scholarly journals IFATS Collection: Human Adipose-Derived Stem Cells Seeded on a Silk Fibroin-Chitosan Scaffold Enhance Wound Repair in a Murine Soft Tissue Injury Model

Stem Cells ◽  
2009 ◽  
Vol 27 (1) ◽  
pp. 250-258 ◽  
Author(s):  
Andrew M. Altman ◽  
Yasheng Yan ◽  
Nadine Matthias ◽  
Xiaowen Bai ◽  
Carmen Rios ◽  
...  
Keyword(s):  
Stem Cells ◽  
Soft Tissue ◽  
Silk Fibroin ◽  
Wound Repair ◽  
Tissue Injury ◽  
Soft Tissue Injury ◽  
Adipose Derived Stem Cells ◽  
Chitosan Scaffold ◽  
Injury Model

Establishment of soft-tissue-injury model of high-voltage electrical burn and observation of its pathological changes

Burns ◽  
2009 ◽  
Vol 35 (8) ◽  
pp. 1158-1164 ◽  
Author(s):  
Chai Jia-ke ◽  
Li Li-gen ◽  
Gao Quan-wen ◽  
Shen Xiao-peng ◽  
Zhang Hai-jun ◽  
...  
Keyword(s):  
Soft Tissue ◽  
High Voltage ◽  
Tissue Injury ◽  
Soft Tissue Injury ◽  
Pathological Changes ◽  
Injury Model

Determination of Elbow Laxity in a Sequential Soft-Tissue Injury Model

2018 ◽  
Vol 100 (7) ◽  
pp. 564-571 ◽  
Author(s):  
Marc Schnetzke ◽  
Moritz Bergmann ◽  
Kilian Wegmann ◽  
Lars-Peter Müller ◽  
Stephan Grechenig ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Tissue Injury ◽  
Soft Tissue Injury ◽  
Injury Model

Biomechanical Effect on Joint Stability of Including Deltoid Ligament Repair in an Ankle Fracture Soft Tissue Injury Model With Deltoid and Syndesmotic Disruption

2020 ◽  
Vol 41 (9) ◽  
pp. 1158-1164
Author(s):  
Pablo Mococain ◽  
Lorena Bejarano-Pineda ◽  
Richard Glisson ◽  
Rishin J. Kadakia ◽  
Craig C. Akoh ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Ankle Fracture ◽  
Tissue Injury ◽  
External Rotation ◽  
Soft Tissue Injury ◽  
Ankle Fractures ◽  
Deltoid Ligament ◽  
Ligament Repair ◽  
Injury Model ◽  
Biomechanical Effect

Background: The current operative standard of treatment for bimalleolar equivalent ankle fracture is open reduction and internal fixation (ORIF) of the lateral malleolus followed by syndesmotic stabilization if indicated. There is controversy surrounding the indication and need for deltoid ligament repair in this setting. The purpose of this study was to quantify the biomechanical effect of deltoid ligament repair in an ankle fracture soft tissue injury model. Methods: Nine fresh-frozen cadaveric specimens were included in this study. Each leg was tested under 5 conditions: intact, syndesmosis and deltoid ligament sectioned, syndesmosis fixed, deltoid repaired, and both the syndesmosis and deltoid ligament repaired. Anterior, posterior, lateral, and medial drawer and rotational stresses were applied to the foot, and the resulting talus displacement was documented. Results: Isolated deltoid repair significantly reduced anterior displacement to normal levels. Displacement with lateral drawer testing was not significantly corrected until both structures were repaired. Deltoid repair and syndesmosis fixation each reduced internal rotation significantly with further reduction to normal levels when both were repaired. External rotation remained elevated relative to the intact condition regardless of which structures were repaired. Conclusion: There is existing controversy regarding the importance of deltoid ligament repair in the setting of ankle fractures. The findings of this biomechanical study indicate that deltoid ligament repair enhances ankle stability in ankle fractures with both syndesmotic and deltoid disruption. Clinical Relevance: Concomitant deltoid ligament repair in addition to stabilization of fracture and syndesmosis may improve long-term functioning of the ankle joint and clinical outcomes.

