scholarly journals A Case of Pituitary Germinoma Misdiagnosed as Lymphocytic Hypophysitis

2018 ◽  
Vol 8 (5) ◽  
pp. 113-118 ◽  
Author(s):  
Mohammad Ghorbani ◽  
Mahnaz Moradi ◽  
Mohammad Ebrahim Khamseh ◽  
Mojtaba Malek ◽  
Zahra Emami ◽  
...  
Keyword(s):  
Lymphocytic Hypophysitis

The Ultrastructure of Lymphocytic Hypophysitis

1981 ◽  
Vol 39 ◽  
pp. 466-467
Author(s):  
S.L. Asa ◽  
K. Kovacs ◽  
J. M. Bilbao ◽  
R. G. Josse ◽  
K. Kreines
Keyword(s):  
Electron Microscopy ◽  
Plasma Cells ◽  
Secretory Granules ◽  
Sella Turcica ◽  
Uranyl Acetate ◽  
Lymphocytic Hypophysitis ◽  
Pituitary Cells ◽  
Transmission Electron ◽  
Ultrathin Sections ◽  
Mass Lesions

Seven cases of lymphocytic hypophysitis in women have been reported previously in association with various degrees of hypopituitarism. We report two pregnant patients who presented with mass lesions of the sella turcica, clinically mimicking pituitary adenoma. However, pathologic examination revealed extensive infiltration of the anterior pituitary by lymphocytes and plasma cells with destruction of the gland. To our knowledge, the ultrastructural features of lymphocytic hypophysitis have not been studied so far.For transmission electron microscopy, tissue from surgical specimens was fixed in glutaraldehyde, postfixed in OsO4, dehydrated and embedded in epoxy-resin. Ultrathin sections were stained with uranyl acetate and lead citrate and examined with a Philips 300 electron microscope.Electron microscopy revealed adenohypophysial cells of all types exhibiting varying degrees of injury. In the areas of most dense inflammatory cell infiltration pituitary cells contained large lysosomal bodies fusing with secretory granules (Fig. 1), as well as increased numbers of swollen mitochondria, indicating oncocytic transformation (Fig. 2).

Abstract #850 Lymphocytic Hypophysitis: Still a Diagnostic Challenge

2018 ◽  
Vol 24 ◽  
pp. 199
Author(s):  
Mumtaheena Miah ◽  
Puspalatha Sajja ◽  
Catherine Anastasopoulou ◽  
Nissa Blocher ◽  
Janna Prater
Keyword(s):  
Lymphocytic Hypophysitis ◽  
Diagnostic Challenge

scholarly journals Treatment of Lymphocytic Hypophysitis by High-Dose Methylprednisolone Pulse Therapy.

2003 ◽  
Vol 42 (2) ◽  
pp. 168-173 ◽  
Author(s):  
Keiko YAMAGAMI ◽  
Katsunobu YOSHIOKA ◽  
Haruna SAKAI ◽  
Mariko FUKUMOTO ◽  
Tetsuya YAMAKITA ◽  
...  
Keyword(s):  
Pulse Therapy ◽  
Lymphocytic Hypophysitis ◽  
Methylprednisolone Pulse Therapy ◽  
High Dose ◽  
Methylprednisolone Pulse ◽  
High Dose Methylprednisolone

Lymphocytic hypophysitis: Report of an unusual case of a rare disorder

2001 ◽  
Vol 24 (3) ◽  
pp. 190-193 ◽  
Author(s):  
M. Durán Martínez ◽  
C. Santonja ◽  
I. Pavón de Paz ◽  
S. Monereo Megías
Keyword(s):  
Unusual Case ◽  
Lymphocytic Hypophysitis ◽  
Rare Disorder

Novel strategy to treat a case of recurrent lymphocytic hypophysitis using rituximab

2012 ◽  
Vol 116 (6) ◽  
pp. 1318-1323 ◽  
Author(s):  
Matthew Schreckinger ◽  
Todd Francis ◽  
Gary Rajah ◽  
Jay Jagannathan ◽  
Murali Guthikonda ◽  
...  
Keyword(s):  
B Cell ◽  
Lymphocytic Hypophysitis ◽  
Neurological Deficits ◽  
Sellar Mass ◽  
Short Course ◽  
Autoimmune Condition ◽  
Cd20 Antibody ◽  
Novel Strategy ◽  
Anti Cd20 ◽  
The Right

Lymphocytic hypophysitis is an uncommon autoimmune condition that often results in significant morbidity. Although most cases resolve spontaneously or after a short course of steroids, rarely, refractory cases can cause persistent neurological deficits despite aggressive medical and surgical management. A 41-year-old woman presented with progressive visual loss in the left eye and was found to have a sellar mass. She underwent transsphenoidal surgery because of lesion enlargement. Histopathology was consistent with adenohypophysitis with B-cell predominance. Despite steroid treatment, her neurological condition worsened and she experienced loss of vision in the right eye. Craniotomy with decompression of the right optic nerve was performed. Her condition improved initially, but she continued to have progressive visual compromise over the following months. She was therefore treated with rituximab, a monoclonal antibody against B cells. Her vision improved significantly within a few weeks. There was no clinical or radiographic exacerbation 2 years after starting immunotherapy. Rituximab, an anti-CD20 antibody that specifically depletes B lymphocytes, can be an effective treatment strategy for patients with steroid-refractory, B cell–predominant lymphocytic hypophysitis.

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