Clinical characteristics of hepatocellular carcinoma patients with normal serum alpha-fetoprotein level: A study of 112 consecutive cases

2017 ◽  
Vol 14 (5) ◽  
pp. e336-e340
Author(s):  
Li Li ◽  
Jinglong Chen ◽  
Weiran Xu ◽  
Xiaosheng Ding ◽  
Xiangyi Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Characteristics ◽  
Normal Serum ◽  
Alpha Fetoprotein ◽  
Serum Alpha Fetoprotein

scholarly journals Usefulness of Circulating Methylated p16 as a Noninvasive Molecular Biomarker for Hepatitis C-Related Hepatocellular Carcinoma with Normal Serum Alpha-Fetoprotein Levels

2020 ◽  
Vol Volume 13 ◽  
pp. 147-155
Author(s):  
Wael Abd Elgwad Elsewify ◽  
Elham Ahmed Hassan ◽  
Mohamed A Mekky ◽  
Abeer Sharaf El-Din Abd El-Rehim ◽  
Zain El-Abdeen Ahmed Sayed ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis C ◽  
Normal Serum ◽  
Alpha Fetoprotein ◽  
Molecular Biomarker ◽  
Serum Alpha Fetoprotein

Decreasing trend of serum alpha-fetoprotein level in hepatocellular carcinoma

2021 ◽  
Author(s):  
Aarshi Vipani ◽  
Marie Lauzon ◽  
Michael Luu ◽  
Lewis R. Roberts ◽  
Amit G. Singal ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Alpha Fetoprotein ◽  
Serum Alpha Fetoprotein

Detection of hepatocellular carcinoma with a new alpha-fetoprotein antibody imaging kit.

1997 ◽  
Vol 15 (7) ◽  
pp. 2683-2690 ◽  
Author(s):  
S Dresel ◽  
C M Kirsch ◽  
K Tatsch ◽  
R Zachoval ◽  
K Hahn ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Hepatocellular Carcinoma ◽  
Metastatic Disease ◽  
False Negative ◽  
Photon Emission ◽  
Elevated Serum ◽  
Normal Serum ◽  
Alpha Fetoprotein ◽  
Emission Computed Tomography ◽  
Antibody Imaging

PURPOSE The aim of this phase II study was to assess the clinical utility and safety of AFP-Scan (Immunomedics, Inc, Morris Plains, NJ), a technetium-99m (99mTc)-labeled anti-alpha-fetoprotein (AFP) Fab' imaging kit, in the evaluation of hepatocellular carcinoma (HCC), in comparison to computed tomography (CT). PATIENTS AND METHODS Twenty-five consecutive patients with a history of HCC were examined by planar and single-photon emission computed tomography (SPECT) imaging at 6 and 24 hours after intravenous (I.V.) injection of 1 mg AFP-Scan labeled with 925 MBq 99mTc. RESULTS In 20 patients, there was a specific binding of the Fab' antibody to the tumor, whereas in four patients who presented with elevated serum AFP levels, no specific targeting was found and no malignant lesions were evident by CT or biopsy. One patient was diagnosed as false-negative by AFP-Scan. In five of six patients with normal serum AFP levels, focal uptake was demonstrated. In one case, metastatic disease in the lower abdomen was found. In all patients, diagnostically relevant information was provided by the 24-hour antibody images, especially with SPECT. Comparing AFP-Scan versus CT, the former showed a higher sensitivity (95% v 63%) and specificity (67% v 17%), with an overall accuracy of 88% versus 52% for AFP-Scan versus CT, even in patients with normal serum AFP titers. No adverse reactions or human antimouse antibody (HAMA) elevations were found in any of the patients. CONCLUSIONS AFP-Scan appears to be a promising new antibody imaging kit for the disclosure of sites of HCC and should aid in the management of these patients by revealing primary, recurrent, and metastatic disease with a single imaging modality.

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