scholarly journals Larvicidal Activity againstAedes aegyptiand Molluscicidal Activity againstBiomphalaria glabrataof Brazilian Marine Algae

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Elíca Amara Cecília Guedes ◽  
Cenira M. de Carvalho ◽  
Karlos Antonio Lisboa Ribeiro Junior ◽  
Thyago Fernando Lisboa Ribeiro ◽  
Lurdiana Dayse de Barros ◽  
...  
Keyword(s):  
Larvicidal Activity ◽  
Marine Algae ◽  
Biological Activities ◽  
Artemia Salina ◽  
Hypnea Musciformis ◽  
Toxic Compounds ◽  
Padina Gymnospora ◽  
Sargassum Vulgare ◽  
Bioassay Guided Fractionation ◽  
Molluscicidal Activity

This study investigated the biological activities of five benthic marine algae collected from Northeastern Region of Brazil. The tested activities included larvicidal activity againstAedes aegypti, molluscicidal activity againstBiomphalaria glabrata,and toxicity againstArtemia salina. Extracts ofUlva lactuca(Chlorophyta),Padina gymnospora, Sargassum vulgare(Phaeophyta),Hypnea musciformis,andDigenea simplex(Rhodophyta) were prepared using different solvents of increasing polarity, including dichloromethane, methanol, ethanol, and water. Of the extracts screened, the dichloromethane extracts ofH. musciformisandP. gymnosporaexhibited the highest activities and were subjected to bioassay-guided fractionation in hexane and chloroform. The chloroform fractions of theP. gymnosporaandH. musciformisextracts showed molluscicidal activity at values below 40 μg·mL−1(11.1460 μg·mL−1and 25.8689 μg·mL−1, resp.), and the chloroform and hexane fractions ofP. gymnosporashowed larvicidal activity at values below 40 μg·mL−1(29.018 μg·mL−1and 17.230 μg·mL−1, resp.). The crude extracts were not toxic toA. salina, whereas the chloroform and hexane fractions ofP. gymnospora(788.277 μg·mL−1and 706.990 μg·mL−1) showed moderate toxicity, indicating that the toxic compounds present in these algae are nonpolar.

scholarly journals Larvicidal activity, molluscicide and toxicity of the essential oil of Citrus limon peels against, respectively, Aedes aegypti, Biomphalaria glabrata and Artemia salina

2019 ◽  
Vol 44 (4) ◽  
pp. 85 ◽  
Author(s):  
Paulo Roberto Barros Gomes ◽  
Marlucy Bezerra Oliveira ◽  
Dionney Andrade De Sousa ◽  
Jeremias Caetano Da Silva ◽  
Romer Pessôa Fernandes ◽  
...  
Keyword(s):  
Essential Oil ◽  
Aedes Aegypti ◽  
Larvicidal Activity ◽  
Biological Activities ◽  
Biomphalaria Glabrata ◽  
Artemia Salina ◽  
World Health ◽  
Lethal Concentration ◽  
Major Constituent ◽  
Citrus Limon

In this present work, we tested the larvicidal activity, molluscicide and toxicity of the oil extracted from Citrus limon peels, respectively against third stage larvae of Aedes aegypti, snail Biomphalaria glabrata, and Artemia salina. For this, we extract the essential oil by hydrodistillation. Then, we identified and quantified the components by gas chromatography coupled to mass spectrometry (GC-MS). We tested the larvicidal and molluscicidal activity, respectively, using the method adopted by the Brazilian Ministry of Health and the World Health Organization. We calculated the lethal concentration (LC50) from the Probit method for the three biological activities with 95 %. The results of the chromatographic analysis showed that the oil has 58.81% of Limonene (major constituent) and 0.11% α-Mulene (minority component). The essential oil presented lethal concentration (LC50) for larvicidal activity, molluscicide and toxicity, respectively at 15.48, 13.05 and 743.35 mg∙L-1. Therefore, the essential oil is active against larvae of A. aegypti and snail B. glabrata and non-toxic against larvae of A. salina.

Anti-ulcer effects and biological activities of polysaccharides from marine algae

BioFactors ◽  
2000 ◽  
Vol 12 (1-4) ◽  
pp. 267-274 ◽  
Author(s):  
Masato Nagaoka ◽  
Hideyuki Shibata ◽  
Itsuko Kimura-Takagi ◽  
Shusuke Hashimoto ◽  
Ritsuo Aiyama ◽  
...  
Keyword(s):  
Marine Algae ◽  
Biological Activities

scholarly journals Bioassay-guided isolation and identification of Aedes aegypti larvicidal and biting deterrent compounds from Veratrum lobelianum

