scholarly journals Choroid Metastasis in a Patient with Squamous Cell Carcinoma of the Uterine Cervix: A Case Report

2020 ◽  
Vol 11 (3) ◽  
pp. 630-638
Author(s):  
Ángel García Vásquez ◽  
Gabriela Thomassiny Bautista ◽  
María José Sardá Ramirez ◽  
Janet Amelia Moheno Lozano ◽  
Oscar Solorzano Enriquez ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Squamous Cell Carcinoma ◽  
Uterine Cervix ◽  
Case Reports ◽  
Serous Retinal Detachment ◽  
Advanced Stage ◽  
Choroidal Metastasis ◽  
History Of ◽  
Ocular Metastasis ◽  
Rule Out

We present the case of a 43-year-old woman with unilateral loss of vision who had a history of cervical cancer, staged as FIGO IIIB, and who had undergone previous chemotherapy and radiotherapy, but was not a surgical candidate. An examination revealed serous retinal detachment with an underlying choroidal mass in the left eye. We reviewed all available published case reports of uterine cervix metastases to the eye and adnexa and compiled all information into a table to present clinical and epidemiological findings. Unilateral choroidal metastasis arising from cervical cancer is extremely rare. In most cases, a history of cervical carcinoma is confirmed in the advanced stage of the disease. Ocular metastasis may be the presenting feature of primary cervical malignancy; therefore, to rule out malignancy in every woman who develops these clinical features, a cervical examination should be included in the workup.

Changing Incidence of Invasive Adenocarcinoma of the Uterine Cervix in East Anglia

1997 ◽  
Vol 4 (1) ◽  
pp. 40-43 ◽  
Author(s):  
Diane Stockton ◽  
Pauline Cooper ◽  
R N Lonsdale
Keyword(s):  
Cervical Cancer ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Birth Cohort ◽  
Squamous Cell ◽  
Uterine Cervix ◽  
Invasive Adenocarcinoma ◽  
East Anglia ◽  
The Mean ◽  
Age Shift

Objective— To determine trends in incidence of invasive adenocarcinoma of the uterine cervix in East Anglia. Methods— Cervical cancer incidence data for both squamous cell carcinomas and adenocarcinomas were obtained from the East Anglian Cancer Registry for the period 1971–94. Similar data were obtained for England and Wales. European age standardised rates (ASRs) were used for comparisons. Results— The mean incidence (ASR) of cervical adenocarcinoma was 0.85 per 10s in 1971–76, rising to 2.54 per 105 in 1989–94. There has been a marked age shift, with the main increase in incidence occurring in younger women aged 30–39. The mean incidence (ASR) of squamous cell carcinoma of the cervix has decreased from 9.78 to 8.74 per 10s over the periods 1971–76 and 1989–94. Again there has been an age shift, moving from a single incidence peak in the 4S-S9 age band in earlier years to incidence peaks in both the 30–39 and 55–69 age bands in more recent years. Similar trends were noted when data for England and Wales were analysed. Birth cohort analyses show that both tumours are occurring progressively earlier (about five years earlier in each five year birth cohort). Conclusion— Although the overall incidence of cervical carcinoma is declining, this study has shown an increased incidence of cervical adenocarcinoma, particularly in the younger age groups. In future it would seem advisable to publish separate incidence and mortality data for squamous cell carcinoma and adenocarcinoma of the uterine cervix. All practitioners involved in the cervical cancer screening programme would then be aware of the very real significance of this tumour.

scholarly journals Immunohistochemical Expression of p53 and Bcl-2 in Algerian Cervical Carcinoma

2018 ◽  
Vol 11 (1) ◽  
pp. 67-75
Author(s):  
Deffar Khalissa ◽  
Khenchouche Abdelhalim ◽  
Xing Xie ◽  
Ying Li ◽  
Ouhida Soraya ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Prognostic Marker ◽  
Uterine Cervix ◽  
Prognostic Markers ◽  
P53 Protein ◽  
Immunohistochemical Expression ◽  
Important Indicator ◽  
P53 Expression

