scholarly journals Spontaneous Regression of Hepatocellular Carcinoma: Its Imaging Course Leading to Complete Disappearance

2015 ◽  
Vol 8 (1) ◽  
pp. 94-100 ◽  
Author(s):  
Akihiro Okano ◽  
Masaya Ohana
Keyword(s):  
Hepatocellular Carcinoma ◽  
Serum Level ◽  
Spontaneous Regression ◽  
Clinical Course ◽  
Short Interval ◽  
Elevated Serum ◽  
Complete Disappearance ◽  
B Virus ◽  
Hepatic Angiography ◽  
The Right

Spontaneous regression of hepatocellular carcinoma (HCC) is a rare phenomenon. We followed a detailed clinical course of a spontaneous and complete disappearance of HCC during a short interval. A 73-year-old man with hepatitis B virus infection presented with a 15-mm mass in the right anterior superior segment of the liver. The mass was diagnosed as HCC by imaging findings. We found an elevated serum α-fetoprotein (AFP) level of 748 ng/ml. The tumor regressed to 6 mm on imaging examination, and the AFP serum level decreased to 87.8 ng/ml 1 month after the diagnostic hepatic angiography. Therefore, the patient was followed up without any treatment for HCC. The tumor disappeared 5 months later when the AFP serum level was 5.0 ng/ml. The diagnostic hepatic angiography might have had some effect on the spontaneous regression of HCC in the present case.

Elevated serum level of glycolipid sulfotransferase in patients with hepatocellular carcinoma

1991 ◽  
Vol 59 (1) ◽  
pp. 19-24 ◽  
Author(s):  
S. Gasa ◽  
M-T. Casl ◽  
T. Jin ◽  
K. Kamio ◽  
Y. Uehara ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Serum Level ◽  
Elevated Serum ◽  
Elevated Serum Level

scholarly journals The changing epidemiology of hepatocellular carcinoma in Asia versus United States and Europe

2017 ◽  
Vol 3 (s1) ◽  
pp. 51 ◽  
Author(s):  
Jasmanda Wu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B ◽  
Clinical Course ◽  
Immunization Program ◽  
Alcoholic Fatty Liver ◽  
Aggressive Form ◽  
B Virus ◽  
Public Health Challenge ◽  
Geographic Regions ◽  
Alcoholic Fatty Liver Disease

<p>Hepatocellular carcinoma (HCC) is a major disease worldwide. There were 782,000 estimated new cases globally<br />in 2012 with the majority (76%) occurring in Asia, especially China. Although the etiologies are similar, the prevalence of<br />each HCC risk factor varies in different geographic regions. In China, hepatitis B virus (HBV) infection is the major cause<br />of HCC, whereas in Japan, US and Europe, hepatitis C virus (HCV) infection predominates. With the epidemic of obesity<br />and diabetes, non-alcoholic fatty liver disease (NAFLD), especially its more aggressive form non-alcoholic steatohepatitis<br />(NASH), has now become a major contributor to HCC. It is anticipated that NAFLD/NASH is likely to overtake viral<br />hepatitis as the leading contributor to HCC in the future. Prior success in reducing HCC cases through hepatitis B<br />immunization program and effective HBV treatments is likely to be offset by rising significance of NASH-associated HCC.<br />In view of this, appropriate measures such as aggressive monitoring clinical course and prognoses of patients with HCC<br />from NASH, studying pathogenesis and mechanism by which NASH promotes HCC, and developing novel intervention and<br />treatment strategy for these patients would be important to address this important public health challenge.</p>

scholarly journals Detection of early-stage hepatocellular carcinoma in asymptomatic HBsAg-seropositive individuals by liquid biopsy

2019 ◽  
Vol 116 (13) ◽  
pp. 6308-6312 ◽  
Author(s):  
Chunfeng Qu ◽  
Yuting Wang ◽  
Pei Wang ◽  
Kun Chen ◽  
Minjie Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liquid Biopsy ◽  
Early Stage ◽  
Elevated Serum ◽  
Normal Liver ◽  
Protein Markers ◽  
Liquid Biopsies ◽  
B Virus ◽  
Asymptomatic Individuals

Liquid biopsies, based on cell free DNA (cfDNA) and proteins, have shown the potential to detect early stage cancers of diverse tissue types. However, most of these studies were retrospective, using individuals previously diagnosed with cancer as cases and healthy individuals as controls. Here, we developed a liquid biopsy assay, named the hepatocellular carcinoma screen (HCCscreen), to identify HCC from the surface antigen of hepatitis B virus (HBsAg) positive asymptomatic individuals in the community population. The training cohort consisted of individuals who had liver nodules and/or elevated serum α-fetoprotein (AFP) levels, and the assay robustly separated those with HCC from those who were non-HCC with a sensitivity of 85% and a specificity of 93%. We further applied this assay to 331 individuals with normal liver ultrasonography and serum AFP levels. A total of 24 positive cases were identified, and a clinical follow-up for 6–8 mo confirmed four had developed HCC. No HCC cases were diagnosed from the 307 test-negative individuals in the follow-up during the same timescale. Thus, the assay showed 100% sensitivity, 94% specificity, and 17% positive predictive value in the validation cohort. Notably, each of the four HCC cases was at the early stage (<3 cm) when diagnosed. Our study provides evidence that the use of combined detection of cfDNA alterations and protein markers is a feasible approach to identify early stage HCC from asymptomatic community populations with unknown HCC status.

