Reduced Adjuvant Activity of Bordetella pertussis Vaccine in Mice after Priming with an Immunogenic Threshold Dose

1970 ◽  
Vol 39 (1) ◽  
pp. 45-55 ◽  
Author(s):  
H. Finger ◽  
P. Emmerling ◽  
A. Offenhammer
Keyword(s):  
Bordetella Pertussis ◽  
Threshold Dose ◽  
Adjuvant Activity

Variable Adjuvant Activity of Bordetella pertussis with Respect to the Primary and Secondary Immunization of Mice

1970 ◽  
Vol 1 (3) ◽  
pp. 251-258
Author(s):  
H. Finger ◽  
P. Emmerling ◽  
E. Brüss
Keyword(s):  
Immune Responses ◽  
Bordetella Pertussis ◽  
Serum Antibody ◽  
Secondary Response ◽  
Primary Immunization ◽  
Spleen Cells ◽  
Adjuvant Effect ◽  
Adjuvant Activity ◽  
Sheep Erythrocytes ◽  
X Cells

We carried out a study on the adjuvant effect of Bordetella pertussis vaccine on the primary and secondary immune responses of the mouse to sheep erythrocytes, quantitating antibody-producing spleen cells and serum antibody. The simultaneous injection of sheep erythrocytes and B. pertussis , when compared to immunization with sheep red blood cells alone, resulted in an increased and prolonged multiplication of antibody-forming spleen cells. The adjuvant effect was also documented by increased production of serum hemolysins and agglutinins. Further, B. pertussis enhanced the priming effect of the antigen for the secondary response. However, when the bacterial adjuvant was given together with a second antigenic stimulus 41 days after the primary immunization, the peak values of direct and indirect plaque-forming spleen cells did not differ from the corresponding control animals further inoculated with sheep erythrocytes alone. Nonetheless, the influence of the bacterial adjuvant was still expressed by the delayed decrease of the numbers of plaque-forming spleen cells. On the basis of the X-Y-Z scheme it is suggested that B. pertussis cells as adjuvant enhance the multiplication of antigen-sensitive X cells or affect the initial stages of differentiation of these cells. This effect of the pertussis vaccine can be distinguished from a general proliferative action on other cells.

scholarly journals Adjuvant Activity of Free Bordetella Pertussis Filamentous Haemagglutinin Delivered by Mucosal Routes

2003 ◽  
Vol 58 (5) ◽  
pp. 503-510 ◽  
Author(s):  
O. Poulain-Godefroy ◽  
F. D. Menozzi ◽  
S. Alonso ◽  
C. Vendeville ◽  
A. Capron ◽  
...  
Keyword(s):  
Bordetella Pertussis ◽  
Adjuvant Activity

Antigen-sensitive spleen cells and the adjuvant activity of Bordetella pertussis

1970 ◽  
Vol 16 (7) ◽  
pp. 623-627 ◽  
Author(s):  
H. Finger ◽  
P. Emmerling ◽  
M. Büsse
Keyword(s):  
Immune Response ◽  
Bordetella Pertussis ◽  
Primary Immune Response ◽  
Target Cells ◽  
Primary Immunization ◽  
Spleen Cells ◽  
Adjuvant Effect ◽  
Adjuvant Activity ◽  
Simultaneous Injection ◽  
Sheep Erythrocytes

In this study we determined at both the cellular and humoral level whether or not the primary immune response of mice can be significantly enhanced by administration of a bacterial adjuvant after the primary immunization with sheep erythrocytes. As compared to the immunization of mice with 8 × 106 sheep erythrocytes alone, the simultaneous injection of 3 × 109Bordetella pertussis cells and 8 × 106 sheep erythrocytes resulted in an accelerated and prolonged multiplication of hemolysin-forming spleen cells. The adjuvant effect was also documented by increased production of serum hemolysins. When the bacterial adjuvant was given 6, 12, or 24 h after the primary antigenic stimulus, however, neither increased plaque counts nor enhanced serum hemolysin titers were detectable. These findings agree with the concept that B. pertussis cells cause multiplication of antigen-sensitive target cells or affect the initial stages of differentiation of these cells.

Das klinische Bild der Pertussis bei Jugendlichen und Erwachsenen

2004 ◽  
Vol 4 (02) ◽  
pp. 55-60
Author(s):  
Johannes Liese
Keyword(s):  
Bordetella Pertussis

ZusammenfassungPertussis wird im Allgemeinen als typische Erkrankung des Kindesalters betrachtet. Jedoch finden sich immer wieder Beschreibungen über das Auftreten von Pertussis bei Jugendlichen und Erwachsenen. Nachdem die Durchimpfungsraten gegen Pertussis im Kindesalter seit Mitte der 90er-Jahre stark angestiegen sind, werden nun in Deutschland, wie in anderen Populationen mit einer hohen Durchimpfungsrate, zunehmend Pertussisinfektionen bei Jugendlichen und Erwachsenen diagnostiziert. Diese Infektionen zeigen ein weites Spektrum in der klinischen Manifestation, von in der Regel milden Hustenerkrankungen bis hin zu seltenen, aber teilweise schweren Komplikationen. Erwachsene sind insbesondere auch als Infektionsreservoir für die Weiterverbreitung von Bordetella pertussis auf nicht-immune Personen von Bedeutung. Der vorliegende Artikel fasst den derzeitigen Stand der Epidemiologie und Klinik der Pertussis bei Erwachsenen zusammen und diskutiert die derzeitigen und zukünftigen Möglichkeiten der Impfprävention.

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