Effects of Selective Dropout on Infant Growth Standards

Author(s):  
Stef van Buuren
Nutrients ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1654
Author(s):  
Jacques Rigo ◽  
Stefanie Schoen ◽  
Marc Verghote ◽  
Bart van Overmeire ◽  
Wivinne Marion ◽  
...  

The current study aimed to investigate growth, safety and tolerance of partially hydrolysed infant formulae in healthy full-term infants. Fully formula-fed infants were randomised ≤14 days of age to receive a partially hydrolysed whey formula with 2.27 g protein/100 kcal (pHF2.27) or the same formula with 1.8 g or 2.0 g protein/100 kcal (pHF1.8 and pHF2.0) until 4 months of age. The primary outcome was equivalence in daily weight gain within margins of ± 3 g/day; comparison with WHO Child Growth Standards; gastrointestinal tolerance parameters and number of (serious) adverse events were secondary outcomes. A total of 207 infants were randomised, and 61 (pHF1.8), 46 (pHF2.0) and 48 (pHF2.27) infants completed the study per protocol. Equivalence in daily weight gain was demonstrated for the comparison of pHF1.8 and pHF2.27, i.e., the estimated difference was −1.12 g/day (90% CI: [−2.72; 0.47]) but was inconclusive for the comparisons of pHF2.0 and pHF2.27 with a difference of −2.52 g/day (90% CI: [−4.23; −0.81]). All groups showed adequate infant growth in comparison with the World Health Organization (WHO) Child Growth Standards. To conclude, the evaluated partially hydrolysed formulae varying in protein content support adequate growth and are safe and well tolerated in healthy infants.


Author(s):  
Marisol Garzón ◽  
Ana Luísa Papoila ◽  
Marta Alves ◽  
Luís Pereira-da-Silva

This birth cohort study compared the infant growth curve estimates in São Tomé Island to the WHO growth standards. Despite this island belonging to a lower-middle-income country, there were several factors favorable for growth that were present. Four-hundred and seventy-five full-term singleton appropriate for-gestational-age infants were enrolled and followed-up to 24 months of age. Weight-for-age, length-for-age, weight-for-length, body mass index-for-age, head circumference-for-age, weight velocity, and length velocity curves were estimated and compared to the WHO standards. In the first 6 months of age, the weight gain was adequate in the presence of a high prevalence of exclusive breastfeeding. Thereafter, weight trajectories tracked close to the WHO standards, except for a progressive decline in the infants growing in higher percentiles, especially in girls. Median length at birth was below the median WHO standards, followed by an early postnatal velocity spurt, which probably reflected the transition from an unfavorable to a more favorable postnatal environment. Thereafter, linear growth faltering was observed without relevant deterioration up to 24 months of age, which was probably due to the presence of protective factors. These results may be useful to implement strategies to further approximate infant growth in São Tomé Island to the WHO standards.


2015 ◽  
Vol 67 (1) ◽  
pp. 49-57 ◽  
Author(s):  
Jill C. Diesel ◽  
Cara L. Eckhardt ◽  
Nancy L. Day ◽  
Maria M. Brooks ◽  
Silva A. Arslanian ◽  
...  

Background: Excessive gestational weight gain (GWG) increases the risk of childhood obesity, but little is known about its association with infant growth patterns. Aim: The aim of this study was to examine the association between GWG and infant growth patterns. Methods: Pregnant women (n = 743) self-reported GWG at delivery, which we classified as inadequate, adequate or excessive based on the current guidelines. Offspring weight-for-age z-score (WAZ), length-for-age z-score (LAZ (with height-for-age (HAZ) in place of length at 36 months)) and body mass index z-score (BMIZ) were calculated at birth, 8, 18 and 36 months using the 2006 World Health Organization growth standards. Linear mixed models estimated the change in z-score from birth to 36 months by GWG. Results: The mean (SD) WAZ was -0.22 (1.20) at birth. Overall, WAZ and BMIZ increased from birth to, approximately, 24 months and decreased from 24 to 36 months, while LAZ/HAZ decreased from birth through 36 months. Excessive GWG was associated with higher offspring WAZ and BMIZ at birth, 8 and 36 months, and higher HAZ at 36 months, compared with adequate GWG. Compared with the same referent, inadequate GWG was associated with smaller WAZ and BMIZ at birth and 8 months. Conclusion: Excessive GWG may predispose infants to obesogenic growth patterns, while inadequate GWG may not have a lasting impact on infant growth.


1979 ◽  
Vol 18 (10) ◽  
pp. 602-603 ◽  
Author(s):  
Mary Ann Sedgwick Harvey ◽  
David W. Smith ◽  
Alfred L. Skinner

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 342-OR
Author(s):  
SARAH J. BORENGASSER ◽  
ANNE P. STARLING ◽  
WEIMING ZHANG ◽  
JACOB FRIEDMAN ◽  
RICHARD F. HAMMAN ◽  
...  

2020 ◽  
Vol 59 (3) ◽  
pp. 468
Author(s):  
Ksenia Olisova ◽  
Chan-Yu Sung ◽  
Yi-Ying Li ◽  
Ching-Chi Hsia ◽  
Tung-Yao Chang

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