scholarly journals Spontaneous Pathological Complete Regression of Hepatocellular Carcinoma

2018 ◽  
Vol 12 (3) ◽  
pp. 653-659
Author(s):  
Tomohiko Taniai ◽  
Yoshihiro Shirai ◽  
Hiroaki Shiba ◽  
Taro Sakamoto ◽  
Kenei Furukawa ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatic Resection ◽  
Spontaneous Regression ◽  
Elevated Serum ◽  
Normal Serum ◽  
Pathological Examination ◽  
Complete Regression ◽  
Resonance Imaging ◽  
The Third ◽  
Serum Alpha Fetoprotein

Several possible mechanisms for spontaneous regression of hepatocellular carcinoma (HCC) have been reported. Spontaneous complete regression of HCC is extremely rare. We herein report a case of spontaneous pathological complete regression of HCC following decrement of elevated serum alpha-fetoprotein (AFP). The serum AFP of a 74-year-old man who underwent hepatic resection for HCC twice increased up to 7,529 ng/mL and then spontaneously decreased to 404 ng/mL in 2 months. Computed tomography, magnetic resonance imaging, and angiography revealed a liver tumor in segment 7 without early enhancement. With a diagnosis of recurrent HCC, partial hepatic resection was performed. The resected specimens revealed no HCC macroscopically, and pathological examination revealed only a small area with cell dysplasia. The patient remains well with normal serum AFP and protein induced by vitamin K absence or antagonist-II (PIVKA-II) levels for 29 months after the third hepatic resection without recurrence of HCC. We describe a case of spontaneous pathological complete regression of HCC following decrement of elevated serum AFP. Further studies are needed to identify the mechanism(s) of spontaneous regression of HCC.

Role of environmental factors in the etiology of hepatocellular carcinoma

2010 ◽  
Vol 151 (28) ◽  
pp. 1132-1136 ◽  
Author(s):  
István Tornai
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Environmental Factors ◽  
Hepatitis B ◽  
Hepatitis A ◽  
Virus Hepatitis ◽  
B Virus

A krónikus vírushepatitisek jelentik ma a legismertebb okokat a hepatocellularis carcinoma (HCC) kialakulásában. A krónikus B- és C-vírus-hepatitis a májrákok körülbelül 40-50%-át okozza. A nyugati típusú társadalmakban a HCC előfordulása folyamatosan növekvő tendenciát mutat. Az alkohol számít a környezeti tényezők közül a legfontosabbnak, bár az alkoholfogyasztás a legtöbb országban csökken. Ez aláhúzza az egyéb környezeti tényezők fontosságát is. Az elfogyasztott alkoholmennyiséggel egyenes arányban növekszik a cirrhosis és a következményes HCC gyakorisága nőkben és férfiakban egyaránt. A kémiai anyagok közül a legismertebb a Kínában és Afrikában elterjedt aflatoxin, amely a gabonaféléket szennyező mycotoxin. Hasonló területeken endémiás, mint a hepatitis B-vírus, együtt szinergista hatást fejtenek ki. A dohányzás is egyértelműen bizonyított hepatocarcinogen hatással rendelkezik. Ez is jelentősen fokozódik, ha alkoholfogyasztással vagy vírushepatitisszel társul. Társadalmilag talán a legfontosabb az elhízás, a következményes nem alkoholos zsírmáj, illetve steatohepatitis és a 2-es típusú cukorbetegség, amelyek prevalenciája egyre fokozódik. Feltehetően ezek állnak a növekvő HCC-gyakoriság hátterében. Az inzulinrezisztencia és az oxidatív stressz képezik a legfontosabb patogenetikai lépéseket a májsejtkárosodásban. További fontos rizikótényező az orális fogamzásgátlók elterjedt használata. Egyes foglalkozások esetén a tartós szervesoldószer-expozíció is növeli a HCC rizikóját. Védelmet jelenthetnek az antioxidánsok, a szelén, a gyógyszerek közül a statinok és a feketekávé-fogyasztás.

Giant right coronary artery aneurysm

2020 ◽  
Vol 28 ◽  
pp. 1-3
Author(s):  
Alexandre Bonfim ◽  
Ronald Souza ◽  
Sérgio Beraldo ◽  
Frederico Nunes ◽  
Daniel Beraldo
Keyword(s):  
Coronary Artery ◽  
Right Coronary Artery ◽  
Coronary Artery Aneurysm ◽  
Clinical Course ◽  
Artery Aneurysm ◽  
Giant Aneurysm ◽  
Coronary Artery Aneurysms ◽  
History Of ◽  
Artery Disease ◽  
The Right

Right coronary artery aneurysms are rare and may result from severe coronary disease, with few cases described in the literature. Mortality is high, and therapy is still controversial. We report the case of a 72-year-old woman with arterial hypertension, and a family history of coronary artery disease, who evolved for 2 months with episodes of palpitations and dyspnea on moderate exertion. During the evaluation, a giant aneurysm was found in the proximal third of the right coronary artery. The patient underwent surgical treatment with grafting of the radial artery to the right coronary artery and ligation of the aneurysmal sac, with good clinical course.

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