scholarly journals Effects of long-term blockade of angiotensin converting enzyme with captopril (SQ14,225) on hemodynamics and circulating blood volume in SHR.

Hypertension ◽  
1980 ◽  
Vol 2 (3) ◽  
pp. 299-303 ◽  
Author(s):  
H Koike ◽  
K Ito ◽  
M Miyamoto ◽  
H Nishino
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Blood Volume ◽  
Converting Enzyme ◽  
Circulating Blood Volume

scholarly journals Local Angiotensin-Converting Enzyme 2 Gene Expression in Kidney Allografts Is Not Affected by Renin-Angiotensin-Aldosterone Inhibitors

2021 ◽  
Vol 46 (2) ◽  
pp. 245-249
Author(s):  
Monika Cahova ◽  
Martin Kveton ◽  
Vojtech Petr ◽  
David Funda ◽  
Helena Dankova ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Kidney Transplant ◽  
Converting Enzyme ◽  
Transplant Recipients ◽  
Angiotensin Ii Receptor ◽  
Kidney Transplant Recipients ◽  
Angiotensin Converting Enzyme 2 ◽  
Renin Angiotensin ◽  
Receptor Blockers

<b><i>Background:</i></b> Preclinical studies suggested that pharmacological inhibition of the renin-angiotensin-aldosterone system (RAAS) by ACE inhibitors (ACEis) or angiotensin II receptor blockers (ARBs) may increase local angiotensin-converting enzyme 2 (<i>ACE2</i>) expression. <b><i>Methods:</i></b> In this study, we evaluated the effect of ACEi or ARB treatment on expression of <i>ACE2</i>, <i>ACE</i>, and <i>AGTR1</i> in 3-month protocol kidney allograft biopsies of stable patients using RT-qPCR (<i>n</i> = 48). Protein ACE2 expression was assessed using immunohistochemistry from paraffin sections. <b><i>Results:</i></b> The therapy with RAAS blockers was not associated with increased <i>ACE2, ACE</i>, or <i>ATGR1</i> expression in kidney allografts and also ACE2 protein immunohistochemistry did not reveal differences among groups. <b><i>Conclusions:</i></b> ACEis or ARBs in kidney transplant recipients do not affect local ACE2 expression. This observation supports long-term RAAS treatment in kidney transplant recipients, despite acute complications such as COVID-19 where ACE2 serves as the entry protein for infection.

scholarly journals Evaluation of circulating blood volume and vascular permeability in long-term hemodialysis patients

2011 ◽  
Vol 44 (5) ◽  
pp. 435-440 ◽  
Author(s):  
Susumu Ookawara ◽  
Masayuki Suzuki ◽  
Sachiko Fukase ◽  
Kaoru Tabei
Keyword(s):  
Vascular Permeability ◽  
Blood Volume ◽  
Hemodialysis Patients ◽  
Circulating Blood Volume

Pulmonary angiotensin-converting enzyme substrate hydrolysis during exercise

1992 ◽  
Vol 72 (5) ◽  
pp. 1868-1886 ◽  
Author(s):  
J. Dupuis ◽  
C. A. Goresky ◽  
J. W. Ryan ◽  
J. L. Rouleau ◽  
G. G. Bach
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Surface Area ◽  
Blood Volume ◽  
Extravascular Lung Water ◽  
Central Blood Volume ◽  
Converting Enzyme ◽  
Lung Water ◽  
Vascular Surface ◽  
Enzyme Substrate ◽  
Exercise Induced

We examined exercise-induced changes in indicator-dilution estimates of the angiotensin-converting enzyme first-order kinetic parameter, the ratio of a normalized maximal enzymatic conversion rate to the Michaelis constant (Amax/Km), which, under stable enzymatic conditions, will vary with the pulmonary vascular surface area accessible to vascular substrate, the extravascular lung water (an index of the proportion of lung tissue perfused), and the central blood volume (from pulmonary trunk to aorta). Experiments were performed in 10 mongrel dogs at rest and through two increasing levels of treadmill exercise, with the use of two vascular space tracers (labeled erythrocytes and albumin), a water space tracer ([1,8–14C]-octanediol), and a vascular endothelium surface area marker, benzoyl-Phe-Gly-Pro ([3H]BPGP), which is a pharmacologically inactive angiotensin-converting enzyme substrate. The exercise-induced increase in cardiac output was accompanied by a linear increase in central blood volume, and dilutional extravascular lung water rapidly increased to an asymptotic proportion close to 100% of postmortem vascular lung water. There was an average 55% [3H]BPGP hydrolysis, which did not vary with flow, and the computed Amax/Km increased linearly with exercise. We conclude that exercise results in complete lung tissue recruitment and increases the pulmonary vascular surface area available for BPGP hydrolysis linearly with flow, so that pulmonary vascular recruitment continues after full tissue recruitment.

SIADH: A Case Review

2001 ◽  
Vol 20 (1) ◽  
pp. 29-33 ◽  
Author(s):  
Lee Shirland
Keyword(s):  
Antidiuretic Hormone ◽  
Blood Volume ◽  
Clinical Course ◽  
Case Review ◽  
Long Term Outcomes ◽  
Circulating Blood Volume ◽  
Neurologic Sequelae ◽  
Effective Circulating Blood Volume

Because the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) can cause neurologic sequelae with the potential to affect long-term outcomes, its prompt recognition and treatment are essential. Normally, antidiuretic hormone (ADH) is secreted when effective circulating blood volume is decreased. SIADH is marked by secretion of ADH in the presence of effective or normal circulating blood volume. This causes plasma hyponatremia simultaneously with plasma hypo-osmolality and inappropriate hyperosmolality of the urine. This article explains the pathophysiology of the syndrome; describes its diagnosis, clinical course, and treatment; and exemplifies the syndrome with a case study.

scholarly journals Long-Term Antihypertensive Effect of Angiotensin-Converting Enzyme Inhibitory Peptide LAP

2011 ◽  
Vol 34 (5) ◽  
pp. 358-364 ◽  
Author(s):  
Luo Ming ◽  
Shen Yi ◽  
Liu Chi ◽  
Huan Zheng ◽  
Zhanxia Li ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Antihypertensive Effect ◽  
Converting Enzyme ◽  
Inhibitory Peptide
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