scholarly journals Two Cases of Sinonasal Non-Intestinal-Type Adenocarcinoma with Squamoid Morules Expressing Nuclear β-Catenin and CDX2: A Curious Morphologic Finding Supported by Molecular Analysis

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Tatiana M. Villatoro ◽  
Stacey K. Mardekian
Keyword(s):  
Head And Neck ◽  
Molecular Analysis ◽  
Underlying Mechanism ◽  
Intestinal Type ◽  
Low Grade ◽  
Gene Encoding ◽  
Aberrant Expression ◽  
Nuclear Expression ◽  
Intestinal Type Adenocarcinoma

Sinonasal non-intestinal-type adenocarcinoma (non-ITAC) is a rare, morphologically diverse neoplasm of the head and neck. Squamoid morular metaplasia has recently been reported as an occasional finding in non-ITAC. Interestingly, these squamoid morules often show aberrant expression of CDX2 as well as nuclear expression of β-catenin, similar to other tumors that show this type of metaplasia, but the underlying mechanism responsible for this finding is not completely understood. We present two cases of low-grade non-ITAC with squamoid morules coexpressing CDX2 and nuclear β-catenin by immunohistochemistry, both of which were found to harbor a mutation in CTNNB1, the gene encoding β-catenin. This finding provides support that an alteration in the β-catenin pathway, including mutations in the β-catenin gene itself, is responsible for this recently described morphologic phenomenon in non-ITAC.

scholarly journals TP53 , p14 ARF , p16 INK4a and H-ras gene molecular analysis in intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses

2003 ◽  
Vol 105 (2) ◽  
pp. 196-203 ◽  
Author(s):  
Federica Perrone ◽  
Maria Oggionni ◽  
Sarah Birindelli ◽  
Simona Suardi ◽  
Silvia Tabano ◽  
...  
Keyword(s):  
Nasal Cavity ◽  
Molecular Analysis ◽  
Paranasal Sinuses ◽  
Intestinal Type ◽  
Ras Gene ◽  
Intestinal Type Adenocarcinoma ◽  
P16 Ink4a

ETV6 Gene Rearrangements Characterize a Morphologically Distinct Subset of Sinonasal Low-grade Non–intestinal-type Adenocarcinoma

2017 ◽  
Vol 41 (11) ◽  
pp. 1552-1560 ◽  
Author(s):  
Simon Andreasen ◽  
Alena Skálová ◽  
Abbas Agaimy ◽  
Justin A. Bishop ◽  
Jan Laco ◽  
...  
Keyword(s):  
Intestinal Type ◽  
Low Grade ◽  
Gene Rearrangements ◽  
Distinct Subset ◽  
Intestinal Type Adenocarcinoma

A case of nasal low-grade non-intestinal-type adenocarcinoma with aberrant CDX2 expression and a novel SYN2-PPARG gene fusion in a 13-year-old girl

2019 ◽  
Vol 474 (5) ◽  
pp. 619-623 ◽  
Author(s):  
Gwyneth Shook Ting Soon ◽  
Kenneth Tou En Chang ◽  
Chik Hong Kuick ◽  
Fredrik Petersson
Keyword(s):  
Gene Fusion ◽  
Intestinal Type ◽  
Low Grade ◽  
Cdx2 Expression ◽  
Pparg Gene ◽  
Intestinal Type Adenocarcinoma

scholarly journals Glyoxalase I disruption and external carbonyl stress impair mitochondrial function in human induced pluripotent stem cells and derived neurons

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tomonori Hara ◽  
Manabu Toyoshima ◽  
Yasuko Hisano ◽  
Shabeesh Balan ◽  
Yoshimi Iwayama ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Caspase 3 ◽  
Intervention Strategy ◽  
Underlying Mechanism ◽  
Carbonyl Stress ◽  
Gene Encoding ◽  
Induced Pluripotent

AbstractCarbonyl stress, a specific form of oxidative stress, is reported to be involved in the pathophysiology of schizophrenia; however, little is known regarding the underlying mechanism. Here, we found that disruption of GLO1, the gene encoding a major catabolic enzyme scavenging the carbonyl group, increases vulnerability to external carbonyl stress, leading to abnormal phenotypes in human induced pluripotent stem cells (hiPSCs). The viability of GLO1 knockout (KO)-hiPSCs decreased and activity of caspase-3 was increased upon addition of methylglyoxal (MGO), a reactive carbonyl compound. In the GLO1 KO-hiPSC-derived neurons, MGO administration impaired neurite extension and cell migration. Further, accumulation of methylglyoxal-derived hydroimidazolone (MG-H1; a derivative of MGO)-modified proteins was detected in isolated mitochondria. Mitochondrial dysfunction, including diminished membrane potential and dampened respiratory function, was observed in the GLO1 KO-hiPSCs and derived neurons after addition of MGO and hence might be the mechanism underlying the effects of carbonyl stress. The susceptibility to MGO was partially rescued by the administration of pyridoxamine, a carbonyl scavenger. Our observations can be used for designing an intervention strategy for diseases, particularly those induced by enhanced carbonyl stress or oxidative stress.

scholarly journals Immunohistochemical Biomarkers as a Surrogate of Molecular Analysis in Ovarian Carcinomas: A Review of the Literature

Diagnostics ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 199 ◽  
Author(s):  
Giacomo Santandrea ◽  
Simonetta Piana ◽  
Riccardo Valli ◽  
Magda Zanelli ◽  
Elisa Gasparini ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
Molecular Analysis ◽  
Immunohistochemical Analysis ◽  
Cost Effective ◽  
Mucinous Carcinoma ◽  
Serous Carcinoma ◽  
Malignant Neoplasms ◽  
Low Grade ◽  
Ovarian Carcinomas ◽  
Novel Target

The term “ovarian carcinoma” encompasses at least five different malignant neoplasms: high-grade serous carcinoma, low-grade serous carcinoma, endometrioid carcinoma, mucinous carcinoma, and clear cell carcinoma. These five histotypes demonstrated distinctive histological, molecular, and clinical features. The rise of novel target therapies and of a tailored oncological approach has demanded an integrated multidisciplinary approach in the setting of ovarian carcinoma. The need to implement a molecular-based classification in the worldwide diagnostic and therapeutic setting of ovarian cancer demanded a search for easy-to-use and cost-effective molecular-surrogate biomarkers, relying particularly on immunohistochemical analysis. The present review focuses on the role of immunohistochemistry as a surrogate of molecular analysis in the everyday diagnostic approach to ovarian carcinomas.

scholarly journals Head and Neck Rhabdomyosarcoma Harboring TFCP2 Fusions and ALK overexpression: A Clinicopathologic and Molecular Analysis of 11 cases

2020 ◽  
Author(s):  
Bin Xu ◽  
Albert JH Suurmeijer ◽  
Narasimhan P Agaram ◽  
Lei Zhang ◽  
Cristina R. Antonescu
Keyword(s):  
Head And Neck ◽  
Molecular Analysis

scholarly journals Biochemical and Molecular Analysis of Pink Tomatoes: Deregulated Expression of the Gene Encoding Transcription Factor SlMYB12 Leads to Pink Tomato Fruit Color

2009 ◽  
Vol 152 (1) ◽  
pp. 71-84 ◽  
Author(s):  
Ana-Rosa Ballester ◽  
Jos Molthoff ◽  
Ric de Vos ◽  
Bas te Lintel Hekkert ◽  
Diego Orzaez ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Molecular Analysis ◽  
Tomato Fruit ◽  
Fruit Color ◽  
Gene Encoding
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