The Effect of Tetanus Toxin on Neuromuscular Transmission

H.E. Kaeser; A. Saner

doi:10.1159/000113971

The Effect of Tetanus Toxin on Neuromuscular Transmission

European Neurology ◽

10.1159/000113971 ◽

1970 ◽

Vol 3 (4) ◽

pp. 193-205 ◽

Cited By ~ 28

Author(s):

H.E. Kaeser ◽

A. Saner

Keyword(s):

Tetanus Toxin ◽

Neuromuscular Transmission

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Action of tetanus toxin on neuromuscular transmission

Bulletin of Experimental Biology and Medicine ◽

10.1007/bf00785008 ◽

1964 ◽

Vol 58 (4) ◽

pp. 1199-1203

Author(s):

G. N. Kryzhanovskii ◽

A. Kh. Kasymov

Keyword(s):

Tetanus Toxin ◽

Neuromuscular Transmission

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Tetanus toxin blocks the neuromuscular transmission in vitro like botulinum a toxin

Naunyn-Schmiedeberg s Archives of Pharmacology ◽

10.1007/bf00500299 ◽

1980 ◽

Vol 311 (1) ◽

pp. 33-40 ◽

Cited By ~ 114

Author(s):

E. Habermann ◽

F. Dreyer ◽

H. Bigalke

Keyword(s):

Tetanus Toxin ◽

Neuromuscular Transmission ◽

Botulinum A Toxin

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Relations between the effect of tetanus toxin on the neuromuscular transmission and histological functional properties of various muscles of the rat

Experimental Brain Research ◽

10.1007/bf00236739 ◽

1980 ◽

Vol 38 (2) ◽

Cited By ~ 11

Author(s):

H. Kretzschmar ◽

F. Kirchner ◽

K. Takano

Keyword(s):

Functional Properties ◽

Tetanus Toxin ◽

Neuromuscular Transmission

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At least three sequential steps are involved in the tetanus toxin-induced block of neuromuscular transmission

Naunyn-Schmiedeberg s Archives of Pharmacology ◽

10.1007/bf00501314 ◽

1981 ◽

Vol 317 (4) ◽

pp. 326-330 ◽

Cited By ~ 68

Author(s):

A. Schmitt ◽

F. Dreyer ◽

Christine John

Keyword(s):

Tetanus Toxin ◽

Neuromuscular Transmission

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The effects of tetanus toxin on neuromuscular transmission and on the morphology of motor end-plates in slow and fast skeletal muscle of the mouse

The Journal of Physiology ◽

10.1113/jphysiol.1973.sp010078 ◽

1973 ◽

Vol 228 (1) ◽

pp. 157-172 ◽

Cited By ~ 114

Author(s):

L. W. Duchen ◽

D. A. Tonge

Keyword(s):

Skeletal Muscle ◽

Tetanus Toxin ◽

Neuromuscular Transmission ◽

Fast Skeletal Muscle ◽

Motor End Plates

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Fragment A-B of tetanus toxin does not block neuromuscular transmission in the goldfish

Toxicon ◽

10.1016/0041-0101(90)90266-a ◽

1990 ◽

Vol 28 (6) ◽

pp. 737-741 ◽

Cited By ~ 1

Author(s):

J. Mellanby ◽

M. Matsuda ◽

N. Sugimoto ◽

D.-L. Lei ◽

B. Bizzini

Keyword(s):

Tetanus Toxin ◽

Neuromuscular Transmission

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Two-Dimensional Crystallization of Tetanus Toxin

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100119466 ◽

1985 ◽

Vol 43 ◽

pp. 528-529

Author(s):

Jeffry A. Reidler ◽

John P. Robinson

Keyword(s):

Electron Microscopy ◽

Tetanus Toxin ◽

Structural Information ◽

Three Dimensional ◽

Two Dimensional ◽

Membrane Interface ◽

3D Reconstructions ◽

Cellular Receptors ◽

Computer Reconstruction ◽

2D Crystals

We have prepared two-dimensional (2D) crystals of tetanus toxin using procedures developed by Uzgiris and Kornberg for the directed production of 2D crystals of monoclonal antibodies at an antigen-phospholipid monolayer interface. The tetanus toxin crystals were formed using a small mole fraction of the natural receptor, GT1, incorporated into phosphatidyl choline monolayers. The crystals formed at low concentration overnight. Two dimensional crystals of this type are particularly useful for structure determination using electron microscopy and computer image refinement. Three dimensional (3D) structural information can be derived from these crystals by computer reconstruction of photographs of toxin crystals taken at different tilt angles. Such 3D reconstructions may help elucidate the mechanism of entry of the enzymatic subunit of toxins into cells, particularly since these crystals form directly on a membrane interface at similar concentrations of ganglioside GT1 to the natural cellular receptors.

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