The Objective of the present study is to evaluate the expression levels of Bcl-2 and p53 proteins in squamous cell carcinoma and adenocarcinoma of the uterine cervix, and try to explain their role as prognostic markers for this cancer. The cohort comprised 90 cases of the cervix lesions. The samples were assessed by immunohistochemistry for the expression of Bcl-2 and p53 proteins. The results showed that the Bcl-2 expression was either absent, low or moderate respectively in 38.96%; 50.65% and 10.39% of SCC cases. However, it was absent or expressed in 76.92% and 23.08% of adenocarcinoma cases respectively. The p53 protein was absent or present respectively in 75.32% and 24.68% of SCC cases as demonstrated by immunohistochemistry. p53 was almost absent in adenocarcinoma samples where only 7.70% of cases were positive. There was no significant correlation between Bcl-2 and p53 expression (p=0.352). We conclude that p53 expression, detected by immunohistochemistry, does not appear to be a prognostic marker for cervical cancer. Nevertheless, Bcl-2 expression seems to provide more information for this disease. It may represent an important indicator for cervical cancer.

scholarly journals Gambaran Kejadian Kanker Serviks Di RSUD Ulin Banjarmasin

2019 ◽  
pp. 47-52
Author(s):  
Elvine Ivana Kabuhung ◽  
Novalia Widiya Ningrum
Keyword(s):  
Cervical Cancer ◽  
Cancer Patients ◽  
Hormonal Contraception ◽  
Descriptive Study ◽  
Sampling Techniques ◽  
Advanced Stage ◽  
Papilloma Virus ◽  
Past Life ◽  
History Of ◽  
Human Papiloma Virus

Latar belakang: Kanker serviks adalah keganasan yang terjadi pada serviks disebabkan oleh Human Papiloma Virus (HPV). Insiden kanker serviks semakin mmeningkat. Data dari RSUD Ulin Banjarmasin didapatkan bahwa tahun 2012 hingga tahun 2014 terjadi peningkatan kasus baru penderita knker serviks.Tujuan penelitian: Menggambarkan kejadian kanker serviks di Poli Kandungan RSUD Ulin Banjarmasin.Metode: Penelitian ini merupakan penelitian deskriptif dengan teknik pengambilan sampel yaitu accidental sampling sebanyak 30 orang pasien kanker serviks.Hasil penelitian: Pasien kanker serviks di Poli Kandungan RSUD Ulin Banjarmasin paling banyak pada stadium II dan III, pertama kali melakukan hubungan seksual pada umur 20 tahun, memiliki paritas multipara, dan memiliki riwayar penggunaan kontrasepsi hormonal.Simpulan: Pasien kanker serviks datang pada stadium lanjut dan kanker serviks ditimbulkan karena perilaku kehidupan yang lalu. Kata kunci: Kanker serviks ABSTRACT Background: Cervical cancer is malignancy that occurs in the cervix caused by the Human Papilloma Virus (HPV). The incidence of cervical cancer is increasing. Data from RSUD Ulin Banjarmasin found that in 2012 to 2014 there was an increase in new cases of patients with cervical cancer.Objective: Describe the incidence of cervical cancer in the Poly Womb of RSUD Ulin Banjarmasin.Methods: This research is a descriptive study with sampling techniques namely accidental sampling as many as 30 people with cervical cancer patients.Results: Cervical cancer patients in the Poly Womb of RSUD Ulin Banjarmasin are mostly in stages II and III, first had sexual intercourse at 20 years old, have multipara parity, and has a history of using hormonal contraception. Conclusion: Cervical cancer patients come at an advanced stage and cervical cancer is caused due to past life behavior.Key Word: Cervical Cancer

scholarly journals Prognostic Impact of Histopathology in Patients with Advanced Stage Cervical Carcinoma Treated with Radiotherapy

2019 ◽  
Vol 37 (4) ◽  
pp. 175-180
Author(s):  
Nasrin Hossain ◽  
Rahana Perveen ◽  
Mohammed Sharif Mahmud ◽  
Mohammed Kabirul Hassan
Keyword(s):  
Cervical Cancer ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cervical Carcinoma ◽  
Squamous Cell ◽  
Disease Free Survival ◽  
Advanced Stage ◽  
Free Survival ◽  
Histopathological Type ◽  
Disease Free

