Antipituitary Antibodies in Patients with Lymphocytic Hypophysitis

2001 ◽  
Vol 55 (6) ◽  
pp. 288-292 ◽  
Author(s):  
Toshihiro Takao ◽  
Wakako Nanamiya ◽  
Reiko Matsumoto ◽  
Koichi Asaba ◽  
Tomoaki Okabayashi ◽  
...  
Keyword(s):  
Lymphocytic Hypophysitis ◽  
Antipituitary Antibodies

Recovery from lymphocytic hypophysitis associated with painless thyroiditis: clinical implications of circulating antipituitary antibodies

1993 ◽  
Vol 128 (6) ◽  
pp. 493-498 ◽  
Author(s):  
Yasunori Ozawa ◽  
Yoshimasa Shishiba
Keyword(s):  
Clinical Course ◽  
Lymphocytic Hypophysitis ◽  
Pituitary Function ◽  
Clinical Implications ◽  
Antipituitary Antibodies ◽  
Pituitary Dysfunction ◽  
Rat Pituitary ◽  
Circulating Antibodies ◽  
Painless Thyroiditis ◽  
Relationship Of

Lymphocytic hypophysitis usually occurs in the antepartum or postpartum period and recovery of pituitary dysfunction has not been documented in most cases reported previously. We present a 50-year-old woman with lymphocytic hypophysitis who spontaneously recovered from panhypopituitarism over 18 months with the disappearance of an intrasellar mass. Although lymphocytic hypophysitis is thought to be an autoimmune disease, the clinical and pathogenetic significance of circulating antipituitary autoantibodies has not been clarified. Antipituitary antibodies were studied by immunofluorescence in blood samples obtained during the whole clinical course in this particular patient. Antibodies against rat pituitary cytosol were positive during the period of hypopituitarism and became negative when pituitary function recovered. Antibodies reacting with intact prolactin-secreting rat GH3 and corticotropin-secreting mouse AtT-20 cells were also positive during her period of hypopituitarism. They remained positive for several years after the recovery of pituitary function. We conclude that circulating antibodies against rat pituitary cytosol are good markers of pituitary inflammation in this patient. The other point to be emphasized in this case is the simultaneous development of painless thyroiditis and lymphocytic hypophysitis. We have discussed the pathogenic relationship of these two diseases on the basis of similar cases reported previously.

Immunological and clinical aspects of lymphocytic hypophysitis

2008 ◽  
Vol 114 (6) ◽  
pp. 413-421 ◽  
Author(s):  
Annamaria De Bellis ◽  
Giuseppe Ruocco ◽  
Marina Battaglia ◽  
Marisa Conte ◽  
Concetta Coronella ◽  
...  
Keyword(s):  
Immune System ◽  
Autoimmune Disease ◽  
Pituitary Gland ◽  
Lymphocytic Hypophysitis ◽  
Clinical Aspects ◽  
Antipituitary Antibodies ◽  
Organ Specific ◽  
Pituitary Enlargement

LYH (lymphocytic hypophysitis) is an autoimmune disease of the pituitary gland which can present with varying degrees of pituitary hormonal impairment and/or with symptoms related to pituitary enlargement. In this review, we provide an overview of the epidemiology, diagnosis, pathogenesis, treatment, and the role of organ-specific and antipituitary antibodies as potential markers of LYH. In addition, although the mechanisms underlying LYH are not completely understood, the role of prolactin, which plays an important part in maintaining immune system homoeostasis and is increased in the disease, is considered.

The Ultrastructure of Lymphocytic Hypophysitis

1981 ◽  
Vol 39 ◽  
pp. 466-467
Author(s):  
S.L. Asa ◽  
K. Kovacs ◽  
J. M. Bilbao ◽  
R. G. Josse ◽  
K. Kreines
Keyword(s):  
Electron Microscopy ◽  
Plasma Cells ◽  
Secretory Granules ◽  
Sella Turcica ◽  
Uranyl Acetate ◽  
Lymphocytic Hypophysitis ◽  
Pituitary Cells ◽  
Transmission Electron ◽  
Ultrathin Sections ◽  
Mass Lesions

Seven cases of lymphocytic hypophysitis in women have been reported previously in association with various degrees of hypopituitarism. We report two pregnant patients who presented with mass lesions of the sella turcica, clinically mimicking pituitary adenoma. However, pathologic examination revealed extensive infiltration of the anterior pituitary by lymphocytes and plasma cells with destruction of the gland. To our knowledge, the ultrastructural features of lymphocytic hypophysitis have not been studied so far.For transmission electron microscopy, tissue from surgical specimens was fixed in glutaraldehyde, postfixed in OsO4, dehydrated and embedded in epoxy-resin. Ultrathin sections were stained with uranyl acetate and lead citrate and examined with a Philips 300 electron microscope.Electron microscopy revealed adenohypophysial cells of all types exhibiting varying degrees of injury. In the areas of most dense inflammatory cell infiltration pituitary cells contained large lysosomal bodies fusing with secretory granules (Fig. 1), as well as increased numbers of swollen mitochondria, indicating oncocytic transformation (Fig. 2).

Abstract #850 Lymphocytic Hypophysitis: Still a Diagnostic Challenge

2018 ◽  
Vol 24 ◽  
pp. 199
Author(s):  
Mumtaheena Miah ◽  
Puspalatha Sajja ◽  
Catherine Anastasopoulou ◽  
Nissa Blocher ◽  
Janna Prater
Keyword(s):  
Lymphocytic Hypophysitis ◽  
Diagnostic Challenge

scholarly journals Treatment of Lymphocytic Hypophysitis by High-Dose Methylprednisolone Pulse Therapy.

2003 ◽  
Vol 42 (2) ◽  
pp. 168-173 ◽  
Author(s):  
Keiko YAMAGAMI ◽  
Katsunobu YOSHIOKA ◽  
Haruna SAKAI ◽  
Mariko FUKUMOTO ◽  
Tetsuya YAMAKITA ◽  
...  
Keyword(s):  
Pulse Therapy ◽  
Lymphocytic Hypophysitis ◽  
Methylprednisolone Pulse Therapy ◽  
High Dose ◽  
Methylprednisolone Pulse ◽  
High Dose Methylprednisolone

scholarly journals A Case of Pituitary Germinoma Misdiagnosed as Lymphocytic Hypophysitis

2018 ◽  
Vol 8 (5) ◽  
pp. 113-118 ◽  
Author(s):  
Mohammad Ghorbani ◽  
Mahnaz Moradi ◽  
Mohammad Ebrahim Khamseh ◽  
Mojtaba Malek ◽  
Zahra Emami ◽  
...  
Keyword(s):  
Lymphocytic Hypophysitis

Lymphocytic hypophysitis: Report of an unusual case of a rare disorder

2001 ◽  
Vol 24 (3) ◽  
pp. 190-193 ◽  
Author(s):  
M. Durán Martínez ◽  
C. Santonja ◽  
I. Pavón de Paz ◽  
S. Monereo Megías
Keyword(s):  
Unusual Case ◽  
Lymphocytic Hypophysitis ◽  
Rare Disorder
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