Plasmacytoid dendritic cells regulate host immune response to Citrobacter rodentium induced colitis in colon‐draining lymph nodes

2020 ◽  
Author(s):  
Sakari Pöysti ◽  
Satu Silojärvi ◽  
Raine Toivonen ◽  
Arno Hänninen
Keyword(s):  
Immune Response ◽  
Dendritic Cells ◽  
Lymph Nodes ◽  
Host Immune Response ◽  
Plasmacytoid Dendritic Cells ◽  
Citrobacter Rodentium ◽  
Draining Lymph Nodes

Plasmacytoid Dendritic Cells from Human Lung Cancer Draining Lymph Nodes Induce Tc1 Responses

2007 ◽  
Vol 36 (3) ◽  
pp. 360-367 ◽  
Author(s):  
Alexander Faith ◽  
Emma Peek ◽  
Joanne McDonald ◽  
Zoe Urry ◽  
David F. Richards ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dendritic Cells ◽  
Lymph Nodes ◽  
Human Lung ◽  
Plasmacytoid Dendritic Cells ◽  
Human Lung Cancer ◽  
Draining Lymph Nodes

scholarly journals Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase

2007 ◽  
Vol 117 (9) ◽  
pp. 2570-2582 ◽  
Author(s):  
Madhav D. Sharma ◽  
Babak Baban ◽  
Phillip Chandler ◽  
De-Yan Hou ◽  
Nagendra Singh ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Lymph Nodes ◽  
Plasmacytoid Dendritic Cells ◽  
Mouse Tumor ◽  
Indoleamine 2,3 Dioxygenase ◽  
Draining Lymph Nodes

scholarly journals Dendritic Cell Populations in Leishmania major-Infected Skin and Draining Lymph Nodes

2004 ◽  
Vol 72 (4) ◽  
pp. 1991-2001 ◽  
Author(s):  
Tracey Baldwin ◽  
Sandrine Henri ◽  
Joan Curtis ◽  
Meredith O'Keeffe ◽  
David Vremec ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Dendritic Cell ◽  
Lymph Nodes ◽  
Leishmania Major ◽  
Mouse Skin ◽  
Parasite Load ◽  
Plasmacytoid Dendritic Cells ◽  
Cell Populations ◽  
Infection Model ◽  
Draining Lymph Nodes

ABSTRACT Using a metacyclic promastigote ear infection model of cutaneous leishmaniasis, we examined the phenotype, parasite load, and cytokine production of dendritic cells in the skin and draining lymph nodes of resistant C57BL/6J and susceptible BALB/c mice. Five dendritic cell populations were isolated from the skin and lymph nodes, and the main difference between the groups of mice was an increased number of plasmacytoid dendritic cells in the lymph nodes of the susceptible mice. Although similar cell types were present in the skin emigrants of both strains, there was a 10-fold larger number of cells in BALB/c mouse skin early in infection than in C57BL/6J mouse skin. None of the dendritic cells in the lymph nodes harbored parasites until 3 weeks after infection, with the Langerhans cells having the largest load and the plasmacytoid dendritic cells having the smallest load but the longest lasting infection. Although parasites could be detected in the lymph nodes a few hours after infection, none of the skin emigrants harbored parasites, indicating that they are not the vehicle that ferries the parasites from the skin to the lymph nodes. The presence of larger numbers of plasmacytoid cells in infected BALB/c mice, the more protracted infection of these cells, and their production of alpha interferon point to a complex and important role for the plasmacytoid cells in leishmaniasis.

scholarly journals Differential Recruitment of Dendritic Cells Subsets to Lymph Nodes Correlates with a Protective or Permissive T-Cell Response duringLeishmania(Viannia)BraziliensisorLeishmania(Leishmania)AmazonensisInfection

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
A. K. Carvalho ◽  
K. Carvalho ◽  
L. F. D. Passero ◽  
M. G. T. Sousa ◽  
V. L. R. da Matta ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Dendritic Cells ◽  
Lymph Nodes ◽  
T Lymphocyte ◽  
Langerhans Cells ◽  
T Cell Response ◽  
Lymphocyte Response ◽  
Draining Lymph Nodes ◽  
Th1 Immune Response

Leishmania (L.) amazonensis(La) andL. (V.) braziliensis(Lb) are responsible for a large clinical and immunopathological spectrum in human disease; whileLamay be responsible for anergic disease,Lbinfection leads to cellular hypersensitivity. To better understand the dichotomy in the immune response caused by theseLeishmaniaspecies, we evaluated subsets of dendritic cells (DCs) and T lymphocyte in draining lymph nodes during the course ofLaandLbinfection in BALB/c mice. Our results demonstrated a high involvement of DCs inLainfection, which was characterized by the greater accumulation of Langerhans cells (LCs); conversely,Lbinfection led to an increase in dermal DCs (dDCs) throughout the infection. Considering the T lymphocyte response, an increase of effector, activated, and memory CD4+T-cells was observed inLbinfection. Interleukin- (IL-) 4- and IL-10-producing CD4+and CD8+T-cells were present in bothLaandLbinfection; however, interferon- (IFN-)γ-producing CD4+and CD8+T-cells were detected only inLbinfection. The results suggest that duringLbinfection, the dDCs were the predominant subset of DCs that in turn was associated with the development of Th1 immune response; in contrastLainfection was associated with a preferential accumulation of LCs and total blockage of the development of Th1 immune response.

scholarly journals Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes

2004 ◽  
Vol 114 (2) ◽  
pp. 280-290 ◽  
Author(s):  
David H. Munn ◽  
Madhav D. Sharma ◽  
Deyan Hou ◽  
Babak Baban ◽  
Jeffrey R. Lee ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Lymph Nodes ◽  
Plasmacytoid Dendritic Cells ◽  
Indoleamine 2,3 Dioxygenase ◽  
Draining Lymph Nodes

scholarly journals Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes

2004 ◽  
Vol 114 (4) ◽  
pp. 599-599 ◽  
Author(s):  
David H. Munn ◽  
Madhav D. Sharma ◽  
Deyan Hou ◽  
Babak Baban ◽  
Jeffrey R. Lee ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Lymph Nodes ◽  
Plasmacytoid Dendritic Cells ◽  
Indoleamine 2,3 Dioxygenase ◽  
Draining Lymph Nodes
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