Successful treatment and durable remission of human herpesvirus‐8‐induced Kaposi sarcoma and multicentric Castleman's disease under valganciclovir in an HIV ‐negative patient

2020 ◽  
Vol 33 (3) ◽  
Author(s):  
Kerasia‐Maria Plachouri ◽  
Chrysa Oikonomou ◽  
Angelos Sarantopoulos ◽  
Dimitra Koumoundourou ◽  
Sophia Georgiou ◽  
...  
Keyword(s):  
Successful Treatment ◽  
Castleman’S Disease ◽  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Human Herpesvirus 8 ◽  
Negative Patient ◽  
Herpesvirus 8 ◽  
Multicentric Castleman's Disease ◽  
Durable Remission ◽  
Hiv Negative

scholarly journals Human Herpesvirus-8 Infection Associated with Kaposi Sarcoma, Multicentric Castleman's Disease, and Plasmablastic Microlymphoma in a Man with AIDS: A Case Report with Review of Pathophysiologic Processes

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Christian Eaton ◽  
Russell Dorer ◽  
David M. Aboulafia
Keyword(s):  
Lymph Node ◽  
Highly Active Antiretroviral Therapy ◽  
Castleman’S Disease ◽  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Human Herpesvirus 8 ◽  
Castleman's Disease ◽  
Multicentric Castleman’S Disease ◽  
Herpesvirus 8 ◽  
Multicentric Castleman's Disease

Kaposi sarcoma (KS), multicentric Castleman's disease (MCD), and plasmablastic microlymphoma, are all linked to human herpesvirus-8 (HHV-8) infection and HIV-induced immunodeficiency. Herein, we describe the case of a Kenyan man diagnosed with HIV in 2000. He deferred highly active antiretroviral therapy (HAART) and remained in good health until his CD4+ count declined in 2006. He was hospitalized with bacterial pneumonia in 2008, after which he agreed to take HAART but did so sporadically. In 2010, he was hospitalized with fever, lymphadenopathy, pancytopenia, and an elevated HHV-8 viral load. A lymph node biopsy showed findings consistent with KS, MCD, and plasmablastic microlymphoma. Eight months after starting liposomal doxorubicin, Rituximab, and a new HAART regimen, he has improved clinically, and his HIV and HHV-8 viral loads are suppressed. These three conditions, found in the same lymph node, underscore the inflammatory and malignant potential of HHV-8, particularly in the milieu of HIV-induced immunodeficiency.

Practical Management of Castleman's Disease

2016 ◽  
Vol 136 (1) ◽  
pp. 16-22
Author(s):  
Musa Fares Alzahrani ◽  
Mansoor Radwi ◽  
Heather A. Leitch
Keyword(s):  
Hiv Infection ◽  
Interleukin 6 ◽  
Lymphoproliferative Disorder ◽  
Treatment Options ◽  
Castleman’S Disease ◽  
Human Herpesvirus ◽  
Human Herpesvirus 8 ◽  
Castleman's Disease ◽  
Herpesvirus 8 ◽  
Hiv Negative

Castleman's disease (CD) is a rare lymphoproliferative disorder that is most commonly present in multicentric (MCD) form in association with HIV infection. Interleukin-6 (IL-6) and human herpesvirus-8 (HHV-8) play major roles in MCD pathogenesis. Important treatment options have recently become available, particularly with the introduction of IL-6 and IL-6 receptor inhibitors for the treatment of HIV-negative patients with MCD. Though advances in therapy may improve outcomes in some patients, the prognosis remains guarded, and a stratified approach to the management of MCD is needed.

scholarly journals Maxillary Sinus Kaposi Sarcoma: Case Report in an HIV-Negative Patient with Thymoma

2017 ◽  
Vol 2017 ◽  
pp. 1-3
Author(s):  
Bernardo Carvalho Araújo ◽  
Sara Viana Baptista ◽  
Luís Mascarenhas ◽  
Ezequiel Barros
Keyword(s):  
Case Report ◽  
Maxillary Sinus ◽  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Negative Patient ◽  
Herpesvirus 8 ◽  
The Right ◽  
Clinical Records ◽  
Careful Investigation ◽  
Hiv Negative

Introduction. Kaposi sarcoma is an angioproliferative disorder that requires infection with human herpesvirus 8 (HHV-8) for its development. The majority of cases are associated with HIV infection or other immunocompromising conditions. Thymomas are occasionally associated to cytopenia, which may alter the patients’ immune responses. Methods. Case report using clinical records. Results. Case report of a 46-year-old male patient diagnosed with thymoma and myasthenia gravis. The patient was referred to an otolaryngology consultation with complaints of facial pain in the right malar region, interpreted as an acute sinusitis. Following examination, an expansive maxillary sinus mass was found, and endoscopic surgery was undertaken. After careful investigation, it was diagnosed as a Kaposi sarcoma. Conclusions. It is thought to be the first described case of a maxillary sinus Kaposi sarcoma in an HIV-negative patient. Thus, this entity has to be considered in the differential diagnosis of sinus masses, even in non-HIV patients.

scholarly journals Atypical Manifestations in Classic Kaposi Sarcoma: Case Series of Two Patients HIV - Negative

2019 ◽  
Vol 7 (6) ◽  
pp. 1021-1024 ◽  
Author(s):  
Tiziana Peduto ◽  
Francesco Cillo ◽  
Paola Nappa ◽  
Mario Delfino ◽  
Gabriella Fabbrocini ◽  
...  
Keyword(s):  
Case Series ◽  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Skin Lesions ◽  
Human Herpesvirus 8 ◽  
Herpesvirus 8 ◽  
Atypical Manifestations ◽  
Classic Kaposi Sarcoma ◽  
Prompt Diagnosis ◽  
Hiv Negative

BACKGROUND: Kaposi's sarcoma (KS) is a tumour of endothelial, blood and lymphatic cells, caused by an infection with human herpesvirus-8 (HHV-8). The skin lesions of KS, especially of the classical or Mediterranean variant (CKS), are represented by red-purple macules, plaques and nodules, localised mainly on the extremities. CASE REPORT: This case series intend to describe multifocal atypical kaposian manifestations in two HIV negative subjects, affected by CKS, treated with successful chemotherapy. CONCLUSIONS: Although atypical manifestations are extremely rare events, we suggest an accurate, objective examination because a prompt diagnosis can lead to a vital intervention in the patient's health and sometimes to the identification of the disease itself.

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