Exogenous Administration of Substance P Enhances Wound Healing in a Novel Skin-Injury Model

2005 ◽  
Vol 230 (4) ◽  
pp. 271-280 ◽  
Author(s):  
Angel V. Delgado ◽  
Albert T. McManus ◽  
James P. Chambers
Keyword(s):  
Wound Healing ◽  
Nervous System ◽  
Soft Tissue ◽  
Substance P ◽  
Wound Repair ◽  
Tissue Injury ◽  
Soft Tissue Injury ◽  
Inflammatory Cells ◽  
Target Cells

Soft tissue injury accounts for approximately 44% of all wounds in both the military and civilian populations. Following injury to soft tissue, Substance P (SP) and other neuropeptides are released by cutaneous neurons and modulate the function of immunocompetent and inflammatory cells, as well as epithelial and endothelial cells. The interaction between these components of the nervous system and multiple target cells affecting cutaneous repair is of increasing interest. In this report, we describe the effects of SP on wound repair in a novel, laser-induced, skin-wound model. Gross and histologic examination of laser-induced injury revealed that exogenously administered SP affects wound healing via neurite outgrowth, in addition to adhesion molecule and neurokinin-1 receptor involvement in vivo. All SP effects were decreased by pretreatment with Spantide II, an SP antagonist. The elucidation of SP-mediating mechanisms is crucial to firmly establishing the involvement and interaction of the peripheral nervous system and the immune system in cutaneous repair. Findings presented here suggest that SP participates in the complex network of mediators involved in cutaneous inflammation and wound healing.

Auto seat restraint soft-tissue injury

1987 ◽  
Vol 148 (2) ◽  
pp. 458-458 ◽  
Author(s):  
DR Pennes ◽  
WA Phillips
Keyword(s):  
Soft Tissue ◽  
Tissue Injury ◽  
Soft Tissue Injury

scholarly journals Stamina-Enhancing Effects of Human Adipose-Derived Stem Cells

2021 ◽  
Vol 30 ◽  
pp. 096368972110354
Author(s):  
Eun-Jung Yoon ◽  
Hye Rim Seong ◽  
Jangbeen Kyung ◽  
Dajeong Kim ◽  
Sangryong Park ◽  
...  
Keyword(s):  
Physical Activity ◽  
Stem Cells ◽  
Locomotor Activity ◽  
Tissue Injury ◽  
Male Rats ◽  
Adipose Derived Stem Cells ◽  
Sprague Dawley ◽  
Serum Triglycerides

Stamina-enhancing effects of human adipose derived stem cells (hADSCs) were investigated in young Sprague-Dawley rats. Ten-day-old male rats were transplanted intravenously (IV) or intracerebroventricularly (ICV) with hADSCs (1 × 106 cells/rat), and physical activity was measured by locomotor activity and rota-rod performance at post-natal day (PND) 14, 20, 30, and 40, as well as a forced swimming test at PND 41. hADSCs injection increased the moving time in locomotor activity, the latency in rota-rod performance, and the maximum swimming time. For the improvement of physical activity, ICV transplantation was superior to IV injection. In biochemical analyses, ICV transplantation of hADSCs markedly reduced serum creatine phosphokinase, lactate dehydrogenase, alanine transaminase, and muscular lipid peroxidation, the markers for muscular and hepatic injuries, despite the reduction in muscular glycogen and serum triglycerides as energy sources. Notably, hADSCs secreted brain-derived neurotrophic factor (BDNF) and nerve growth factor in vitro, and increased the level of BDNF in the brain and muscles in vivo. The results indicate that hADSCs enhance physical activity including stamina not only by attenuating tissue injury, but also by strengthening the muscles via production of BDNF.

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