Possible Role of Hydrolysis Products of the Dietary Components in the Mechanisms of the Exocrine Pancreatic Adaptation to the Diet

2015 ◽  
pp. 132-144 ◽  
Author(s):  
Tristan Corring
Keyword(s):  
Hydrolysis Products ◽  
Dietary Components

scholarly journals The Role of Resolvins, Protectins and Marensins in Non-Alcoholic Fatty Liver Disease (NAFLD)

Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 937
Author(s):  
Dominika Maciejewska-Markiewicz ◽  
Ewa Stachowska ◽  
Viktoria Hawryłkowicz ◽  
Laura Stachowska ◽  
Piotr Prowans
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Liver Lipid ◽  
Dietary Factors ◽  
Alcoholic Fatty Liver ◽  
Dietary Components ◽  
Alcoholic Fatty Liver Disease ◽  
Docosahexaenoic Acids

Increased triacylglycerols’ (TAG) synthesis, insulin resistance, and prolonged liver lipid storage might lead to the development of non-alcoholic fatty liver disease (NAFLD). Global prevalence of NAFLD has been estimated to be around 25%, with gradual elevation of this ratio along with the increased content of adipose tissue in a body. The initial stages of NAFLD may be reversible, but the exposition to pathological factors should be limited. As dietary factors greatly influence various disease development, scientists try to find dietary components, helping to alleviate the steatosis. These components include n-3 polyunsaturated (PUFA) fatty acids, especially eicosapentaenoic acid (EPA) and docosahexaenoic acids (DHA). This review focused on the role of resolvins, protectins and merensins in NAFLD.

scholarly journals Inflammation and metabolism: the role of adiposity in sarcopenic obesity

2020 ◽  
Vol 79 (4) ◽  
pp. 435-447
Author(s):  
G. M. Lynch ◽  
C. H. Murphy ◽  
E. de Marco Castro ◽  
H. M. Roche
Keyword(s):  
Nutritional Status ◽  
Sarcopenic Obesity ◽  
Obesity Risk ◽  
Dietary Interventions ◽  
Double Burden ◽  
Metabolic Inflammation ◽  
Fat Composition ◽  
Dietary Components ◽  
Potential Impact

Sarcopenic obesity is characterised by the double burden of diminished skeletal muscle mass and the presence of excess adiposity. From a mechanistic perspective, both obesity and sarcopenia are associated with sub-acute, chronic pro-inflammatory states that impede metabolic processes, disrupting adipose and skeletal functionality, which may potentiate disease. Recent evidence suggests that there is an important cross-talk between metabolism and inflammation, which has shifted focus upon metabolic-inflammation as a key emerging biological interaction. Dietary intake, physical activity and nutritional status are important environmental factors that may modulate metabolic-inflammation. This paradigm will be discussed within the context of sarcopenic obesity risk. There is a paucity of data in relation to the nature and the extent to which nutritional status affects metabolic-inflammation in sarcopenic obesity. Research suggests that there may be scope for the modulation of sarcopenic obesity with alterations in diet. The potential impact of increasing protein consumption and reconfiguration of dietary fat composition in human dietary interventions are evaluated. This review will explore emerging data with respect to if and how different dietary components may modulate metabolic-inflammation, particularly with respect to adiposity, within the context of sarcopenic obesity.

Role of the Microbiome in Mediating Health Effects of Dietary Components

2020 ◽  
Vol 68 (46) ◽  
pp. 12820-12835 ◽  
Author(s):  
Lingxiao Gong ◽  
Tingting Wen ◽  
Jing Wang
Keyword(s):  
Health Effects ◽  
Dietary Components

scholarly journals The role of meat in the expression of rheumatoid arthritis

2000 ◽  
Vol 84 (5) ◽  
pp. 589-595 ◽  
Author(s):  
William B. Grant
Keyword(s):  
Rheumatoid Arthritis ◽  
Short Review ◽  
Ecological Approach ◽  
Statistical Association ◽  
Prevalence Data ◽  
Statistical Correlations ◽  
Period 2 ◽  
Dietary Components ◽  
Synovial Tissues

