scholarly journals Coexistence of Ankylosing Spondylitis and Löfgren’s Syndrome

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Senol Kobak ◽  
Fidan Sever ◽  
Oya Sivrikoz ◽  
Ahmet Karaarslan
Keyword(s):  
Ankylosing Spondylitis ◽  
Low Dose ◽  
Histopathological Examination ◽  
Skin Lesions ◽  
Lymph Node Biopsy ◽  
Node Biopsy ◽  
Löfgren’S Syndrome ◽  
Significant Regression ◽  
Dose Corticosteroid ◽  
Thorax Ct

A 46-year-old male patient diagnosed with ankylosing spondylitis presented to our polyclinic with complaints of pain, swelling, and limitation in joint mobility in both ankles and erythema nodosum skin lesions in both pretibial sites. The sacroiliac joint graphy and the MRI taken revealed active and chronic sacroiliitis. On the thorax CT, multiple mediastinal and hilar lymphadenopathies were reported. Mediastinoscopic excisional lymph node biopsy was taken and noncalcified granulomatous structures, lymphocytes, and histiocytes were determined on histopathological examination. The patients were diagnosed with ankylosing spondylitis, sarcoidosis, and Löfgren’s syndrome. NSAIDs, sulfasalazine, and low dose corticosteroid were started. Significant regression was seen in the patient’s subjective and laboratory assessments.

scholarly journals Sentinel bruising as a presentation of metastatic melanoma

2019 ◽  
Vol 12 (2) ◽  
pp. e228114 ◽  
Author(s):  
Lloyd Steele ◽  
Chit Cheng Yeoh
Keyword(s):  
Weight Loss ◽  
Skin Lesions ◽  
Lymph Node Biopsy ◽  
Cutaneous Malignant Melanoma ◽  
Subcutaneous Nodule ◽  
Rare Presentation ◽  
Subcutaneous Nodules ◽  
Node Biopsy ◽  
Melanoma Metastases ◽  
History Of

A 46-year-old man presented with a 4-week history of bruising with subcutaneous nodules and weight loss. He also had a 2-week history of progressive back and hip pain. He had been diagnosed with stage Ib cutaneous melanoma 30 months previously, which had been fully excised. A sentinel lymph node biopsy was negative. On examination, there were five skin lesions at different stages. Each had spontaneously appeared as a bruise with a central subcutaneous nodule, and the bruising then faded to leave a persistent subcutaneous nodule. Excision of one of the nodules demonstrated a 4.5 mm diameter partly necrotic melanoma deposit in the dermis. CT scan of the head, chest, abdomen and pelvis showed widespread metastases. This rare presentation of cutaneous malignant melanoma metastases has been termed ‘sentinel bruising’. There are fewer than 10 cases reported in the literature.

Staging N0 oral cancer: lymphoscintigraphy and conventional imaging

2005 ◽  
Vol 46 (5) ◽  
pp. 492-496 ◽  
Author(s):  
J. B. Thomsen ◽  
J. A. Sørensen ◽  
P. Grupe ◽  
J. Karstoft ◽  
A. Krogdahl
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Oral Cavity ◽  
Doppler Ultrasonography ◽  
Histopathological Examination ◽  
Lymph Node Biopsy ◽  
Predictive Values ◽  
Node Biopsy ◽  
Neck Disease

