scholarly journals Spontaneous Pathological Complete Regression of Hepatocellular Carcinoma

2018 ◽  
Vol 12 (3) ◽  
pp. 653-659
Author(s):  
Tomohiko Taniai ◽  
Yoshihiro Shirai ◽  
Hiroaki Shiba ◽  
Taro Sakamoto ◽  
Kenei Furukawa ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatic Resection ◽  
Spontaneous Regression ◽  
Elevated Serum ◽  
Normal Serum ◽  
Pathological Examination ◽  
Complete Regression ◽  
Resonance Imaging ◽  
The Third ◽  
Serum Alpha Fetoprotein

Several possible mechanisms for spontaneous regression of hepatocellular carcinoma (HCC) have been reported. Spontaneous complete regression of HCC is extremely rare. We herein report a case of spontaneous pathological complete regression of HCC following decrement of elevated serum alpha-fetoprotein (AFP). The serum AFP of a 74-year-old man who underwent hepatic resection for HCC twice increased up to 7,529 ng/mL and then spontaneously decreased to 404 ng/mL in 2 months. Computed tomography, magnetic resonance imaging, and angiography revealed a liver tumor in segment 7 without early enhancement. With a diagnosis of recurrent HCC, partial hepatic resection was performed. The resected specimens revealed no HCC macroscopically, and pathological examination revealed only a small area with cell dysplasia. The patient remains well with normal serum AFP and protein induced by vitamin K absence or antagonist-II (PIVKA-II) levels for 29 months after the third hepatic resection without recurrence of HCC. We describe a case of spontaneous pathological complete regression of HCC following decrement of elevated serum AFP. Further studies are needed to identify the mechanism(s) of spontaneous regression of HCC.

scholarly journals Postpartum Regression of a Presumed Cavernous Meningioma

2016 ◽  
Vol 2016 ◽  
pp. 1-3
Author(s):  
See Yung Phang ◽  
Peter Whitfield
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Caucasian Woman ◽  
Complete Regression ◽  
Resonance Imaging ◽  
Third Trimester ◽  
Mri Scan ◽  
The Third ◽  
Cavernous Sinus Meningioma ◽  
Magnetic Resonance Imaging Mri

Meningiomas are known to be more common in females than males. They are also known in rare cases to grow in size during pregnancy, which can complicate its management. We describe a 31-year-old Caucasian woman who presented with blurring of her vision and diplopia during the third trimester of her pregnancy. Magnetic resonance imaging (MRI) showed a small left cavernous sinus meningioma. The patient was treated conservatively until her uncomplicated delivery. A postpartum MRI scan showed complete regression of the suspected meningioma. Currently the patient is contemplating a further pregnancy.

Detection of hepatocellular carcinoma with a new alpha-fetoprotein antibody imaging kit.

1997 ◽  
Vol 15 (7) ◽  
pp. 2683-2690 ◽  
Author(s):  
S Dresel ◽  
C M Kirsch ◽  
K Tatsch ◽  
R Zachoval ◽  
K Hahn ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Hepatocellular Carcinoma ◽  
Metastatic Disease ◽  
False Negative ◽  
Photon Emission ◽  
Elevated Serum ◽  
Normal Serum ◽  
Alpha Fetoprotein ◽  
Emission Computed Tomography ◽  
Antibody Imaging

PURPOSE The aim of this phase II study was to assess the clinical utility and safety of AFP-Scan (Immunomedics, Inc, Morris Plains, NJ), a technetium-99m (99mTc)-labeled anti-alpha-fetoprotein (AFP) Fab' imaging kit, in the evaluation of hepatocellular carcinoma (HCC), in comparison to computed tomography (CT). PATIENTS AND METHODS Twenty-five consecutive patients with a history of HCC were examined by planar and single-photon emission computed tomography (SPECT) imaging at 6 and 24 hours after intravenous (I.V.) injection of 1 mg AFP-Scan labeled with 925 MBq 99mTc. RESULTS In 20 patients, there was a specific binding of the Fab' antibody to the tumor, whereas in four patients who presented with elevated serum AFP levels, no specific targeting was found and no malignant lesions were evident by CT or biopsy. One patient was diagnosed as false-negative by AFP-Scan. In five of six patients with normal serum AFP levels, focal uptake was demonstrated. In one case, metastatic disease in the lower abdomen was found. In all patients, diagnostically relevant information was provided by the 24-hour antibody images, especially with SPECT. Comparing AFP-Scan versus CT, the former showed a higher sensitivity (95% v 63%) and specificity (67% v 17%), with an overall accuracy of 88% versus 52% for AFP-Scan versus CT, even in patients with normal serum AFP titers. No adverse reactions or human antimouse antibody (HAMA) elevations were found in any of the patients. CONCLUSIONS AFP-Scan appears to be a promising new antibody imaging kit for the disclosure of sites of HCC and should aid in the management of these patients by revealing primary, recurrent, and metastatic disease with a single imaging modality.

