scholarly journals Synthesis, Characterization, Antimicrobial, DNA Cleavage, andIn VitroCytotoxic Studies of Some Metal Complexes of Schiff Base Ligand Derived from Thiazole and Quinoline Moiety

2014 ◽  
Vol 2014 ◽  
pp. 1-17 ◽  
Author(s):  
Nagesh Gunvanthrao Yernale ◽  
Mruthyunjayaswamy Bennikallu Hire Mathada
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Dna Cleavage ◽  
Biological Activities ◽  
Artemia Salina ◽  
Spectral Studies ◽  
Antibacterial And Antifungal Activities ◽  
Pyramidal Geometry

A novel Schiff base ligandN-(4-phenylthiazol-2yl)-2-((2-thiaxo-1,2-dihydroquinolin-3-yl)methylene)hydrazinecarboxamide(L)obtained by the condensation ofN-(4-phenylthiazol-2-yl)hydrazinecarboxamide with 2-thioxo-1,2-dihydroquinoline-3-carbaldehyde and its newly synthesized Cu(II), Co(II), Ni(II), and Zn(II) complexes have been characterized by elemental analysis and various spectral studies like FT-IR,1H NMR, ESI mass, UV-Visible, ESR, TGA/DTA, and powder X-ray diffraction studies. The Schiff base ligand(L)behaves as tridentate ONS donor and forms the complexes of type [ML(Cl)2] with square pyramidal geometry. The Schiff base ligand(L)and its metal complexes have been screenedin vitrofor their antibacterial and antifungal activities by minimum inhibitory concentration (MIC) method. The DNA cleavage activity of ligand and its metal complexes were studied using plasmid DNA pBR322 as a target molecule by gel electrophoresis method. The brine shrimp bioassay was also carried out to study thein vitrocytotoxicity properties for the ligand and its metal complexes againstArtemia salina. The results showed that the biological activities of the ligand were found to be increased on complexation.

scholarly journals Synthesis and Spectral Studies of 4,4′-(Hydrazine-1,2-diylidenedimethylylidene)-bis-(2- methoxyphenol) and Its Transition Metal Complexes with Promising Biological Activities

2020 ◽  
Vol 32 (7) ◽  
pp. 1768-1772
Author(s):  
Anita Rani ◽  
Manoj Kumar ◽  
Hardeep Singh Tuli ◽  
Zahoor Abbas ◽  
Vinit Prakash
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Schiff Base Ligand ◽  
Biological Activities ◽  
Condensation Reaction ◽  
Analytical Techniques ◽  
Spectral Studies

The study describes the synthesis, characterization and biological activity of a novel Schiff base ligand and its transition metal complexes. The Schiff base ligand was obtained by a condensation reaction between 4-hydroxy-3-methoxybenzaldehyde (p-vanillin) and hydrazine hydrate using ethanol as solvent. A new series of Ni(II) and Fe(III) complexes were also derived by reaction of prepared Schiff base ligand with NiCl2 and FeCl3. Both the ligand and its metal complexes were characterized by solubility, melting point and elemental analysis. These compounds were further identified by analytical techniques, FTIR, NMR and mass spectrometry. The ligand and its transition metal complexes were also subjected to in vitro biological activities i.e. antimicrobial, antiangiogenic and DNA photo cleavage. For antimicrobial activity compounds were tested against two strains of bacteria and two strains of fungi. Different concentrations of prepared compounds were treated with fertilized chicken eggs and plasmid DNA to find out antiangiogenic and DNA photocleavage activity, respectively.

Synthesis, spectral characterization and some biological studies of transition metal complexes with Schiff base ligand containing N,O and S as donor atoms

2017 ◽  
Vol 13 (9) ◽  
pp. 6513-6519
Author(s):  
Anil Kumar M R ◽  
Shanmukhappa S ◽  
Rangaswamy B E ◽  
Revanasiddappa M
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Schiff Base Ligand ◽  
Dna Cleavage ◽  
Schiff Base Complexes ◽  
Spectral Studies ◽  
Planar Geometry ◽  
Biological Studies

Transition metal complexes of Cu(II), Co(II), Ni(II), Zn(II), Cd(II) and Mn(II) have been synthesized with the Schiff base ligand 5-Sub-N-(2-mercaptophenyl)salicylideneimine. Elemental analysis of these complexes suggest that these metal ions forms complexes of type ML(H2O)stoichiometry for Cu(II), Co(II), Ni(II), Zn(II), Cd(II) and Mn(II). The ligand behaves as tridentate and forms coordinate bonds through O, S and N atoms. Magnetic susceptibility, IR, UV – Visible, Mass and ESR spectral studies suggest that Cu(II), Ni(II) complexes posses square planar geometry, whereas Co(II), Zn(II), Cd(II) and Mn(II) complexes posses tetrahedral geometry. The complexes were tested for their antimicrobial activity against the bacterial strains Staphylococcus aureus and Bacillus subtilis.The Schiff base metal complexes evaluated for their antifungal activity against the fungi A. niger and C. oxysporum. The DNA cleavage studies of Schiff base complexes werestudied using Calf – Thymus DNA by agarose gel electrophoresis method.

