scholarly journals Incidentally Detected Kaposi Sarcoma of Adrenal Gland with Anaplastic Features in an HIV Negative Patient

2016 ◽  
Vol 2016 ◽  
pp. 1-5
Author(s):  
Zeliha Esin Celik ◽  
Murat Celik ◽  
Erdem Sen ◽  
Hakan Cebeci ◽  
Ozlem Ata ◽  
...  
Keyword(s):  
Adrenal Gland ◽  
Systemic Disease ◽  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Metastatic Potential ◽  
Cutaneous Lesions ◽  
Negative Patient ◽  
First Case ◽  
Anaplastic Transformation ◽  
Hiv Negative

Kaposi sarcoma (KS), a vascular tumor caused by infection with human herpesvirus 8 (HHV8), is a systemic disease that can present with cutaneous lesions with or without visceral involvement. Very few cases of KS, most of which were associated with AIDS, have been reported in the adrenal gland. Anaplastic transformation of KS is a rare clinical presentation known as an aggressive disease with local recurrence and metastatic potential. We report here a 47-year-old HIV negative male presented with extra-adrenal symptoms and had an incidentally detected anaplastic adrenal KS exhibited aggressive clinical course. To the best of our knowledge, this is the first case of anaplastic primary adrenal KS without mucocutaneous involvement but subsequently developed other side adrenal metastases in an HIV negative patient.

scholarly journals Maxillary Sinus Kaposi Sarcoma: Case Report in an HIV-Negative Patient with Thymoma

2017 ◽  
Vol 2017 ◽  
pp. 1-3
Author(s):  
Bernardo Carvalho Araújo ◽  
Sara Viana Baptista ◽  
Luís Mascarenhas ◽  
Ezequiel Barros
Keyword(s):  
Case Report ◽  
Maxillary Sinus ◽  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Negative Patient ◽  
Herpesvirus 8 ◽  
The Right ◽  
Clinical Records ◽  
Careful Investigation ◽  
Hiv Negative

Introduction. Kaposi sarcoma is an angioproliferative disorder that requires infection with human herpesvirus 8 (HHV-8) for its development. The majority of cases are associated with HIV infection or other immunocompromising conditions. Thymomas are occasionally associated to cytopenia, which may alter the patients’ immune responses. Methods. Case report using clinical records. Results. Case report of a 46-year-old male patient diagnosed with thymoma and myasthenia gravis. The patient was referred to an otolaryngology consultation with complaints of facial pain in the right malar region, interpreted as an acute sinusitis. Following examination, an expansive maxillary sinus mass was found, and endoscopic surgery was undertaken. After careful investigation, it was diagnosed as a Kaposi sarcoma. Conclusions. It is thought to be the first described case of a maxillary sinus Kaposi sarcoma in an HIV-negative patient. Thus, this entity has to be considered in the differential diagnosis of sinus masses, even in non-HIV patients.

Kaposi Sarcoma in an HIV-Negative Patient

2018 ◽  
Vol 126 (3) ◽  
pp. e45
Author(s):  
Aline Fernanda Cruz ◽  
José Augusto Dias Araújo ◽  
Samuel Macedo Costa ◽  
Júlio César Tanos De Lacerda ◽  
Patrícia Carlos Caldeira ◽  
...  
Keyword(s):  
Kaposi Sarcoma ◽  
Negative Patient ◽  
Hiv Negative

Tonsillar Kaposi sarcoma in an HIV-negative patient

AIDS ◽  
2019 ◽  
Vol 33 (7) ◽  
pp. 1263-1264 ◽  
Author(s):  
Alessandra Latini ◽  
Lavinia Alei ◽  
Renato Covello ◽  
Antonio Cristaudo ◽  
Manuela Colafigli ◽  
...  
Keyword(s):  
Kaposi Sarcoma ◽  
Negative Patient ◽  
Hiv Negative

A Case of Kaposi’s Sarcoma in a HIV Negative Patient with CLL Treated with Rituximab

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 4970-4970
Author(s):  
Anuradha Avinash Belur ◽  
Arun Kumar Arumugam Raajasekar ◽  
Srikant Nannapaneni ◽  
Thandavababu Chelliah
Keyword(s):  
Kaposi's Sarcoma ◽  
Conflicts Of Interest ◽  
Kaposi Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Skin Lesions ◽  
Elisa Test ◽  
Lymphocytic Leukemia ◽  
Cell Mediated Immunity ◽  
Negative Patient ◽  
Hiv Negative