scholarly journals Spontaneous Regression of Advanced Hepatocellular Carcinoma

2020 ◽  
Vol 14 (3) ◽  
pp. 491-496
Author(s):  
Dhiraj J. Sonbare ◽  
Rupal Bandi ◽  
Vivek Sharma ◽  
Thomas Cacciarelli ◽  
Obaid S. Shaikh
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Invasion ◽  
Spontaneous Regression ◽  
Tumor Regression ◽  
Complete Regression ◽  
Advanced Hepatocellular Carcinoma ◽  
Specific Therapy ◽  
Therapeutic Implications ◽  
Spontaneous Tumor Regression ◽  
Related Mortality

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality. The tumor carries poor prognosis with curative therapeutic options limited to surgical resection, tumor ablation, and liver transplantation. Rarely, there is spontaneous regression of the tumor. We describe the case of a 74-year-old male with cirrhosis from non-alcoholic steatohepatitis who developed advanced HCC that was associated with tumor invasion of the portal vein and marked elevation of serum alfa-fetoprotein level. The patient received no cancer-specific therapy. However, 1 year after the initial diagnosis, he was noted to have complete regression of the tumor. In this report, we discuss possible mechanisms of spontaneous tumor regression and its therapeutic implications.

scholarly journals Unresectable Ectopic Hepatocellular Carcinoma Treated with Sorafenib

2020 ◽  
Vol 14 (1) ◽  
pp. 226-233 ◽  
Author(s):  
Yi-Ling Ko ◽  
Kazuhide Takata ◽  
Takashi Tanaka ◽  
Jun Ohishi ◽  
Morishige Takeshita ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Laboratory Tests ◽  
Diagnostic Laparoscopy ◽  
Kinase Inhibitor ◽  
Elevated Serum ◽  
Lower Abdominal Pain ◽  
Similar Morphology ◽  
Serum Alpha Fetoprotein ◽  
Rare Malignancy ◽  
Enhanced Computed Tomography

Ectopic hepatocellular carcinoma (HCC) is a rare malignancy, which manifests similar morphology and immunohistochemistry to intrahepatic HCC. Herein, we report a case of ectopic HCC in a 73-year-old male. The patient presented to our hospital with gradually progressing right lower abdominal pain, and enhanced computed tomography revealed multiple nodules in the peritoneum without intrahepatic mass. A diagnostic laparoscopy was performed, and the final pathology result confirmed that it was HCC. Additional laboratory tests showed elevated serum alpha-fetoprotein and protein induced by vitamin K absence-II (PIVKA-II) levels, suggesting our diagnosis. The patient received sorafenib, a tyrosine kinase inhibitor (TKI), for unresectable ectopic HCC. However, the tumor progressed, and because of tarry stools and hemorrhagic anemia, sorafenib was ceased after 7 months of therapy. One month after the cessation of sorafenib, the PIVKA-II level increased abruptly, and the patient died 1 year after diagnosis. The effective treatment for unresectable ectopic HCC is still unknown. Additional cases should be accumulated to determine the effect of TKI on ectopic HCC.

scholarly journals Spontaneous Regression of Hepatocellular Carcinoma: Its Imaging Course Leading to Complete Disappearance

2015 ◽  
Vol 8 (1) ◽  
pp. 94-100 ◽  
Author(s):  
Akihiro Okano ◽  
Masaya Ohana
Keyword(s):  
Hepatocellular Carcinoma ◽  
Serum Level ◽  
Spontaneous Regression ◽  
Clinical Course ◽  
Short Interval ◽  
Elevated Serum ◽  
Complete Disappearance ◽  
B Virus ◽  
Hepatic Angiography ◽  
The Right

Spontaneous regression of hepatocellular carcinoma (HCC) is a rare phenomenon. We followed a detailed clinical course of a spontaneous and complete disappearance of HCC during a short interval. A 73-year-old man with hepatitis B virus infection presented with a 15-mm mass in the right anterior superior segment of the liver. The mass was diagnosed as HCC by imaging findings. We found an elevated serum α-fetoprotein (AFP) level of 748 ng/ml. The tumor regressed to 6 mm on imaging examination, and the AFP serum level decreased to 87.8 ng/ml 1 month after the diagnostic hepatic angiography. Therefore, the patient was followed up without any treatment for HCC. The tumor disappeared 5 months later when the AFP serum level was 5.0 ng/ml. The diagnostic hepatic angiography might have had some effect on the spontaneous regression of HCC in the present case.

scholarly journals Synchronous Double Primary Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma: A Case Report and Review of the Literature