Rheumatoid arthritis (RA) is characterized by inflammation of the synovial tissues in the joints. A number of papers related to dietary components that are associated with this inflammation are reviewed. In addition, the ecological approach is used to study the links between diet and RA. Multi-country data for prevalence of RA for females from eight and fifteen countries were compared statistically with components of national dietary supply. Fat from meat and offal for the period 2 years before the prevalence data was found to have the highest statistical association with the prevalence of RA (r2 0·877, P<0·001 for eight countries). The statistical correlations for meat and offal were almost as high as those for their fat. Similar correlations were found for temporal changes in indices of effects of RA in several European countries between 1968 and 1978 as more meat was added to the national diets, although the correlations were higher for meat than for fat. It is hypothesized that meat and offal may be a major factor contributing to the inflammation in RA. In the present short review, the author examines some of the data that associate meat consumption with RA and the possible factors, e.g. fat, Fe and nitrite, which may contribute to the inflammation.

scholarly journals Development of Salmonellosis as Affected by Bioactive Food Compounds

2019 ◽  
Vol 7 (9) ◽  
pp. 364 ◽  
Author(s):  
Ajay Kumar ◽  
Abimbola Allison ◽  
Monica Henry ◽  
Anita Scales ◽  
Aliyar Cyrus Fouladkhah
Keyword(s):  
Public Health ◽  
Clinical Studies ◽  
Randomized Clinical Trials ◽  
Financial Burden ◽  
Epidemiological Studies ◽  
Public Health Burden ◽  
Dietary Components ◽  
Underlying Mechanisms ◽  
Evidence Based Guideline

Infections caused by Salmonella serovars are the leading cause of foodborne hospitalizations and deaths in Americans, extensively prevalent worldwide, and pose a considerable financial burden on public health infrastructure and private manufacturing. While a comprehensive review is lacking for delineating the role of dietary components on prevention of Salmonellosis, evidence for the role of diet for preventing the infection and management of Salmonellosis symptoms is increasing. The current study is an evaluation of preclinical and clinical studies and their underlying mechanisms to elaborate the efficacy of bioactive dietary components for augmenting the prevention of Salmonella infection. Studies investigating dietary components such as fibers, fatty acids, amino acids, vitamins, minerals, phenolic compounds, and probiotics exhibited efficacy of dietary compounds against Salmonellosis through manipulation of host bile acids, mucin, epithelial barrier, innate and adaptive immunity and gut microbiota as well as impacting the cellular signaling cascades of the pathogen. Pre-clinical studies investigating synergism and/or antagonistic activities of various bioactive compounds, additional randomized clinical trials, if not curtailed by lack of equipoise and ethical concerns, and well-planned epidemiological studies could augment the development of a validated and evidence-based guideline for mitigating the public health burden of human Salmonellosis through dietary compounds.

scholarly journals Genes and Diet in the Prevention of Chronic Diseases in Future Generations

2020 ◽  
Vol 21 (7) ◽  
pp. 2633 ◽  
Author(s):  
Marica Franzago ◽  
Daniele Santurbano ◽  
Ester Vitacolonna ◽  
Liborio Stuppia
Keyword(s):  
Human Health ◽  
Dietary Intervention ◽  
Nutrient Requirements ◽  
Metabolic Disturbances ◽  
Transgenerational Transmission ◽  
Key Factor ◽  
Dietary Components ◽  
Diabetes Gestational

Nutrition is a modifiable key factor that is able to interact with both the genome and epigenome to influence human health and fertility. In particular, specific genetic variants can influence the response to dietary components and nutrient requirements, and conversely, the diet itself is able to modulate gene expression. In this context and the era of precision medicine, nutrigenetic and nutrigenomic studies offer significant opportunities to improve the prevention of metabolic disturbances, such as Type 2 diabetes, gestational diabetes, hypertension, and cardiovascular diseases, even with transgenerational effects. The present review takes into account the interactions between diet, genes and human health, and provides an overview of the role of nutrigenetics, nutrigenomics and epigenetics in the prevention of non-communicable diseases. Moreover, we focus our attention on the mechanism of intergenerational or transgenerational transmission of the susceptibility to metabolic disturbances, and underline that the reversibility of epigenetic modifications through dietary intervention could counteract perturbations induced by lifestyle and environmental factors.