Abstract Case Description: - A 76 year old lady was diagnosed with Chronic Lymphocytic Leukemia (CLL) with 11 q deletion after she presented with generalized lymphadenopathy and anemia. She was treated with rituximab 375mg/m2 day1 and bendamustine 60mg/m2 on day 1 and day 2 and completed six cycles of treatment. After the sixth cycle she developed multiple itchy, papular lesions with bleeding on both lower extremities. She was evaluated multiple times by vascular surgery and dermatology without a definitive diagnosis. She underwent a biopsy with staining for HHV-8, CD31 and CD34 which was positive confirming the diagnosis of Kaposi sarcoma. ELISA test for HIV was negative. She was started on treatment with Doxorubicin 20 mg/m2every 3 weeks and with 3 cycles there was significant regression of the lesions. Discussion-: We describe a case of CLL which was initially started on treatment with rituximab and bendamustine. She tolerated the treatment well, but a few months later presented with skin lesions which on biopsy was diagnosed as Kaposi sarcoma. It is very uncommon for Kaposi sarcoma to develop in a HIV negative patient. This patient was immunocompromised with recent chemotherapy. Rituximab specifically depletes B cells and leads to impaired T cell mediated immunity. This case illustrates the importance of a high index of suspicion in patients treated with rituximab as it is used for a number of hematologic malignancies like leukemia, lymphoma as well as non-malignant conditions like autoimmune disorders. While infusion reactions and reactivation of hepatitis B are side effects physicians are aware of and cautious of while using rituximab, Kaposi’s Sarcoma remains a less known side effect. Awareness of this possibility is important in physicians prescribing rituximab. Footnotes * Asterisk with author names denotes non-ASH members. Disclosures No relevant conflicts of interest to declare.

Genetically Determined Coincidence of Kaposi Sarcoma and Psoriasis in an HIV-Negative Patient After Prednisolone Treatment.

1991 ◽  
Vol 30 (2) ◽  
pp. 114-120 ◽  
Author(s):  
Beate Tebbe ◽  
Augusto Mayer-da-Silva ◽  
C. Garbe ◽  
Hans-Joachim Keyserlingk ◽  
Constantin E. Orfanos
Keyword(s):  
Kaposi Sarcoma ◽  
Negative Patient ◽  
Prednisolone Treatment ◽  
Genetically Determined ◽  
Hiv Negative

Primary Penile Kaposi Sarcoma in an HIV-negative 21-year-old Male

2014 ◽  
Vol 10 (02) ◽  
pp. 2
Author(s):  
Sophie Momen ◽  
Cathy Corbishley ◽  
Ruth Pettengell ◽  
Ben Ayres ◽  
Jens Samol ◽  
...  
Keyword(s):  
Clinical Evidence ◽  
Sexual Transmission ◽  
Kaposi Sarcoma ◽  
Human Herpes Virus 8 ◽  
Human Herpes Virus ◽  
First Case ◽  
Local Surgery ◽  
Complete Clinical Remission ◽  
History Of ◽  
Hiv Negative

We present a 21-year-old HIV-negative Somalian male who was diagnosed with an immunohistochemically proven human herpes virus 8 (HHV8)-positive primary penile Karposi’s Sarcoma (KS). He was treated with local surgery and remained in complete clinical remission for 18 months. This is the first case of a heterosexual teenage and young adult (TYA) patient diagnosed with a primary penile KS without a history of sexual intercourse. This case provides clinical evidence that KS may be transmitted through routes other than sexual transmission.

Pyogenic granuloma-like Kaposi sarcoma presenting in an HIV-negative man who has sex with men

2020 ◽  
Vol 13 (11) ◽  
pp. e237420
Author(s):  
Bernard Ho ◽  
Giulia Rinaldi ◽  
Imran Khan ◽  
Susanna Szakacs
Keyword(s):  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Pyogenic Granuloma ◽  
Herpesvirus 8 ◽  
Dermatology Clinic ◽  
Spindle Cell Proliferation ◽  
Sex With Men ◽  
The Right ◽  
Intermittent Bleeding ◽  
Hiv Negative

A 36-year-old immunocompetent man who have sex with men first presented to the plastics team with an ulcerating lesion on his left first toe. The lesion was suggestive of pyogenic granuloma (PG) clinically and histologically. Two years later, the same patient presented to the dermatology clinic with a new erythematous lesion with intermittent bleeding on the left second toe. Clinically, this lesion was suggestive of another PG. However, the histology of the skin curettage revealed part of a PG merging with an atypical spindle cell proliferation with characteristic ‘sieve-like’ appearance in keeping with Kaposi sarcoma. This was confirmed with human herpesvirus-8 immunohistochemistry staining. PG-like Kaposi sarcoma is an uncommon variant of Kaposi sarcoma. Often not considered clinically or histologically, a deep skin biopsy is essential to establish the right diagnosis. Our case highlights the need to consider Kaposi sarcoma as a differential diagnosis in all patients, including HIV-negative individuals, presenting with PG-like lesions.

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