scholarly journals Partially Hydrolysed Whey-Based Formulae with Reduced Protein Content Support Adequate Infant Growth and Are Well Tolerated: Results of a Randomised Controlled Trial in Healthy Term Infants

Nutrients ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1654
Author(s):  
Jacques Rigo ◽  
Stefanie Schoen ◽  
Marc Verghote ◽  
Bart van Overmeire ◽  
Wivinne Marion ◽  
...  

The current study aimed to investigate growth, safety and tolerance of partially hydrolysed infant formulae in healthy full-term infants. Fully formula-fed infants were randomised ≤14 days of age to receive a partially hydrolysed whey formula with 2.27 g protein/100 kcal (pHF2.27) or the same formula with 1.8 g or 2.0 g protein/100 kcal (pHF1.8 and pHF2.0) until 4 months of age. The primary outcome was equivalence in daily weight gain within margins of ± 3 g/day; comparison with WHO Child Growth Standards; gastrointestinal tolerance parameters and number of (serious) adverse events were secondary outcomes. A total of 207 infants were randomised, and 61 (pHF1.8), 46 (pHF2.0) and 48 (pHF2.27) infants completed the study per protocol. Equivalence in daily weight gain was demonstrated for the comparison of pHF1.8 and pHF2.27, i.e., the estimated difference was −1.12 g/day (90% CI: [−2.72; 0.47]) but was inconclusive for the comparisons of pHF2.0 and pHF2.27 with a difference of −2.52 g/day (90% CI: [−4.23; −0.81]). All groups showed adequate infant growth in comparison with the World Health Organization (WHO) Child Growth Standards. To conclude, the evaluated partially hydrolysed formulae varying in protein content support adequate growth and are safe and well tolerated in healthy infants.

2015 ◽  
Vol 67 (1) ◽  
pp. 49-57 ◽  
Author(s):  
Jill C. Diesel ◽  
Cara L. Eckhardt ◽  
Nancy L. Day ◽  
Maria M. Brooks ◽  
Silva A. Arslanian ◽  
...  

Background: Excessive gestational weight gain (GWG) increases the risk of childhood obesity, but little is known about its association with infant growth patterns. Aim: The aim of this study was to examine the association between GWG and infant growth patterns. Methods: Pregnant women (n = 743) self-reported GWG at delivery, which we classified as inadequate, adequate or excessive based on the current guidelines. Offspring weight-for-age z-score (WAZ), length-for-age z-score (LAZ (with height-for-age (HAZ) in place of length at 36 months)) and body mass index z-score (BMIZ) were calculated at birth, 8, 18 and 36 months using the 2006 World Health Organization growth standards. Linear mixed models estimated the change in z-score from birth to 36 months by GWG. Results: The mean (SD) WAZ was -0.22 (1.20) at birth. Overall, WAZ and BMIZ increased from birth to, approximately, 24 months and decreased from 24 to 36 months, while LAZ/HAZ decreased from birth through 36 months. Excessive GWG was associated with higher offspring WAZ and BMIZ at birth, 8 and 36 months, and higher HAZ at 36 months, compared with adequate GWG. Compared with the same referent, inadequate GWG was associated with smaller WAZ and BMIZ at birth and 8 months. Conclusion: Excessive GWG may predispose infants to obesogenic growth patterns, while inadequate GWG may not have a lasting impact on infant growth.


2011 ◽  
Vol 36 (4) ◽  
pp. 562-569 ◽  
Author(s):  
Andrea Nash ◽  
Michael Dunn ◽  
Elizabeth Asztalos ◽  
Mary Corey ◽  
Bridget Mulvihill-Jory ◽  
...  

Several Canadian professional organizations recently recommended that the growth of preterm infants be monitored using the World Health Organization Growth Standards (WHO-GS) after hospital discharge. The WHO-GS are a prescriptive set of growth charts that describe how term infants should grow under ideal environmental conditions. Whether preterm infants following this pattern of growth have better outcomes than infants that do not has yet to be evaluated. Our aim was to determine whether the pattern of growth of very low birth weight (VLBW) infants during the first 2 years, assessed using the WHO-GS or the traditional Centers for Disease Control and Prevention reference growth charts (CDC-RGC), is associated with neurodevelopment. Pattern of weight, length, and head circumference gain of appropriate-for-gestation VLBW preterm infants (n = 289) from birth to 18–24 months corrected age was classified, using the WHO-GS and CDC-RGC, as sustained (change in Z-score ≤1 SD), decelerated (decline >1 SD), or accelerated (incline >1 SD). Development was assessed using the Bayley Scales of Infant and Toddler Development (BSID)-III at 18–24 months corrected age. Using the WHO-GS, children with a decelerated pattern of weight gain had lower cognitive (10 points), language (6 points), and motor (4 points) scores than infants with sustained weight gain (p < 0.05), even after adjustment for morbidities. No association was found using the CDC-RGC. In conclusion, a decelerated pattern of weight gain, determined with the WHO-GS, but not the CDC-GRC, is associated with poorer neurodevelopment scores on the BSID-III than a pattern of sustained growth.