2018 ◽  
Vol 16 (1) ◽  
pp. 324-332 ◽  
Author(s):  
Nurhayat Tabanca ◽  
Zulfiqar Ali ◽  
Ulrich R. Bernier ◽  
Nancy Epsky ◽  
Ayse Nalbantsoy ◽  
...  
Keyword(s):  
Larvicidal Activity ◽  
Ethanol Extract ◽  
Ethyl Linoleate ◽  
Significant Activity ◽  
Isolation And Identification ◽  
Human Carcinoma ◽  
Ethyl Palmitate ◽  
H Nmr ◽  
Bioassay Guided Fractionation ◽  
Nmr Techniques

AbstractAn ethanol extract fromVeratrum lobelianumBernh. rhizomes showed larvicidal activity with LC50values of 11.79 ppm and 89.9 ppm against 1stand 4thinstar larvae, respectively, at 24 h post-treatment. The extract also showed proportion not biting (PNB) value of 0.76 at 100 μg/cm2against females ofAe.aegypti. Systematic bioassay-guided fractionation ofV.lobelianumextract resulted in the isolation of five compounds that were identified as ethyl palmitate (1), ethyl linoleate (2), β-sitosterol (3), resveratrol (4) and oxyresveratrol (5) by GC-MS,1H-NMR, and13C-NMR techniques, comparison with literature data, and confirmation with authentic compounds. Compound2exhibited larvicidal activity with an LC50value of 24.1 (22.0-26.2) ppm whereas1was inactive. β-Sitosterol (3) displayed the highest larvicidal activity with LC50= 1.7 (1.3-12.3) ppm and LC90= 5.1 (3.4-13.8) ppm. Compounds4and5had larvicidal activity with LC50values of 18.5 (15.3-23.3) and 22.6 (19.0-26.8) ppm, respectively, and had an equivalent PNB values of 0.75 at 25 nmol/cm2. In addition,4and5were explored for their human-based repellency againstAe.aegypti, attractiveness against male medfliesCeratitis capitata, and also evaluated against series of human carcinoma cells (A549, HEK293, HeLa, SH-SY5Y); however, no significant activity was found.

scholarly journals Fucosterol of Marine Macroalgae: Bioactivity, Safety and Toxicity on Organism

Marine Drugs ◽  
2021 ◽  
Vol 19 (10) ◽  
pp. 545
Author(s):  
Maria Dyah Nur Meinita ◽  
Dicky Harwanto ◽  
Gabriel Tirtawijaya ◽  
Bertoka Fajar Surya Perwira Negara ◽  
Jae-Hak Sohn ◽  
...  
Keyword(s):  
Cell Lines ◽  
Marine Algae ◽  
Animal Cell ◽  
Biological Activities ◽  
Clinical Stage ◽  
Bioactive Compound ◽  
Marine Macroalgae ◽  
Pharmaceutical Industries ◽  
Safety And Toxicity ◽  
Meta Analyses

Fucosterol (24-ethylidene cholesterol) is a bioactive compound belonging to the sterol group that can be isolated from marine algae. Fucosterol of marine algae exhibits various biological activities including anti-osteoarthritic, anticancer, anti-inflammatory, anti-photoaging, immunomodulatory, hepatoprotective, anti-neurological, antioxidant, algicidal, anti-obesity, and antimicrobial. Numerous studies on fucosterol, mainly focusing on the quantification and characterization of the chemical structure, bioactivities, and health benefits of fucosterol, have been published. However, there is no comprehensive review on safety and toxicity levels of fucosterol of marine algae. This review aims to discuss the bioactivities, safety, and toxicity of fucosterol comprehensively, which is important for the application and development of fucosterol as a bioactive compound in nutraceutical and pharmaceutical industries. We used four online databases to search for literature on fucosterol published between 2002 and 2020. We identified, screened, selected, and analyzed the literature using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses method and identified 43 studies for review. Despite the potential applications of fucosterol, we identified the need to fill certain related research gaps. Fucosterol exhibited low toxicity in animal cell lines, human cell lines, and animals. However, studies on the safety and toxicity of fucosterol at the clinical stage, which are required before fucosterol is developed for the industry, are lacking.

scholarly journals ERUCA SATIVA, BRASSICACEA, BIOLOGICAL ACTIVITIES EVALUATION

2012 ◽  
Vol 13 (3) ◽  
Author(s):  
Vânia Maria BARBOSA ◽  
Obdulio Gomes MIGUEL ◽  
Cristina M. S. MIYAZAKI ◽  
Maria C. dos Santos VERDAM ◽  
Beatriz C. K. HIROTA ◽  
...  
Keyword(s):  
Biological Activities ◽  
Artemia Salina ◽  
Eruca Sativa

A má alimentação característica dos dias atuais está relacionada com o aumento significativo de doenças crônicas não transmissíveis, sendo a dieta equilibrada, aliada ao consumo de antioxidantes naturais, um objeto para reversão deste quadro. Os metabólitos secundários presentes em vegetais são alternativas de inibidores de radicais livres. Assim, o presente estudo tem como objetivo avaliar a atividade antioxidante de Eruca sativa, a rúcula, utilizando-se o ensaio de redução do radical DPPH e o método de formação do complexo fosfomolibdênio; e avaliar toxicidade frente à Artemia salina e investigar a atividade hemolítica. O extrato etanólico de Eruca sativa apresentou potencial antioxidante no ensaio de redução do complexo do fosfomolibdênio, não mostrou atividade hemolítica e foi considerado ativo na avaliação de toxicidade frente à Artemia salina. Os resultados demonstram a importância de mais testes para avaliação da capacidade antioxidante.