2021 ◽  
Author(s):  
Meng-Meng Qu ◽  
Yuan-Hui Zhu ◽  
Yi-Xiang Li ◽  
Zhi-fan Li ◽  
Jin-Kui Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Hepatic Resection ◽  
Intrahepatic Cholangiocarcinoma ◽  
Histopathological Examination ◽  
Primary Hepatocellular Carcinoma ◽  
Pathological Examination ◽  
B Virus ◽  
Poorly Differentiated

Abstract Background: Synchronous double primary hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) (sdpHCC-ICC) located separately within a single liver is extremely rare. The purpose of this study is to investigate the clinical, imaging, pathological characteristics and prognosis of patients with sdpHCC-ICC, in order to enhance our understanding of the disease and improve diagnostic and therapeutic effect.Case presentation: A 49-year-old female patient with obvious liver cirrhosis, who carried hepatitis B virus, was admitted to our hospital for physical examination. The level of α-fetoprotein (AFP) and carbohydrate antigen 19-9 (CA19-9) was found to be elevated. Abdominal ultrasonography and enhanced computed tomography revealed two solid masses located in segments (S) 4 and 6 of the liver, with malignant behaviors. The preoperation diagnosis was multiple primary hepatocellular carcinomas. We performed hepatic resection of both segments. The resected specimens revealed that the tumors in segments 4 and 6 were well-defined lesions of 5.0 cm and 2.5cm, respectively. Histopathological examination confirmed that the tumor of the 4th segment to be moderately and poorly differentiated ICC, and that the tumor of the 6th segment to be poorly differentiated HCC. Immunohistochemically, the ICC in S4 was positive for CK19 and negative for Heppar-1, while the HCC in S6 was positive for Heppar-1 and negative for CK19. Unfortunately，metastasis and recurrence of multiple organs and lymph nodes were observed only 3 months later.Conclusions: The clinical characteristics of sdpHCC-ICC are usually atypical. It is of difficulty to make an accurate preoperative diagnosis. Hepatitis B virus (HBV) and hepatitis C virus (HCV) infection were both the independent risk factor to the development of sdpHCC-ICC. In patients with chronic liver disease, careful observation with imaging examination should be necessary. Tumor markers may be valuable to the diagnosis of it. The definite diagnosis depends on pathological examination. Hepatic resection may be the preferred and most effective treatment. The prognosis of synchronous occurrence of double hepatic cancers was poorer than for either HCC or ICC, and the origin of it needs further study.

Lymphocytic Adenohypophysitis: Clinical, Radiological, and Magnetic Resonance Imaging Characterization

Neurosurgery ◽  
1988 ◽  
Vol 22 (5) ◽  
pp. 937-941 ◽  
Author(s):  
Steven N. Levine ◽  
Edward C. Benzel ◽  
Marjorie R. Fowler ◽  
John V. Shroyer ◽  
Mansour Mirfakhraee
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Plasma Cells ◽  
Elevated Serum ◽  
Pathological Examination ◽  
Serum Prolactin ◽  
Resonance Imaging ◽  
Pituitary Mass ◽  
First Case ◽  
Lymphocytic Adenohypophysitis

Abstract Lymphocytic adenohypophysitis is a rare nonneoplastic cause of a pituitary mass. We report the case of an 18-year-old woman who presented with complaints of headaches and visual disturbances after an otherwise uncomplicated pregnancy and delivery. She had an elevated serum prolactin level and a pituitary mass visualized by magnetic resonance imaging (MRI). The tissue removed by transsphenoidal resection was an inflammatory mass composed of lymphocytes, plasma cells, and moderate fibrosis surrounding islands of hyperplastic lactotrophs. This is the first case of lymphocytic adenohypophysitis visualized by MRI. As in this case, lymphocytic adenohypophysitis is frequently confused with a prolactin-secreting pituitary tumor before operation and pathological examination of the tissue. The clinical characteristics and radiological features of and an approach to managing patients with lymphocytic adenohypophysitis are reviewed and discussed.

scholarly journals Usefulness of Circulating Methylated p16 as a Noninvasive Molecular Biomarker for Hepatitis C-Related Hepatocellular Carcinoma with Normal Serum Alpha-Fetoprotein Levels

2020 ◽  
Vol Volume 13 ◽  
pp. 147-155
Author(s):  
Wael Abd Elgwad Elsewify ◽  
Elham Ahmed Hassan ◽  
Mohamed A Mekky ◽  
Abeer Sharaf El-Din Abd El-Rehim ◽  
Zain El-Abdeen Ahmed Sayed ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis C ◽  
Normal Serum ◽  
Alpha Fetoprotein ◽  
Molecular Biomarker ◽  
Serum Alpha Fetoprotein
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