Children ◽  
2021 ◽  
Vol 8 (2) ◽  
pp. 133
Author(s):  
Perpetua Modjadji ◽  
Mpinane Pitso

Tobacco and alcohol use among mothers is associated with numerous adverse consequences for affected offspring, including poor growth and development. This study determined the association between maternal tobacco and alcohol use, and malnutrition, among infants aged ≤ 12 months (n = 300), in selected health facilities situated in Gauteng, South Africa. Data on alcohol and tobacco use were collected using a validated questionnaire, in addition to mothers’ socio-demographic characteristics and obstetric history. Stunting (low height/length-for-age), underweight (low weight-for-age) and thinness (low body mass index-for-age) were calculated using z-scores based on the World Health Organization child growth standards. The association of tobacco and alcohol use with stunting, underweight and thinness was analysed using logistic regression analysis. The results showed a mean age of 29 years (24.0; 35.0) for mothers and 7.6 ± 3 months for infants, and over half of the mothers were unemployed (63%). Approximately 18.7% of mothers had used tobacco and 3% had used alcohol during pregnancy. The prevalence of current tobacco and alcohol use among mothers were estimated at 14.3% and 49.7%, respectively, and almost three-quarters (67.3%) of them were still breastfeeding during the study period. Stunting (55%) was the most prevalent malnutrition indicator among infants, while underweight was 41.7%, and thinness was 22%. Current tobacco use was associated with increased odds of being thin [OR = 2.40, 95% CI: 1.09–5.45), and after adjusting for confounders, current alcohol use was associated with the likelihood of being underweight [AOR = 1.96, 95% CI: 1.06–3.63] among infants. Future prospective cohort studies that examine growth patterns among infants who are exposed to maternal tobacco and alcohol use from the intrauterine life to infancy are necessary to inform, partly, the public health programmes, to reduce malnutrition among children.


2005 ◽  
Vol 25 (2) ◽  
pp. 247-265 ◽  
Author(s):  
E. Borghi ◽  
M. de Onis ◽  
C. Garza ◽  
J. Van den Broeck ◽  
E. A. Frongillo ◽  
...  

2013 ◽  
Vol 57 (2) ◽  
pp. 258-264 ◽  
Author(s):  
Dominique Turck ◽  
Kim F. Michaelsen ◽  
Raanan Shamir ◽  
Christian Braegger ◽  
Cristina Campoy ◽  
...  

2019 ◽  
Vol 2 (1) ◽  
pp. 8
Author(s):  
Jean Fanny Junita Timban ◽  
Ellen Grace Tangkere ◽  
Jelly Ribka Danaly Lumingkewas

Stunting in under-five children is a reduced growth rate primarily caused by chronic undernutrition that leads to a child having height much less than is normal for age. This condition manifests mostly after two years old. The definition of stunting according to the World Health Organization (WHO) is for the "height for age" value to be less than two standard deviations of the WHO Child Growth Standards median. Indonesia has been plagued recently with stunting. In 2015, the World Bank indicates that stunting has cost 3 to 11 percent of the gross domestic product. Previous research works have documented that mothers play an important role in preventing stunting through antenatal care and child nursing. The objective of this study is to explore the role played by the mothers in Bunaken, Manado, in antenatal care and child nursing that prevent stunting. Samples are drawn using purposive sampling and data are analysis descriptively. The results show that the mothers’ roles include taking antenatal check up to four times during pregnancy, daily use of FE 90 pill, participating in pregnancy counseling and care, delivery by health professionals, attending integrated service post (posyandu), visiting health professionals for postnatal care, completing universal immunization on child over 12 months old, and participating in educational activities for under-five nursing and nutritional fulfillment at least once a month. Of these eight recorded roles, however, there are merely 20% mothers indicate they regularly taking part in pregnancy counseling and care. Furthermore, only one percent (n = 3) respondents that report they attending educational activities for under-five nursing and nutritional fulfillment.


