At least three sequential steps are involved in the tetanus toxin-induced block of neuromuscular transmission

1981 ◽  
Vol 317 (4) ◽  
pp. 326-330 ◽  
Author(s):  
A. Schmitt ◽  
F. Dreyer ◽  
Christine John
Keyword(s):  
Tetanus Toxin ◽  
Neuromuscular Transmission

Action of tetanus toxin on neuromuscular transmission

1964 ◽  
Vol 58 (4) ◽  
pp. 1199-1203
Author(s):  
G. N. Kryzhanovskii ◽  
A. Kh. Kasymov
Keyword(s):  
Tetanus Toxin ◽  
Neuromuscular Transmission

The Effect of Tetanus Toxin on Neuromuscular Transmission

1970 ◽  
Vol 3 (4) ◽  
pp. 193-205 ◽  
Author(s):  
H.E. Kaeser ◽  
A. Saner
Keyword(s):  
Tetanus Toxin ◽  
Neuromuscular Transmission

Fragment A-B of tetanus toxin does not block neuromuscular transmission in the goldfish

Toxicon ◽  
1990 ◽  
Vol 28 (6) ◽  
pp. 737-741 ◽  
Author(s):  
J. Mellanby ◽  
M. Matsuda ◽  
N. Sugimoto ◽  
D.-L. Lei ◽  
B. Bizzini
Keyword(s):  
Tetanus Toxin ◽  
Neuromuscular Transmission

Two-Dimensional Crystallization of Tetanus Toxin

1985 ◽  
Vol 43 ◽  
pp. 528-529
Author(s):  
Jeffry A. Reidler ◽  
John P. Robinson
Keyword(s):  
Electron Microscopy ◽  
Tetanus Toxin ◽  
Structural Information ◽  
Three Dimensional ◽  
Two Dimensional ◽  
Membrane Interface ◽  
3D Reconstructions ◽  
Cellular Receptors ◽  
Computer Reconstruction ◽  
2D Crystals

We have prepared two-dimensional (2D) crystals of tetanus toxin using procedures developed by Uzgiris and Kornberg for the directed production of 2D crystals of monoclonal antibodies at an antigen-phospholipid monolayer interface. The tetanus toxin crystals were formed using a small mole fraction of the natural receptor, GT1, incorporated into phosphatidyl choline monolayers. The crystals formed at low concentration overnight. Two dimensional crystals of this type are particularly useful for structure determination using electron microscopy and computer image refinement. Three dimensional (3D) structural information can be derived from these crystals by computer reconstruction of photographs of toxin crystals taken at different tilt angles. Such 3D reconstructions may help elucidate the mechanism of entry of the enzymatic subunit of toxins into cells, particularly since these crystals form directly on a membrane interface at similar concentrations of ganglioside GT1 to the natural cellular receptors.

Effect of halothane on neuromuscular transmission

JAMA ◽  
1966 ◽  
Vol 197 (10) ◽  
pp. 770-774 ◽  
Author(s):  
A. J. Gissen
Keyword(s):  
Neuromuscular Transmission
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