  
Tissue Injury ◽  
Soft Tissue Injury ◽  
Adipose Derived Stem Cells ◽  
Chitosan Scaffold ◽  
Injury Model

Design of a Bioreactor for Mechanical Stimulation of Adipose Derived Stem Cells for Intervertebral Disc Tissue Engineering

2012 ◽  
Author(s):  
Heather Cleary ◽  
Thomas Barkley ◽  
Adam Goodman ◽  
Michael Payne ◽  
John Virtue ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Nucleus Pulposus ◽  
Disc Degeneration ◽  
Compressive Loading ◽  
Cartilage Regeneration ◽  
Adipose Derived Stem Cells ◽  
Medical Problems ◽  
Tissue Engineering Scaffolds ◽  
Engineering Strategy

Lower back pain is one of the most common medical problems in the world [1], affecting between 70% and 85% of the US population at some point during their lives [2]. Disc degeneration is caused by biological changes in the disc, which result in dehydration of the nucleus pulposus (NP). The long term goal of this project is to treat disc degeneration with a tissue engineering strategy for the regeneration of the nucleus pulposus using messechymal stem cells derived from adipose tissue. It has been established in cartilage regeneration studies that cyclic compressive loading of stem cells is beneficial for tissue formation compared to static culture [3–7]. In this work, a bioreactor is being developed that can subject cell-seeded polymeric tissue engineering scaffolds to dynamic compressive forces. Ultimately, the bioreactor will be used to study the effects of different loading parameters on the production of new nucleus pulposus tissue from adipose-derived stem cells.

Osmolarity controls the differentiation of adipose-derived stem cells into nucleus pulposus cells via histone demethylase KDM4B

2020 ◽  
Vol 472 (1-2) ◽  
pp. 157-171
Author(s):  
Yujie Zhang ◽  
Yanyan Wang ◽  
Xiaopeng Zhou ◽  
Jingkai Wang ◽  
Mingmin Shi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Nucleus Pulposus ◽  
Histone Demethylase ◽  
Adipose Derived Stem Cells ◽  
Nucleus Pulposus Cells
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