2021 ◽  
Vol 37 (1) ◽  
pp. 50-60
Author(s):  
G. O. Achadu ◽  
F. O. I. Anugwu ◽  
F. G. Kaankuka

Sixteen crossbred pigs (Large Whie x Landrace x Hamoshire) were used in two feeding trials to evaluate the replacement value of brewers yeast slurry-maize offal mixture (BYS-MO) for full fat soybean (FFSB) and maize in the diets of pigs, and in addition to determine carcass characteristics in experiment 2. In experiment 1 four isocaloric (3250 Kcal/kg) and isonitrogenous (18% crude protein maize - full - fat soybean based diets containing 0, 22.75, 40 and 59.15% of a 1.5: 1 (weight/weight) mixture of BYS_MO were fed ad libitum for 30 days. Parameters concluded included daily feed intake, daily weight gain, feed to gain ratio, protein efficiency ratio, cost per kg weight gain, linear and jointed carcass parameters and weights of internal organs. Due to the high protein content (44.3% of CP) of BYS, the BYS_MO mixture gave a product whose protein content of 34.3% was close to that of FFSB (36.4% CP). There were no significant differences (P>0.05) among treatments in all the parameters measured. However, the cost of feed was lower for the diets containing BYS-MO than the control diets in both experiments, thereby reducing the cost per kg weight gain from #129.20 to #96.20, #84.00 and #43.50 respectively for diets i, ii, iii and iv in experiment 1 and from #133.37 to #116.38, #109.77 and #108.06 respectively for diets i, ii, iii and iv in experiment 2. The 1.5:1 (weight/weight) brewers yeast slurry-maize offal mixtutre can replace up to 40 to 59% of maize and full fat soybeans in diets for weaner-grower pigs and finishing pigs withoutv any adverse effects on performance and carcass quality.


Author(s):  
Wen-Chien Yang ◽  
Chun-Min Fu ◽  
Bo-Wei Su ◽  
Chung-Mei Ouyang ◽  
Kuen-Cheh Yang

High prevalence of child underweight and stunting in high-altitude areas has often been reported. However, most previous studies on this topic were cross-sectional. Another critical concern is that using the World Health Organization (WHO) Child Growth Standards to evaluate child growth in high-altitude areas may lead to overestimations of underweight and stunting. Our study aimed to evaluate the long-term growth pattern of children (3 to 18 years) above the altitude of 3500 m in Ladakh, India. The participants’ body weight (BW), body height (BH), and body mass index (BMI) were measured annually according to the WHO Child Growth Standards for children under 5 years old and the WHO reference data for children aged 5 to 19 years. The generalized estimating equation (GEE) was used to estimate the means and z-scores of BW, BH, and BMI at different ages. A total of 401 children were enrolled from 2012 to 2018. Their mean z-scores of BW, BH, and BMI were −1.47, −1.44, and −0.85 in 2012 and increased to −0.74, −0.92, and −0.63 in 2018. This population’s specific growth curve was also depicted, which generally fell below the 85th percentile of the WHO standards. This is the first cohort study about long-term child growth patterns in a high-altitude area. The detailed underlying mechanisms of our findings need future research on more representative data of high-altitude populations.


2021 ◽  
Vol 7 (2) ◽  
pp. 98
Author(s):  
Nafiys Hilmy ◽  
Maitsa' Fatharani

Stunting is one of the remaining health issues in Indonesia and its prevalence was still high in the last decades. There are two types of growth charts that can be used in recording the child's growth: growth standards and growth references. In recent times, the selection of the suitable growth charts has become a subject of discussion in many countries. The objective of this study is to describe the prevalence of stunting according to World Health Organization Child Growth Standards (WHOCGS) and Indonesian National Growth Reference Charts (INGRC) of children under five from the Blega sub-district. The secondary data from 2884 children were collected recapitulation of the 'Bulan Timbang' program in February 2020. Z-score of length/height-for-age was plotted according to WHOCGS and INGRC. The result showed that the prevalence of stunting were lower for the INGRC than WHOCGS (5.83% and 11.17%, with p-value <0.001). There was an advantage and disadvantage when using both two growth charts. Further research is still needed to support the result of this study. Keywords:  Stunting, World Health Organization Child Growth Standards, Indonesian National Growth Reference Charts


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