scholarly journals Molluscicidal activity of 2-hydroxy-[1,4]naphthoquinone and derivatives

2008 ◽  
Vol 80 (2) ◽  
pp. 329-334 ◽  
Author(s):  
Celso A. Camara ◽  
Tania M.S. Silva ◽  
Thiago G. da-Silva ◽  
Rodrigo M. Martins ◽  
Ticiano P. Barbosa ◽  
...  
Keyword(s):  
Brine Shrimp ◽  
General Rule ◽  
Biomphalaria Glabrata ◽  
Artemia Salina ◽  
World Health ◽  
Significant Toxicity ◽  
The World ◽  
Health Organization ◽  
Polar Substituents ◽  
Molluscicidal Activity

The toxic profile of lawsone (2-hydroxy-[1,4]naphthoquinone) and a series of [1,4]naphthoquinone derivatives was evaluated against the brine shrimp Artemia salina and against the mollusk Biomphalaria glabrata, the main transmitting vector of schistosomiasis in Brazil. Of the seventeen compounds tested nine fell below the threshold of 100 µg/mL set for potential molluscicidal activity by the World Health Organization. As a general rule derivatives with non-polar substituents presented the highest molluscicidal activities. These substances showed significant toxicity in A. salina lethality bioassay.

Ocean acidification affects biological activities of seaweeds: A case study of Sargassum vulgare from Ischia volcanic CO2 vents

2020 ◽  
Vol 259 ◽  
pp. 113765 ◽  
Author(s):  
Amit Kumar ◽  
Maria Cristina Buia ◽  
Anna Palumbo ◽  
Mohamed Mohany ◽  
Mohammed A.M. Wadaan ◽  
...  
Keyword(s):  
Ocean Acidification ◽  
Biological Activities ◽  
Sargassum Vulgare

scholarly journals Synthesis, Characterization, Antimicrobial, DNA Cleavage, andIn VitroCytotoxic Studies of Some Metal Complexes of Schiff Base Ligand Derived from Thiazole and Quinoline Moiety

2014 ◽  
Vol 2014 ◽  
pp. 1-17 ◽  
Author(s):  
Nagesh Gunvanthrao Yernale ◽  
Mruthyunjayaswamy Bennikallu Hire Mathada
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Dna Cleavage ◽  
Biological Activities ◽  
Artemia Salina ◽  
Spectral Studies ◽  
Antibacterial And Antifungal Activities ◽  
Pyramidal Geometry

A novel Schiff base ligandN-(4-phenylthiazol-2yl)-2-((2-thiaxo-1,2-dihydroquinolin-3-yl)methylene)hydrazinecarboxamide(L)obtained by the condensation ofN-(4-phenylthiazol-2-yl)hydrazinecarboxamide with 2-thioxo-1,2-dihydroquinoline-3-carbaldehyde and its newly synthesized Cu(II), Co(II), Ni(II), and Zn(II) complexes have been characterized by elemental analysis and various spectral studies like FT-IR,1H NMR, ESI mass, UV-Visible, ESR, TGA/DTA, and powder X-ray diffraction studies. The Schiff base ligand(L)behaves as tridentate ONS donor and forms the complexes of type [ML(Cl)2] with square pyramidal geometry. The Schiff base ligand(L)and its metal complexes have been screenedin vitrofor their antibacterial and antifungal activities by minimum inhibitory concentration (MIC) method. The DNA cleavage activity of ligand and its metal complexes were studied using plasmid DNA pBR322 as a target molecule by gel electrophoresis method. The brine shrimp bioassay was also carried out to study thein vitrocytotoxicity properties for the ligand and its metal complexes againstArtemia salina. The results showed that the biological activities of the ligand were found to be increased on complexation.

Naturally occurring and synthetic polyyne glycosides

2009 ◽  
Vol 87 (11) ◽  
pp. 1565-1582 ◽  
Author(s):  
Yanqing Pan ◽  
Todd L. Lowary ◽  
Rik R. Tykwinski
Keyword(s):  
Natural Products ◽  
Marine Algae ◽  
Biological Activities ◽  
Terrestrial Plants ◽  
Natural Sources ◽  
Naturally Occurring

Polyyne glycosides are a class of natural products that have been found in terrestrial plants, fungi, and marine algae. Many display interesting and potentially useful biological activities, which in some cases has initiated synthetic efforts toward their formation. This review provides a comprehensive report of polyyne glycosides isolated from natural sources, as well as the synthesis of these molecules and their analogues.

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