scholarly journals Maternal diet quality before pregnancy and risk of childhood leukaemia

2016 ◽  
Vol 116 (8) ◽  
pp. 1469-1478 ◽  
Author(s):  
Amanda W. Singer ◽  
Suzan L. Carmichael ◽  
Steve Selvin ◽  
Cecilia Fu ◽  
Gladys Block ◽  
...  
Keyword(s):  
Diet Quality ◽  
Maternal Nutrition ◽  
Case Control Study ◽  
Maternal Diet ◽  
Conditional Logistic Regression ◽  
Childhood Leukaemia ◽  
Dietary Components ◽  
The Relationship ◽  
Control Study

AbstractPrevious studies on maternal nutrition and childhood leukaemia risk have focused on the role of specific nutrients such as folate and have not considered broader measures of diet quality, which may better capture intake of diverse nutrients known to impact fetal development. We examined the relationship between maternal diet quality before pregnancy, as summarised by a diet quality index, and risk of childhood acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML) in a case–control study in California. Dietary intake in the year before pregnancy was assessed using FFQ in 681 ALL cases, 103 AML cases and 1076 matched controls. Conditional logistic regression was used to estimate OR and 95 % CI for diet quality continuous score and quartiles (Q1–Q4). Higher maternal diet quality score was associated with reduced risk of ALL (OR 0·66; 95 % CI 0·47, 0·93 for Q4v.Q1) and possibly AML (OR 0·42; 95 % CI 0·15, 1·15 for Q4v.Q1). No single index component appeared to account for the association. The association of maternal diet quality with risk of ALL was stronger in children diagnosed under the age of 5 years and in children of women who did not report using vitamin supplements before pregnancy. These findings suggest that the joint effects of many dietary components may be important in influencing childhood leukaemia risk.

Age-dependent biliary excretion of glutathione-related thiols in rats: role of gamma-glutamyltransferase

1987 ◽  
Vol 253 (1) ◽  
pp. G86-G92 ◽  
Author(s):  
Z. Gregus ◽  
A. F. Stein ◽  
C. D. Klaassen
Keyword(s):  
Postnatal Development ◽  
Biliary Excretion ◽  
Excretion Rate ◽  
Dependent Manner ◽  
Gamma Glutamyltransferase ◽  
Hydrolysis Products ◽  
Age Dependent ◽  
Old Rats ◽  
Hydrolysis Of

The role of gamma-glutamyltransferase (GGT) in the biliary excretion of glutathione (GS) was studied in rats during postnatal development. Between 2 and 10 wk of age the biliary excretion of GS-related sulfur increased ninefold. During this period, alterations were observed in both hepatic GGT and the composition of GS-related thiols and disulfides in bile. For instance, between 3 and 4 wk of age, GGT activity and the biliary excretion of GS hydrolysis products (Cys-Gly and Cys) increased markedly, and the latter became the predominant sulfhydryls in bile. However, by 10 wk of age, the excretion rate of GS increased and exceeded the rate of excretion of Cys-Gly and Cys. The parallelism between hepatic GGT activity and the biliary excretion of GS-hydrolysis products during development suggests a role for GGT in the formation of biliary Cys-Gly and Cys. Furthermore, in 4-wk-old rats, inhibition of hepatic GGT by acivicin markedly decreased the biliary excretion of Cys-Gly and Cys and increased that of GS without influencing the excretion of total GS-related sulfur in bile. The biliary excretion of GS-related thiols was less responsive to acivicin in 2- and 7- to 10-wk-old rats, suggesting that GGT plays a smaller role in influencing biliary thiol composition at those ages. In summary, GS transported into bile is hydrolyzed in an age-dependent manner, however, the GGT-initiated hydrolysis of GS does not affect the biliary excretion of total thiols in rats.

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