Plasmacytoid Dendritic Cells from Human Lung Cancer Draining Lymph Nodes Induce Tc1 Responses

2007 ◽  
Vol 36 (3) ◽  
pp. 360-367 ◽  
Author(s):  
Alexander Faith ◽  
Emma Peek ◽  
Joanne McDonald ◽  
Zoe Urry ◽  
David F. Richards ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dendritic Cells ◽  
Lymph Nodes ◽  
Human Lung ◽  
Plasmacytoid Dendritic Cells ◽  
Human Lung Cancer ◽  
Draining Lymph Nodes

scholarly journals Human Lung Cancer–Derived Immunosuppressive Plasmacytoid Dendritic Cells Release IL-1α in an AIM2 Inflammasome-Dependent Manner

2015 ◽  
Vol 185 (11) ◽  
pp. 3115-3124 ◽  
Author(s):  
Rosalinda Sorrentino ◽  
Michela Terlizzi ◽  
Vincenzo G. Di Crescenzo ◽  
Ada Popolo ◽  
Michela Pecoraro ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dendritic Cells ◽  
Human Lung ◽  
Plasmacytoid Dendritic Cells ◽  
Human Lung Cancer ◽  
Dependent Manner

scholarly journals Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase

2007 ◽  
Vol 117 (9) ◽  
pp. 2570-2582 ◽  
Author(s):  
Madhav D. Sharma ◽  
Babak Baban ◽  
Phillip Chandler ◽  
De-Yan Hou ◽  
Nagendra Singh ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Lymph Nodes ◽  
Plasmacytoid Dendritic Cells ◽  
Mouse Tumor ◽  
Indoleamine 2,3 Dioxygenase ◽  
Draining Lymph Nodes

scholarly journals Dendritic Cell Populations in Leishmania major-Infected Skin and Draining Lymph Nodes

2004 ◽  
Vol 72 (4) ◽  
pp. 1991-2001 ◽  
Author(s):  
Tracey Baldwin ◽  
Sandrine Henri ◽  
Joan Curtis ◽  
Meredith O'Keeffe ◽  
David Vremec ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Dendritic Cell ◽  
Lymph Nodes ◽  
Leishmania Major ◽  
Mouse Skin ◽  
Parasite Load ◽  
Plasmacytoid Dendritic Cells ◽  
Cell Populations ◽  
Infection Model ◽  
Draining Lymph Nodes

ABSTRACT Using a metacyclic promastigote ear infection model of cutaneous leishmaniasis, we examined the phenotype, parasite load, and cytokine production of dendritic cells in the skin and draining lymph nodes of resistant C57BL/6J and susceptible BALB/c mice. Five dendritic cell populations were isolated from the skin and lymph nodes, and the main difference between the groups of mice was an increased number of plasmacytoid dendritic cells in the lymph nodes of the susceptible mice. Although similar cell types were present in the skin emigrants of both strains, there was a 10-fold larger number of cells in BALB/c mouse skin early in infection than in C57BL/6J mouse skin. None of the dendritic cells in the lymph nodes harbored parasites until 3 weeks after infection, with the Langerhans cells having the largest load and the plasmacytoid dendritic cells having the smallest load but the longest lasting infection. Although parasites could be detected in the lymph nodes a few hours after infection, none of the skin emigrants harbored parasites, indicating that they are not the vehicle that ferries the parasites from the skin to the lymph nodes. The presence of larger numbers of plasmacytoid cells in infected BALB/c mice, the more protracted infection of these cells, and their production of alpha interferon point to a complex and important role for the plasmacytoid cells in leishmaniasis.

Prospective phase II study of post-surgical adjuvant chemo-immunotherapy using autologous dendritic cells and activated killer cells from tissue culture of tumor draining lymph nodes in primary lung cancer patients

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 3048-3048
Author(s):  
H. Kimura ◽  
T. Iizasa ◽  
A. Ishikawa
Keyword(s):  
Lung Cancer ◽  
Tissue Culture ◽  
Dendritic Cells ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Phase Ii Study ◽  
Primary Lung Cancer ◽  
Killer Cells ◽  
Lung Cancer Patients ◽  
Draining Lymph Nodes

3048 Background: We conducted a phase II study to evaluate the efficacy and toxicity of adjuvant chemo-immunotherapy using dendritic cells and activated killer cells from tissue culture of tumor-draining lymph nodes (TDLN) in primary lung cancer patients. Methods: Pathological N2 lung cancer patients were selected for the post-surgical adjuvant chemo-immunotherapy. Activated killer cells and dendritic cells obtained from tissue cultures of TDLN or TDLN co-cultured with peripheral blood lymphocytes (TDLN-Pb) were used for the adoptive transfer of immunotherapy. Patients received 4 courses of post-surgical chemotherapy or chemotherapy along with immunotherapy (immunotherapy group) every 2 months for 2 years. Results: There were 57 N2 patients eligible for the study, 28 for immunotherapy and 29 for chemotherapy. For the 28 immunotherapy cases, a total of 313 courses of immunotherapy were administered. The main toxicities were fever (78.0%), chill (83.4%). The 5-year survival rates in the immunotherapy and chemotherapy groups were 56.5% and 12.5% respectively. Among the variables analyzed, immunotherapy was the most significant independent prognostic factor (p=0.0042.) Conclusions: Adoptive transfer of activated killer cells and dendritic cells from the tumor draining lymph nodes of primary lung cancer patients is safe and feasible, and a large-scale multi-institutional study is necessary for the evaluation of the efficacy of this treatment. No significant financial relationships to disclose.

scholarly journals Antitumor Activity of Lentivirus-mediated Interleukin -12 Gene Modified Dendritic Cells in Human Lung Cancer in Vitro

2014 ◽  
Vol 15 (2) ◽  
pp. 611-616 ◽  
Author(s):  
Hassan Abdellah Ahmed Ali ◽  
Jun Di ◽  
Wu Mei ◽  
Yu-Cheng Zhang ◽  
Yi Li ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dendritic Cells ◽  
Antitumor Activity ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Interleukin 12

scholarly journals Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes

2004 ◽  
Vol 114 (2) ◽  
pp. 280-290 ◽  
Author(s):  
David H. Munn ◽  
Madhav D. Sharma ◽  
Deyan Hou ◽  
Babak Baban ◽  
Jeffrey R. Lee ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Lymph Nodes ◽  
Plasmacytoid Dendritic Cells ◽  
Indoleamine 2,3 Dioxygenase ◽  
Draining Lymph Nodes
Sign in / Sign up

Export Citation Format

Share Document