Purpose: To compare sentinel lymph node biopsy, magnetic resonance imaging (MRI), Doppler ultrasonography, and palpation as staging tools in patients with T1/T2 N0 cancer of the oral cavity. Material and Methods: Forty consecutive patients were enrolled (17 F and 23 M, aged 32–90 years), 24 T1 and 16 T2 cN0 squamous cell carcinoma of the oral cavity. Palpation was carried out by two observers prior to inclusion. MRI, gray-scale and Doppler ultrasonography were performed. Lymphoscintigraphies were done after peritumoral injections of 99mTc labelled rheniumsulphide nanocolloid, followed by sentinel lymph node biopsy guided by a gamma probe and Patent Blue. Palpation, Doppler ultrasonography, MRI, and sentinel lymph node biopsy were compared to a combination of histopathology and follow-up. Diagnostic testing was performed using the x2 test. Results: Histopathological examination revealed metastatic spread to the neck in 14 of 40 patients. One patient had bilateral neck disease. Sentinel lymph node biopsy and ultrasonography were performed in 80 neck sides of 40 patients and MRI in 70 neck sides (5 patients were claustrophobic). SN revealed suspicious lymph nodes in 12 necks, ultrasonography in 23 necks, and MRI in 9 necks. The positive predictive value of sentinel lymph node biopsy was 100%, ultrasonography 57%, and MRI 56%. The respective negative predictive values were 96%, 96%, and 85%. The sensitivity of sentinel lymph node biopsy 80% was comparable to ultrasonography 87%, but the sensitivity of MRI 36% was low. The specificities were 100%, 85%, and 93%, respectively. By combined sentinel lymph node biopsy and ultrasonography the overall sensitivity could have been 100%. Conclusion: Sentinel lymph node biopsy improved staging of patients with small N0 oral cancers. Combined sentinel lymph node biopsy and Doppler ultrasonography may further improve staging. MRI and simple palpation results were poor.

scholarly journals Sentinel lymph node biopsy in pregnancy-associated breast cancer

2013 ◽  
Vol 154 (50) ◽  
pp. 1991-1997 ◽  
Author(s):  
Zoltán Mátrai ◽  
Ferenc Bánhidy ◽  
Melinda Téglás ◽  
Eszter Kovács ◽  
Ákos Sávolt ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Low Dose ◽  
Lymph Node Biopsy ◽  
Blue Dye ◽  
Breast Cancer Patients ◽  
Node Biopsy ◽  
Axillary Lymphadenectomy

The incidence of pregnancy-associated breast cancer is rising. Sentinel lymph node biopsy is the method of choice in clinically node negative cases as the indicated minimally invasive regional staging procedure. Some reports have linked radioisotope and blue dye required for lymphatic mapping to teratogenic effects, the idea of which has become a generalized statement and, until recently, contraindication for these agents was considered during pregnancy. Today, there are many published reports of successful interventions with low-dose 99mTc-labeled human albumin nanocolloid, based on dosimetric modeling demonstrating a negligible radiation exposure of the fetus. These results contributed to the seemingly safe and successful use of sentinel lymph node biopsy during pregnancy, though generally it can not replace axillary lymphadenectomy in the absence of high-quality evidence. The possibility of sentinel lymph node biopsy should be offered to pregnancy-associated early breast cancer patients with clinically negative axilla, and patients should be involved in the decision making following extensive counselling. This paper presents the successful use of sentinel lymph node biopsy with low-dose tracer during two pregnancies (in the first and third trimesters) and, for the first time in Hungarian language, it offers a comprehensive literature review on this topic. Orv. Hetil., 154(50), 1991–1997.

scholarly journals M. tuberculosisin Lymph Node Biopsy Paraffin-Embedded Sections

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Abdurehman Eshete ◽  
Ahmed Zeyinudin ◽  
Solomon Ali ◽  
Solomon Abera ◽  
Mona Mohammed
Keyword(s):  
Lymph Node ◽  
Histopathological Examination ◽  
Extrapulmonary Tuberculosis ◽  
Staining Technique ◽  
Cross Sectional Study ◽  
Lymph Node Biopsy ◽  
Medical Laboratory ◽  
Cross Sectional ◽  
Node Biopsy ◽  
Nodal Tissue