Introduction: Cervical cancer is the fourth most common cancer in women worldwidev . Most patients in developing countries including Bangladesh present at advanced stage. Histopathological types of cervical cancer influence the treatment outcome when treated by radiation therapy. Objective: To determine the disease free survival (DFS) in different histopathological types in advanced stage cervical carcinoma treated with radiotherapy. Methods: A prospective cohort study was conducted in Gynaecological oncology outpatient department (GOPD) of National institute of Cancer Research & Hospital (NICRH), Dhaka for one year from September’2016 to July’2017. Advanced stage (IIB-IVB) cervical cancer who completed radiation therapy and histopathological type either squamous cell carcinoma or adenocarcinoma of cervix were included in this study. Results: The median follow-up time was 1.82 years; range was 8 to 24 months. Average disease free survival (DFS) was 1.53years in squamous cell carcinoma (SSC) and 1.51 years in adenocarcinoma (ADC). Local recurrences was higher in adenocarcinoma group (62.5%) than squamous cell carcinoma (30.5%) & the difference was statistically significant (p = 0.001). Loco-regional recurrence and distal recurrence were also higher in ADC than SSC but results were not statistically significant (p=.345, p=.795). In multivariate analysis it was shown that histopathological type and stage of disease were found to be independently significant prognostic factors for DFS, hazard ratio were 1.766 (p=.018) and 2.173 (p=.006). Conclusion: Adenocarcinoma was a poor prognostic factor for patients with locally advanced cervical carcinoma. Advanced stage of disease was also significant predictor for disease free survival. J Bangladesh Coll Phys Surg 2019; 37(4): 175-180

Adenoid cystic carcinoma of the uterine cervix

2012 ◽  
Vol 153 (11) ◽  
pp. 435-437
Author(s):  
Péter Sámuel Nagy ◽  
Zoltán Tóth ◽  
Péter Gőcze ◽  
László Ádám
Keyword(s):  
Cervical Cancer ◽  
Adenoid Cystic Carcinoma ◽  
Rare Disease ◽  
Uterine Cervix ◽  
Poor Prognosis ◽  
Stage Iiib ◽  
Cancer Stage ◽  
Adenoid Cystic ◽  
Irradiation Therapy ◽  
History Of

This report presents the history of a 35-year-old patient with adenoid cystic cervical cancer stage IIIB. Adenoid cystic carcinoma of the uterine cervix is a rare disease with poor prognosis. Following irradiation therapy, the patient was declared tumor free, and 20 years after diagnosis and treatment, she has no pathological signs or symptoms. Orv. Hetil., 2012, 153, 435–437.

scholarly journals Mixed Adenocarcinoma and Squamous Cell Carcinoma of Duodenum: A Case Report and Review of the Literature

2017 ◽  
Vol 11 (2) ◽  
pp. 402-410 ◽  
Author(s):  
Muhammad Bader Hammami ◽  
Anuj Chhaparia ◽  
Jinhua Piao ◽  
Yihua Zhou ◽  
Christine Hachem ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Small Bowel ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Case Reports ◽  
Exploratory Laparotomy ◽  
Duodenal Mucosa ◽  
Management Guidelines ◽  
First Case ◽  
History Of

Despite being the largest part of the human gastrointestinal (GI) tract, the small intestine accounts for only 1–1.4% of all GI malignancies. Adenocarcinoma is the most common primary small bowel malignancy, with the most common site being the duodenum. On the other hand, squamous cell carcinoma (SCC) of the duodenum is extremely uncommon. We report the first case of mixed adenocarcinoma and SCC occurring in the third part of duodenum (D3). Our patient, a 64-year-old female with history of GERD, hypertension, and IDDM presented with 4 weeks of nausea, vomiting, and abdominal pain. Tomographic imaging of her abdomen demonstrated a distended stomach and a proximal duodenum with narrow caliber changes at the level of D3. An EGD revealed a tight stricture at D3 that could not be traversed. Stricture biopsies revealed duodenal mucosa with two small foci of SCC (positive for p63 and CK5/6) and adenocarcinoma (positive for CK7 and Moc31). Peritoneal metastases were detected on exploratory laparotomy, making the tumor surgically incurable. As she progressively declined and with worsening liver enzymes and general debility, she was not a candidate for chemotherapy and was eventually discharged on home hospice. Small bowel SCC/adenocarcinoma is an exceedingly uncommon cancer, making further case reports such as ours important to understand the nature of this entity and establish management guidelines.

scholarly journals 534 Takotsubo syndrome secondary to vaccination for SARS-CoV-2

2021 ◽  
Vol 23 (Supplement_G) ◽  
Author(s):  
Lorenzo Torselletti ◽  
Stronati Giulia ◽  
Francesca Corraducci ◽  
Sara Belleggia ◽  
Francesco Maiorino ◽  
...  
Keyword(s):  
Ejection Fraction ◽  
Case Reports ◽  
Partial Recovery ◽  
Takotsubo Syndrome ◽  
Wave Inversion ◽  
History Of ◽  
Post Menopausal ◽  
Significant Coronary Stenosis ◽  
Rule Out

