scholarly journals Sarcoidosis Presenting as Löfgren’s Syndrome with Myopathy

2013 ◽  
Vol 2013 ◽  
pp. 1-3
Author(s):  
Şenol Kobak ◽  
Murat Yalçin ◽  
Fidan Sever ◽  
Guray Oncel
Keyword(s):  
Enzyme Level ◽  
Lymph Node Biopsy ◽  
Mediastinal Lymphadenopathy ◽  
Movement Restriction ◽  
Muscle Enzymes ◽  
Serum Angiotensin Converting Enzyme ◽  
Angiotensin Converting Enzyme Level ◽  
Node Biopsy ◽  
Thoracic Ct ◽  
Löfgren’S Syndrome

A 34-year-old female patient, who had proximal muscle weakness for 8 months, presented with erythema nodosum lesions on the pretibial region in addition to pain, swelling, and movement restriction in both ankles for the last one month. Thoracic CT demonstrated hilar and mediastinal lymphadenopathy. She underwent mediastinoscopic lymph node biopsy; biopsy result was consistent with noncaseating granuloma. Serum angiotensin converting enzyme level and muscle enzymes have been elevated. Muscular MRI and EMG findings were consistent with myositis. Muscle biopsy was done, and myopathy was found. The patient was diagnosed with sarcoidosis, Löfgren's syndrome, and sarcoid myopathy. The patient displayed remarkable clinical and radiological regression after 6-month corticosteroid and MTX therapy.

scholarly journals Coexistence of Ankylosing Spondylitis and Löfgren’s Syndrome

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Senol Kobak ◽  
Fidan Sever ◽  
Oya Sivrikoz ◽  
Ahmet Karaarslan
Keyword(s):  
Ankylosing Spondylitis ◽  
Low Dose ◽  
Histopathological Examination ◽  
Skin Lesions ◽  
Lymph Node Biopsy ◽  
Node Biopsy ◽  
Löfgren’S Syndrome ◽  
Significant Regression ◽  
Dose Corticosteroid ◽  
Thorax Ct

A 46-year-old male patient diagnosed with ankylosing spondylitis presented to our polyclinic with complaints of pain, swelling, and limitation in joint mobility in both ankles and erythema nodosum skin lesions in both pretibial sites. The sacroiliac joint graphy and the MRI taken revealed active and chronic sacroiliitis. On the thorax CT, multiple mediastinal and hilar lymphadenopathies were reported. Mediastinoscopic excisional lymph node biopsy was taken and noncalcified granulomatous structures, lymphocytes, and histiocytes were determined on histopathological examination. The patients were diagnosed with ankylosing spondylitis, sarcoidosis, and Löfgren’s syndrome. NSAIDs, sulfasalazine, and low dose corticosteroid were started. Significant regression was seen in the patient’s subjective and laboratory assessments.

scholarly journals Sarcoid Reactions after Chemotherapy for Hodgkin's Lymphoma

2010 ◽  
Vol 3 ◽  
pp. CCRep.S5243 ◽  
Author(s):  
Baldeep Wirk
Keyword(s):  
Hodgkin’S Lymphoma ◽  
Lymph Node Biopsy ◽  
Hodgkin's Lymphoma ◽  
Mediastinal Lymphadenopathy ◽  
Axillary Lymph ◽  
Chemotherapy Treatment ◽  
Node Biopsy ◽  
Inappropriate Treatment ◽  
Caucasian Female ◽  
New Onset

Introduction There is a reported association between sarcoidosis and malignancy. This is particularly true for lymphomas and is known as the sarcoidosis-lymphoma syndrome. Case report A 49 year old Caucasian female presented with mediastinal and axillary lymphadenopathy. An excisional axillary lymph node biopsy showed classical Hodgkin's lymphoma, nodular sclerosis subtype. She received six cycles of conventional chemotherapy achieving a complete remission with no evidence of any lymphadenopathy on restaging imaging. However, one month after completion of chemotherapy, she developed new onset of progressive mediastinal lymphadenopathy. A mediastinoscopy and biopsy was performed showing noncaseating granulomata and the patient was diagnosed with a sarcoid reaction. Conclusion Sarcoidosis and sarcoid reactions must be considered in the differential diagnosis when assessing patients with persistent or enlargening masses after chemotherapy treatment for Hodgkin's lymphoma, especially since this is associated with a better prognosis. A tissue biopsy is essential prior to starting chemotherapy for presumed relapsed malignancy or persistent disease so as to avoid inappropriate treatment.

scholarly journals “The Great Mimicker”: An Unusual Etiology of Cytopenia, Diffuse Lymphadenopathy, and Massive Splenomegaly

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Mazen Zaarour ◽  
Chanudi Weerasinghe ◽  
Elias Moussaly ◽  
Shafinaz Hussein ◽  
Jean-Paul Atallah
Keyword(s):  
Lymph Node ◽  
Male Patient ◽  
Lymph Node Biopsy ◽  
Mediastinal Lymphadenopathy ◽  
Rare Occurrence ◽  
Massive Splenomegaly ◽  
Multisystem Disease ◽  
Node Biopsy ◽  
Splenic Involvement ◽  
Noncaseating Granulomas

Sarcoidosis is an idiopathic multisystem disease characterized by the formation of noncaseating granulomas. It frequently presents with pulmonary infiltrates and bilateral hilar and mediastinal lymphadenopathy. Splenic involvement is common, but massive splenomegaly is a rare occurrence. Sarcoidosis is known as “the great mimicker” (or “the great imitator”) since it exhibits a myriad of symptoms, mimicking other inflammatory, infectious, and neoplastic conditions, including lymphoma. Herein, we report the case of a 44-year-old male patient who was found to have bicytopenia, hypercalcemia, diffuse lymphadenopathy, and massive splenomegaly, a constellation of findings suggestive of underlying lymphoma. Interestingly, lymph node biopsy showed noncaseating granulomas suggestive of sarcoidosis, without evidence of malignancy.

Elevation of Serum Angiotensin-Converting Enzyme Level

1982 ◽  
Vol 142 (5) ◽  
pp. 893 ◽  
Author(s):  
Stephen A. Borowsky ◽  
Jack Lieberman ◽  
Sandra Strome ◽  
Adriana Sastre
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Enzyme Level ◽  
Converting Enzyme ◽  
Serum Angiotensin Converting Enzyme ◽  
Angiotensin Converting Enzyme Level
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