DNA Methylation at Birth Is Associated with Adiposity and Infant Growth during the First Six Months of Life in the Healthy Start Study

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 342-OR
Author(s):  
SARAH J. BORENGASSER ◽  
ANNE P. STARLING ◽  
WEIMING ZHANG ◽  
JACOB FRIEDMAN ◽  
RICHARD F. HAMMAN ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Infant Growth ◽  
Healthy Start

scholarly journals In Utero Exposures, Infant Growth, and DNA Methylation of Repetitive Elements and Developmentally Related Genes in Human Placenta

2012 ◽  
Vol 120 (2) ◽  
pp. 296-302 ◽  
Author(s):  
Charlotte S. Wilhelm-Benartzi ◽  
E. Andres Houseman ◽  
Matthew A. Maccani ◽  
Graham M. Poage ◽  
Devin C. Koestler ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Human Placenta ◽  
In Utero ◽  
Infant Growth ◽  
Repetitive Elements ◽  
In Utero Exposures

scholarly journals Exploring the association between maternal prenatal multivitamin use and early infant growth: The Healthy Start Study

2015 ◽  
Vol 11 (5) ◽  
pp. 434-441 ◽  
Author(s):  
K. A. Sauder ◽  
A. P. Starling ◽  
A. L. Shapiro ◽  
J. L. Kaar ◽  
B. M. Ringham ◽  
...  
Keyword(s):  
Infant Growth ◽  
Healthy Start ◽  
Early Infant ◽  
Multivitamin Use

scholarly journals The Influence of the Duration of Breastfeeding on the Infant’s Metabolic Epigenome

Nutrients ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1408 ◽  
Author(s):  
Sara Pauwels ◽  
Lin Symons ◽  
Eva-Lynn Vanautgaerden ◽  
Manosij Ghosh ◽  
Radu Corneliu Duca ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Maternal Nutrition ◽  
Positive Association ◽  
Postnatal Period ◽  
Infant Growth ◽  
Breastfeeding Duration ◽  
Epigenetic Changes ◽  
Significant Difference ◽  
Underlying Mechanisms ◽  
Duration Of Breastfeeding

Nutrition in the postnatal period is associated with metabolic programming. One of the presumed underlying mechanisms involves epigenetic modifications (e.g., DNA methylation). Breastfeeding has an unknown impact on DNA methylation at a young age. Within the Maternal Nutrition and Offspring’s Epigenome (MANOE) study, we assessed the effect of breastfeeding duration on infant growth and buccal methylation in obesity-related genes (n = 101). A significant difference was found between infant growth and buccal RXRA and LEP methylation at 12 months of breastfeeding. For RXRA CpG2 methylation, a positive association was found with duration of breastfeeding (slope = 0.217; 95% confidence interval (CI) 1.03, 0.330; p < 0.001). For RXRA CpG3 and CpG, mean methylation levels were significantly lower when children were breastfed for 4–6 months compared to non-breastfed children (only CpG3), and those breastfed for 7–9 months, 10–12 months, or 1–3 months. On the other hand, higher LEP CpG3 methylation was observed when mothers breastfed 7–9 months (6.1%) as compared to breastfeeding for 1–3 months (4.3%; p = 0.007) and 10–12 months (4.6%; p = 0.04). In addition, we observed that infant weight was significantly lower when children were breastfed for 10–12 months. Breastfeeding duration was associated with epigenetic variations in RXRA and LEP at 12 months and with infant biometry/growth. Our results support the hypothesis that breastfeeding could induce epigenetic changes in infants.

scholarly journals Prenatal exposure to per- and polyfluoroalkyl substances and infant growth and adiposity: the Healthy Start Study

2019 ◽  
Vol 131 ◽  
pp. 104983 ◽  
Author(s):  
Anne P. Starling ◽  
John L. Adgate ◽  
Richard F. Hamman ◽  
Katerina Kechris ◽  
Antonia M. Calafat ◽  
...  
Keyword(s):  
Prenatal Exposure ◽  
Infant Growth ◽  
Healthy Start ◽  
Polyfluoroalkyl Substances

Prenatal phthalate exposure, infant growth, and global DNA methylation of human placenta

2014 ◽  
Vol 56 (3) ◽  
pp. 286-292 ◽  
Author(s):  
Yan Zhao ◽  
Hui-jing Shi ◽  
Chang-ming Xie ◽  
Jiao Chen ◽  
Hannah Laue ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Human Placenta ◽  
Infant Growth ◽  
Global Dna Methylation ◽  
Phthalate Exposure

scholarly journals Infant growth restriction is associated with distinct patterns of DNA methylation in human placentas

Epigenetics ◽  
2011 ◽  
Vol 6 (7) ◽  
pp. 920-927 ◽  
Author(s):  
Carolyn E. Banister ◽  
Devin C. Koestler ◽  
Matthew A. Maccani ◽  
James F. Padbury ◽  
E. Andres Houseman ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Infant Growth ◽  
Growth Restriction

scholarly journals DNA Methylation of IGF2DMR and H19 Is Associated with Fetal and Infant Growth: The Generation R Study

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e81731 ◽  
Author(s):  
Marieke I. Bouwland-Both ◽  
Nina H. van Mil ◽  
Lisette Stolk ◽  
Paul H. C. Eilers ◽  
Michael M. P. J. Verbiest ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Infant Growth

DNA methylation in satellite repeats disorders

2019 ◽  
Vol 63 (6) ◽  
pp. 757-771 ◽  
Author(s):  
Claire Francastel ◽  
Frédérique Magdinier
Keyword(s):  
Dna Methylation ◽  
Human Genome ◽  
Repetitive Dna ◽  
Dna Sequences ◽  
Satellite Repeats ◽  
Tremendous Progress ◽  
Genes Encoding ◽  
Dna Elements ◽  
Near Future

Abstract Despite the tremendous progress made in recent years in assembling the human genome, tandemly repeated DNA elements remain poorly characterized. These sequences account for the vast majority of methylated sites in the human genome and their methylated state is necessary for this repetitive DNA to function properly and to maintain genome integrity. Furthermore, recent advances highlight the emerging role of these sequences in regulating the functions of the human genome and its variability during evolution, among individuals, or in disease susceptibility. In addition, a number of inherited rare diseases are directly linked to the alteration of some of these repetitive DNA sequences, either through changes in the organization or size of the tandem repeat arrays or through mutations in genes encoding chromatin modifiers involved in the epigenetic regulation of these elements. Although largely overlooked so far in the functional annotation of the human genome, satellite elements play key roles in its architectural and topological organization. This includes functions as boundary elements delimitating functional domains or assembly of repressive nuclear compartments, with local or distal impact on gene expression. Thus, the consideration of satellite repeats organization and their associated epigenetic landmarks, including DNA methylation (DNAme), will become unavoidable in the near future to fully decipher human phenotypes and associated diseases.

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