scholarly journals Novel Cr(III), Co(II), Zn(II) and Cd(II) Complexes of Schiff Base Ligand Derived from Salicyaldehyde and 3,4-Diaminotoluene: Synthesis, Characterization and Biological Screening

2020 ◽  
Vol 32 (5) ◽  
pp. 1091-1096
Author(s):  
Netra Pal Singh ◽  
Uma Agarwal ◽  
Anuroop Kumar ◽  
Kaushal Kumar
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Conductivity Measurement ◽  
Chelating Agent ◽  
Molar Ratio ◽  
Spectral Studies ◽  
Tetrahedral Geometry ◽  
Antibacterial And Antifungal

A new Schiff base ligand (L) [2,2′-((1Z,1′Z)-((4-methyl-1,2- phenylene)bis(azanylidene))bis(methanylylidene))diphenol], derived from condensation of salicyaldehyde and 3,4-diamino toluene. The synthesized ligand was used for complexation with different metal ions Cr(III), Co(II), Zn(II) and Cd(II) using a molar ratio of metal:ligand (1:1). The synthesized ligand and its metal complexes were characterized by TLC, NMR (1H & 13C), UV-visible, mass, FT-IR spectroscopies, elemental analysis, magnetic moment and conductivity measurement. On the basis of above studies the proposed structure of synthesized mononuclear metal complexes have been found to possess tetrahedral geometry while Cr(III) and Co(II) ions possess octahedral geometry. The spectral studies revealed that the synthesized ligand was acting as tetradentate chelating agent and coordinated to metal centre via deprotonated phenolate oxygen and azomethine-N atom. The biological activity of ligand and its metal complexes were screened in vitro against Gram-negative bacteria (Salmonella typhimurium and E. coli), Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) and fungus (Aspergillus fumigatus) to ascertain their antibacterial and antifungal properties.

scholarly journals Synthesis and Spectral Investigations of Polymeric Hydrazone Schiff Base and its Transition Metal Complexes with Promising Antimicrobial, Anti-Angeogenic and DNA Photo-Cleavage Activities

2019 ◽  
Vol 31 (10) ◽  
pp. 2331-2336 ◽  
Author(s):  
Manoj Kumar ◽  
Anita Rani ◽  
Hardeep Singh Tuli ◽  
Rajshree Khare ◽  
Vinit Parkash
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Schiff Base Ligand ◽  
Biological Activities ◽  
Free Ligand ◽  
Ft Ir ◽  
Bacteria And Fungi

This report describes the synthesis and exploration of novel Schiff base ligand in the form of a polymer (heptamer) which was prepared by reaction between 3,4-diacetyl-2,5-hexanedione and hydrazine hydrate in ethanol. On further reaction of Schiff base with transition metals ions (Co and Cu) leads to formation of its transition metal complexes. The structural identification of Schiff base ligand and its transition metal complexes were characterized by classical structural techniques like FT-IR, NMR and mass spectra. The free ligand and its transition metal complexes have been screened for in vitro biological activities against various strains of bacteria and fungi. The prepared Schiff base and its metal complexes were also screened for antiangiogenic activity. The results have shown the remarkable antimicrobial and antiangiogenic activities of the Schiff base and its metal complexes.

scholarly journals Synthesis, Characterization, and Biological Activity of Some Transition Metal Complexes Derived from Novel Hydrazone Azo Schiff Base Ligand

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
C. Anitha ◽  
S. Sumathi ◽  
P. Tharmaraj ◽  
C. D. Sheela
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Second Harmonic ◽  
Biological Activities ◽  
Diffusion Method ◽  
Spectral Studies ◽  
Planar Geometry ◽  
Conductivity Measurements ◽  
Tetrahedral Geometry

