scholarly journals Head and Neck Rhabdomyosarcoma Harboring TFCP2 Fusions and ALK overexpression: A Clinicopathologic and Molecular Analysis of 11 cases

2020 ◽  
Author(s):  
Bin Xu ◽  
Albert JH Suurmeijer ◽  
Narasimhan P Agaram ◽  
Lei Zhang ◽  
Cristina R. Antonescu
Keyword(s):  
Head And Neck ◽  
Molecular Analysis

scholarly journals Two Cases of Sinonasal Non-Intestinal-Type Adenocarcinoma with Squamoid Morules Expressing Nuclear β-Catenin and CDX2: A Curious Morphologic Finding Supported by Molecular Analysis

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Tatiana M. Villatoro ◽  
Stacey K. Mardekian
Keyword(s):  
Head And Neck ◽  
Molecular Analysis ◽  
Underlying Mechanism ◽  
Intestinal Type ◽  
Low Grade ◽  
Gene Encoding ◽  
Aberrant Expression ◽  
Nuclear Expression ◽  
Intestinal Type Adenocarcinoma

Sinonasal non-intestinal-type adenocarcinoma (non-ITAC) is a rare, morphologically diverse neoplasm of the head and neck. Squamoid morular metaplasia has recently been reported as an occasional finding in non-ITAC. Interestingly, these squamoid morules often show aberrant expression of CDX2 as well as nuclear expression of β-catenin, similar to other tumors that show this type of metaplasia, but the underlying mechanism responsible for this finding is not completely understood. We present two cases of low-grade non-ITAC with squamoid morules coexpressing CDX2 and nuclear β-catenin by immunohistochemistry, both of which were found to harbor a mutation in CTNNB1, the gene encoding β-catenin. This finding provides support that an alteration in the β-catenin pathway, including mutations in the β-catenin gene itself, is responsible for this recently described morphologic phenomenon in non-ITAC.

Molecular Analysis of Surgical Margins in Head and Neck Squamous Cell Carcinoma Patients

2002 ◽  
Vol 112 (12) ◽  
pp. 2129-2140 ◽  
Author(s):  
Cherie-Ann O. Nathan ◽  
Nazanin Amirghahri ◽  
Cliff Rice ◽  
Fleurette W. Abreo ◽  
Runhua Shi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Molecular Analysis ◽  
Squamous Cell ◽  
Surgical Margins ◽  
Neck Squamous Cell Carcinoma

Familial Head and Neck Cancer: Molecular Analysis of a New Clinical Entity

2002 ◽  
Vol 112 (9) ◽  
pp. 1587-1593 ◽  
Author(s):  
Kathy K. Yu ◽  
Adam M. Zanation ◽  
Jonathan R. Moss ◽  
Wendell G. Yarbrough
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Molecular Analysis ◽  
Neck Cancer ◽  
Clinical Entity

scholarly journals The role of molecular strategies in the evaluation of surgical margins in oropharyngeal squamous cell carcinoma

2011 ◽  
Vol 2 (2) ◽  
pp. 161
Author(s):  
Anastasios N. Kanatas ◽  
Andrew T. Harris ◽  
Michael Messenger ◽  
David Houghton ◽  
Simon N. Rogers
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Molecular Analysis ◽  
Squamous Cell ◽  
Treatment Strategy ◽  
Resection Margins ◽  
Conflicting Evidence ◽  
Review Current

The recurrence of a tumour at the resection margins in head and neck squamous cell carcinoma (HNSCC) has profound implications on the morbidity and mortality of the patient. At present HNSCC does not undergo any form of molecular analysis to aid treatment strategy and prognosticate for those individuals at higher risk of recurrence. This article aims to review current research into molecular strategies for tumour evaluation, highlighting conflicting evidence and possible novel concepts for further exploration.

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