Background. Tuberculosis lymphadenitis is one of the most common forms of all extrapulmonary tuberculosis.Objective. To evaluate the magnitude ofM. tuberculosisfrom lymph node biopsy paraffin-embedded sections among suspected patients visiting the Jimma University Specialized Hospital.Method. A cross-sectional study design of histological examination among lymph node biopsy paraffin-embedded sections by Ziehl-Neelsen and hematoxylin/eosin staining technique was conducted from December, 2009, to October, 2010, at the Department of Medical Laboratory Science and Pathology.Result. Histopathological examination of the specimens by hematoxylin and eosin staining technique revealed the presence of granulomas. But for the caseation and necrosis they were present in 85% cases of nodal tissue biopsies. From those, 56.7% were from females. The presence of acid-fast bacilli was microscopically confirmed by ZN staining in 37 (61.7%) of the nodal tissue biopsies.Conclusion and Recommendation. Tuberculosis lymphadenitis is significantly more common in females. Hence, attention should be given for control and prevention of extrapulmonary tuberculosis.

Myoclonus in patient on fluoxetine after receiving fentanyl and low-dose methylene blue during sentinel lymph node biopsy

2015 ◽  
Vol 27 (3) ◽  
pp. 247-251 ◽  
Author(s):  
Kelly J. Larson ◽  
Erica D. Wittwer ◽  
Wayne T. Nicholson ◽  
Toby N. Weingarten ◽  
Daniel L. Price ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Low Dose ◽  
Lymph Node Biopsy ◽  
Node Biopsy

Rosai-Dorfman disease of the larynx

2000 ◽  
Vol 114 (7) ◽  
pp. 565-567 ◽  
Author(s):  
P. Aluffi ◽  
A. Prestinari ◽  
A. Ramponi ◽  
M. Castri ◽  
F. Pia
Keyword(s):  
Histopathological Examination ◽  
Lymph Node Biopsy ◽  
Massive Lymphadenopathy ◽  
Submandibular Lymph Node ◽  
Node Biopsy ◽  
Previous Diagnosis ◽  
Rosai Dorfman Disease ◽  
History Of ◽  
Laser Excision ◽  
Modest Reduction

We present a case of an 81-year-old man with a history of worsening dysphonia of six months duration. A year before a sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) was diagnosed on a submandibular lymph node biopsy. On presentation the patient showed a mass in the left subglottic area with a modest reduction in the airway space. The patient underwent an endoscopic CO2 laser excision of the mass, without post-operative complications. Histopathological examination and electron microscope images confirmed the previous diagnosis of Rosai-Dorfman disease. The clinical and pathological features of this entity are discussed.

scholarly journals Sarcoidosis Presenting as Löfgren’s Syndrome with Myopathy

2013 ◽  
Vol 2013 ◽  
pp. 1-3
Author(s):  
Şenol Kobak ◽  
Murat Yalçin ◽  
Fidan Sever ◽  
Guray Oncel
Keyword(s):  
Enzyme Level ◽  
Lymph Node Biopsy ◽  
Mediastinal Lymphadenopathy ◽  
Movement Restriction ◽  
Muscle Enzymes ◽  
Serum Angiotensin Converting Enzyme ◽  
Angiotensin Converting Enzyme Level ◽  
Node Biopsy ◽  
Thoracic Ct ◽  
Löfgren’S Syndrome

A 34-year-old female patient, who had proximal muscle weakness for 8 months, presented with erythema nodosum lesions on the pretibial region in addition to pain, swelling, and movement restriction in both ankles for the last one month. Thoracic CT demonstrated hilar and mediastinal lymphadenopathy. She underwent mediastinoscopic lymph node biopsy; biopsy result was consistent with noncaseating granuloma. Serum angiotensin converting enzyme level and muscle enzymes have been elevated. Muscular MRI and EMG findings were consistent with myositis. Muscle biopsy was done, and myopathy was found. The patient was diagnosed with sarcoidosis, Löfgren's syndrome, and sarcoid myopathy. The patient displayed remarkable clinical and radiological regression after 6-month corticosteroid and MTX therapy.

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