A series of metal(II) complexes ML where M = VO(II), Co(II), Ni(II), Cu(II), and Zn(II) have been synthesized from azo Schiff base ligand (N′E)-N′-(5-((4-chlorophenyl)diazenyl)-2-hydroxybenzylidene)-2-hydroxybenzohydrazide and characterized on the basis of elemental analyses, electronic, IR, and 1H NMR spectra, magnetic susceptibility and also by aid of scanning electron microscopy (SEM), X-ray powder diffraction, fluorescence spectral studies, and molar conductivity measurements. Conductivity measurements reveal that the complexes are nonelectrolytes. Spectroscopy and other analytical studies reveal distorted square planar geometry for copper, square-pyramidal geometry for oxovanadium, and tetrahedral geometry for other complexes. Redox behavior of the copper(II) complex has been studied with cyclic voltammetry, and the biological activities of the ligand and metal complexes have been studied against several microorganisms by the well diffusion method. All synthesized compounds can serve as potential photoactive materials as indicated from their characteristic fluorescence properties. The second harmonic generation (SHG) efficiency of the ligand was measured and found to be higher than that of urea and KDP. The SEM image of the copper(II) complex implies that the size of the particles is 50 nm.

scholarly journals Synthesis, Characterization and Biological Activity of ONO Donor Schiff Base and its Metal Complexes

2022 ◽  
Vol 34 (2) ◽  
pp. 389-394
Author(s):  
R. Nalini ◽  
S.M. Basavarajaiah ◽  
N.G. Yernale ◽  
K. Ramakrishna Reddy
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Biological Activity ◽  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Artemia Salina ◽  
Antimicrobial Action ◽  
Donor Ligand ◽  
Spectral Techniques

A new Schiff base ligand (E)-2-((7-hydroxy-4-methyl-2-oxo-2H-chromen-8-yl)methylene)-N-(5- methyl-3-phenyl-1H-indol-2-yl)hydrazine carboxamide (L) (3) was synthesized by the reaction of N-(5-methyl-3-phenyl-1H-indol-2-yl)hydrazinecarboxamide (1) and 7-hydroxy-4-methyl-2-oxo-2Hchromene- 8-carbaldehyde (2). The Cu(II), Co(II), Ni(II) and Zn(II) metal complexes (4a-d) were synthesized and its structural elucidation was done by different spectral techniques. The Schiff base (3) behaves as ONO donor ligand and forms the complexes of the sort [M(L)(Cl)(H2O)2] for Cu(II) (4a) and Zn(II) (4d) and [M(L)2] for Co(II) (4b) and Ni(II) (4c). Compounds (3) and (4a-d) were tested in vitro for antimicrobial action, cytotoxicity property against Artemia salina and anti-tuberculosis assay against Mycobacterium tuberculosis (ATCC 25177). The metal complexes showed very good biological activity.

DNA cleavage mechanism by metal complexes of Cu(II), Zn(II) and VO(IV) with a schiff-base ligand

Biochimie ◽  
2021 ◽  
Vol 186 ◽  
pp. 43-50
Author(s):  
María R. Rodríguez ◽  
Martín J. Lavecchia ◽  
Beatriz S. Parajón-Costa ◽  
Ana C. González-Baró ◽  
María R. González-Baró ◽  
...  
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Dna Cleavage

scholarly journals Synthesis, Characterization, Antimicrobial and Anticancer Activity of New Bidentate Schiff Base Ligand and their Transition Metal(II) Complexes

2021 ◽  
Vol 33 (7) ◽  
pp. 1488-1494
Author(s):  
S. Arulmozhi ◽  
G. Sasikumar ◽  
A. Subramani ◽  
A. Sudha ◽  
S.J. Askar Ali
Keyword(s):  
Schiff Base ◽  
Anticancer Activity ◽  
Cell Lines ◽  
Schiff Base Ligand ◽  
Pathogenic Bacteria ◽  
Human Tumor ◽  
Spectral Studies ◽  
Breast Adenocarcinoma ◽  
Human Colon Cancer

The metal(II) complexes were synthesized by addition of corresponding MCl2 (M = Mn2+, Ni2+, Cu2+ and Zn2+) with 1,2-bis(1H-pyrrol-2-ylmethylene)diazane in methanol. The ligand acts as a bidentate as confirmed from the mass, IR, UV, NMR and EPR spectral studies. The Schiff base ligand forms hexa-coordinated complexes having octahedral geometry for Mn(II), Ni(II), Zn(II) and Cu(II) complexes. The metal complexes showed an excellent antimicrobial activity spectrum in vitro against both Gram-negative (Klebsiella pneumoniae and Acinetobacter baumannii), Gram-positive (Staphylococcus aureus and Enterococcus faecalis) and human pathogenic bacteria isolates. To find the binding affinity with protein BSA kinase, for that molecular docking studies were also carried for all the four synthesized metal(II) complexes. The anticancer activity of the synthesized metal(II) complexes was also screened against the three human tumor cell lines MCF7 human breast adenocarcinoma cell line, CaSki human caucasian cervical epidermoid carcinoma and HCT116 human colon cancer cell lines. The present study showed that Zn(II) complex showed potent inhibition by the ratio of 80% as compared to the inhibition in the normal cells (L-6).

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