Abstract Methods and results A 79-year-old woman, with a history of subclinical hypothyroidism, obesity and smoke presented to the Emergency Room with dyspnoea and cold sweating. She had undergone her first dose of COVID-19 Moderna mRna vaccination just four days prior to her admission. She showed elevated HS troponin and elevated BNP at her laboratory exams. Her 12-lead ECG showed T wave inversion in the antero-lateral leads and prolongued QTc. Her transthoracic echocardiogram showed severe ejection fraction reduction due to hypokinesia of the mid-apical segments of the anterior and lateral walls of the heart. The patient was then admitted to the Cardiology ward in order to perform a coronary angiography which sowed no significant coronary stenosis. She was started on appropriate medication and discharged after a six day in-hospital stay. At discharge she showed partial recovery of her ejection fraction (EF 44%). A cardiac magnetic resonance was performed after discharge which showed no late gadolinium enhancement. Such finding allowed us to rule out the diagnosis of myocarditis. Moreover at her 3-month follow-up her ejection fraction had recovered completely. We concluded for the diagnosis of Takotsubo Syndrome secondary to vaccination. Conclusions We presented a case of Takotsubo syndrome after vaccination with the Moderna vaccine for COVID-19. Two other similar case reports can be found in current medical literature. Female sex, post-menopausal age and the inevitable psychological stress derived by the pandemic and the vaccination may have triggered the condition.

scholarly journals Congenital heart defects and skeletal malformation syndrome with congenital hemiplegia

2021 ◽  
Vol 8 (4) ◽  
pp. 615
Author(s):  
Balakrishna Teli ◽  
Sneha Biradar
Keyword(s):  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Case Reports ◽  
Malformation Syndrome ◽  
Skeletal Malformation ◽  
Skeletal Malformations ◽  
History Of ◽  
Current Report ◽  
Rule Out

Congenital heart defects and skeletal malformation syndrome is very rare syndrome. Most of the patients had germline mutations in ABL1 gene. A 30-year-old gentleman presented with history of congenital heart disease (ventricular septal defect) and skeletal malformations which are typical of CHDSKM. Patient also had congenital hemiplegia which is rare in CHDSKMS. Patient also had lactose intolerance since childhood. Patients were evaluated thoroughly to rule out other causes. Current report is one of the rare case reports of CHDSKMS, only few case reports have been published till now.

Squamous Cell Carcinoma Antigen for Monitoring Cervical Cancer

1988 ◽  
Vol 3 (2) ◽  
pp. 87-94 ◽  
Author(s):  
P. Schmidt-Rhode ◽  
K.D. Schulz ◽  
G. Sturm ◽  
H. Häfner ◽  
H. Prinz ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Uterine Cervix ◽  
Primary Treatment ◽  
Pelvic Lymphadenectomy ◽  
Treatment Modalities ◽  
Early Rise ◽  
Scc Antigen

The tumour-associated antigen was determined in the plasma of patients with squamous cell carcinoma (SCC) of the uterine cervix by radioimmunoassay. Setting a limit of 2 ng/ml, levels were abnormal in 13.4% of healthy controls, in 14% of patients with carcinoma in situ and in 62% of patients with invasive cervical SCC. The incidence of elevated SCC antigen levels and the absolute antigen plasma concentration were dependent upon the tumour load, increasing significantly with advanced stage disease. Abnormal SCC antigen values in operable cervical cancer declined to normal within one week after radical hysterectomy with pelvic lymphadenectomy. In cases of radiotherapy antigen values took 4-6 weeks after the start of treatment to return to normal. The success of both treatment modalities was announced by an early rise in the SCC antigen in the initial phase of therapy, followed by normalisation. After successful primary treatment and a complete remission during further follow-up SCC antigen in plasma was only increased in 3.8% of the cases. Retrospective evaluations in ten patients with progressive disease showed the reappearance of abnormal SCC titers and further increase preceeding the clinically detectable relapse or progression, with a median interval of 8 weeks. The present study indicates that SCC antigen determination is not useful for the early diagnosis of cervical cancer, but it is a potential means for monitoring the efficacy of individual anticancer therapy of SCC of the uterine cervix and for detecting recurrent disease.

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